Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway
Upon ligand binding, RTK autophosphorylates (phosphates are shown as red circles) on tyrosine residues, which serve as docking sites for adaptor and signalling molecules. Ras and Rap1 are activated by the recruitment of guanosine-nucleotide exchange factors (SOS, C3G) via adaptor proteins (Shc and Grb2; Crk). Ras can activate Raf-1 and B-Raf; Rap1 presumably can activate B-Raf. Raf proteins phosphorylate and activate MEK-1/2, which in turn activate ERK-1/2 (indicated by black arrows). Negative-feedback loops (indicated by red lines) include the induction of MKPs by ERK as well as the inhibitory phosphorylation of Raf-1 and SOS.
Publication
Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway. (2005) Richard J. Orton, et al. Biochem J. 2005 Dec 1;392(Pt 2):249-261. Figure: F3.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Drosophila melanogaster | Invertebrates | Rap-GAP | RAPGAP | ncbigene_synonym | RapGAP1 | 34032 |
| Drosophila melanogaster | Invertebrates | Ras-GAP | RAS-GAP | ncbigene_synonym | vap | 32569 |
| Drosophila melanogaster | Invertebrates | Ras-GAP | RAS-GAP | ncbigene_synonym | RasGAP1 | 39158 |
| Drosophila melanogaster | Invertebrates | Shc | SHC | ncbigene_symbol | Shc | 44052 |
| Drosophila melanogaster | Invertebrates | Grb2 | GRB2 | ncbigene_synonym | drk | 36497 |
| Drosophila melanogaster | Invertebrates | sos | SOS | ncbigene_symbol | Sos | 34790 |
| Drosophila melanogaster | Invertebrates | Crk | CRK | ncbigene_symbol | Crk | 43775 |
| Drosophila melanogaster | Invertebrates | Crk | CRK | ncbigene_synonym | NA | 32026 |
| Drosophila melanogaster | Invertebrates | C3G | C3G | ncbigene_symbol | C3G | 31618 |
| Drosophila melanogaster | Invertebrates | C3G | C3G | ncbigene_synonym | c(3)G | 47765 |
| Drosophila melanogaster | Invertebrates | Rap1 | RAP1 | ncbigene_symbol | Rap1 | 38244 |
| Drosophila melanogaster | Invertebrates | Ras | RAS | ncbigene_symbol | ras | 43873 |
| Drosophila melanogaster | Invertebrates | Ras | RAS | ncbigene_synonym | Ras64B | 38494 |
| Drosophila melanogaster | Invertebrates | Ras | RAS | ncbigene_synonym | Ras85D | 41140 |
| Drosophila melanogaster | Invertebrates | Raf-1 | RAF-1 | ncbigene_synonym | Raf | 31221 |
| Drosophila melanogaster | Invertebrates | ERK-1/2 | ERK2 | ncbigene_synonym | p38a | 42866 |
| Drosophila melanogaster | Invertebrates | ERK-1/2 | ERK1 | ncbigene_synonym | rl | 3354888 |
| Drosophila melanogaster | Invertebrates | RTK | RTK | ncbigene_synonym | Tie | 38559 |
| Drosophila melanogaster | Invertebrates | RTK | RTK | ncbigene_synonym | InR | 42549 |
| Homo sapiens | Primates | Rap-GAP | RAPGAP | ncbigene_synonym | RAP1GAP | 5909 |
| Homo sapiens | Primates | Ras-GAP | RASGAP | ncbigene_synonym | RASA1 | 5921 |
| Homo sapiens | Primates | Shc | SHC | ncbigene_synonym | SHC1 | 6464 |
| Homo sapiens | Primates | Shc | SHC | famplex_relations | SHC2 | 25759 |
| Homo sapiens | Primates | Shc | SHC | famplex_relations | SHC3 | 53358 |
| Homo sapiens | Primates | Shc | SHC | famplex_relations | SHC4 | 399694 |
| Homo sapiens | Primates | Grb2 | GRB2 | ncbigene_symbol | GRB2 | 2885 |
| Homo sapiens | Primates | sos | SOS | ncbigene_synonym | XYLT2 | 64132 |
| Homo sapiens | Primates | sos | SOS | famplex_relations | SOS1 | 6654 |
| Homo sapiens | Primates | sos | SOS | famplex_relations | SOS2 | 6655 |
| Homo sapiens | Primates | Crk | CRK | ncbigene_symbol | CRK | 1398 |
| Homo sapiens | Primates | C3G | C3G | ncbigene_synonym | RAPGEF1 | 2889 |
| Homo sapiens | Primates | Rap1 | RAP1 | ncbigene_synonym | RAP1A | 5906 |
| Homo sapiens | Primates | Rap1 | RAP1 | ncbigene_synonym | RABGEF1 | 27342 |
| Homo sapiens | Primates | Rap1 | RAP1 | ncbigene_synonym | TERF2IP | 54386 |
| Homo sapiens | Primates | Rap1 | RAP1 | famplex_relations | RAP1B | 5908 |
| Homo sapiens | Primates | Ras | RAS | famplex_relations | KRAS | 3845 |
| Homo sapiens | Primates | Ras | RAS | famplex_relations | HRAS | 3265 |
| Homo sapiens | Primates | Ras | RAS | famplex_relations | NRAS | 4893 |
| Homo sapiens | Primates | Raf-1 | RAF-1 | ncbigene_synonym | RAF1 | 5894 |
| Homo sapiens | Primates | B-Raf | B-RAF | ncbigene_synonym | BRAF | 673 |
| Homo sapiens | Primates | MEK-1/2 | MEK1 | ncbigene_synonym | MAP2K1 | 5604 |
| Homo sapiens | Primates | MEK-1/2 | MEK2 | ncbigene_synonym | MAP2K2 | 5605 |
| Homo sapiens | Primates | ERK-1/2 | ERK-2 | ncbigene_synonym | MAPK1 | 5594 |
| Homo sapiens | Primates | ERK-1/2 | ERK-1 | ncbigene_synonym | MAPK3 | 5595 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|---|---|---|---|
| Cancer | NA | |||
| Noonan syndrome | NA |