Knockdown of Smad4 affects only a subset of TGF-Beta-regulated target genes and functions

Knockdown of Smad4 affects only a subset of TGF-β-regulated target genes and functions. Knockdown of Smad4 in HaCaT cells and in Colo-357 cells reveals that the TGF-β signaling pathway has a Smad4-dependent component and a Smad4-independent component. TGF-β-induced functions that we have shown to be Smad4 dependent or Smad4 independent are shown. Examples of genes that may be involved in these functions, based on the literature, are indicated.
Knockdown of Smad4 affects only a subset of TGF-Beta-regulated target genes and functions
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Publication

Smad4 Dependency Defines Two Classes of Transforming Growth Factor β (TGF-β) Target Genes and Distinguishes TGF-β-Induced Epithelial-Mesenchymal Transition from Its Antiproliferative and Migratory Responses . (2005) Laurence Levy, et al. Mol Cell Biol. 2005 Sep;25(18):8108-8125. Figure: F7.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates TGF-B-induced TGFB ncbigene_synonym TGFB1 7040
Homo sapiens Primates TGF-B-induced TGFB famplex_relations TGFB2 7042
Homo sapiens Primates TGF-B-induced TGFB famplex_relations TGFB3 7043
Homo sapiens Primates still STI1L ncbigene_synonym STIP1 10963
Homo sapiens Primates Smad4 SMAD4 ncbigene_symbol SMAD4 4089
Homo sapiens Primates JUNB JUNB ncbigene_symbol JUNB 3726
Homo sapiens Primates JUNB JUNB ncbigene_synonym RNASEH2A 10535
Homo sapiens Primates TCF8 TCF8 ncbigene_synonym ZEB1 6935
Homo sapiens Primates Runx1 RUNX1 ncbigene_symbol RUNX1 861
Homo sapiens Primates ELK3 ELK3 ncbigene_symbol ELK3 2004
Homo sapiens Primates ELK3 ELK3 ncbigene_synonym KCNH8 131096
Homo sapiens Primates HES1 HES1 ncbigene_symbol HES1 3280
Homo sapiens Primates HES1 HES1 ncbigene_synonym GATD3 8209
Homo sapiens Primates SNAI2 SNAI2 ncbigene_symbol SNAI2 6591
Homo sapiens Primates (Sno) SNO ncbigene_synonym SKIL 6498
Homo sapiens Primates (Sno) SNO ncbigene_synonym SBNO2 22904
Homo sapiens Primates (Sno) SNO ncbigene_synonym SBNO1 55206
Homo sapiens Primates sox4 SOX4 ncbigene_symbol SOX4 6659
Homo sapiens Primates GATA3 GATA3 ncbigene_symbol GATA3 2625
Homo sapiens Primates CITED2 CITED2 ncbigene_symbol CITED2 10370
Homo sapiens Primates a1 A1 ncbigene_synonym ADRA1D 146
Homo sapiens Primates EMT EMT ncbigene_synonym ITK 3702
Homo sapiens Primates EMT EMT ncbigene_synonym SLC22A3 6581
Homo sapiens Primates NET1 NET1 ncbigene_symbol NET1 10276
Homo sapiens Primates NET1 NET1 ncbigene_synonym SLC6A2 6530
Homo sapiens Primates NET1 NET1 ncbigene_synonym SLC6A5 9152
Homo sapiens Primates NET1 NET1 ncbigene_synonym NTN1 9423
Homo sapiens Primates NET1 NET1 ncbigene_synonym TSPAN1 10103
Homo sapiens Primates NET1 NET1 ncbigene_synonym PRPF38B 55119
Homo sapiens Primates actin ACTIN famplex_relations ACTA1 58
Homo sapiens Primates actin ACTIN famplex_relations ACTA2 59
Homo sapiens Primates actin ACTIN famplex_relations ACTB 60
Homo sapiens Primates actin ACTIN famplex_relations ACTC1 70
Homo sapiens Primates actin ACTIN famplex_relations ACTG1 71
Homo sapiens Primates actin ACTIN famplex_relations ACTG2 72
Homo sapiens Primates p114-Rho-GEF P114RHOGEF ncbigene_synonym ARHGEF18 23370
Homo sapiens Primates ADAM19 ADAM19 ncbigene_symbol ADAM19 8728
Homo sapiens Primates CLAUDIN1 CLAUDIN1 ncbigene_synonym CLDN7 1366
Homo sapiens Primates (p21) P21 ncbigene_synonym CDKN1A 1026
Homo sapiens Primates (p21) P21 ncbigene_synonym TCEAL1 9338
Homo sapiens Primates (p21) P21 ncbigene_synonym NSG1 27065
Homo sapiens Primates (p21) P21 ncbigene_synonym H3P16 644914
Homo sapiens Primates CDKN1A CDKN1A ncbigene_synonym CDPF1 150383
Homo sapiens Primates AKAP12 AKAP12 ncbigene_symbol AKAP12 9590
Homo sapiens Primates GADD45B GADD45B ncbigene_symbol GADD45B 4616
Homo sapiens Primates PAI-1 PAI-1 ncbigene_synonym SERPINE1 5054
Homo sapiens Primates ITGB6 ITGB6 ncbigene_symbol ITGB6 3694
Homo sapiens Primates SMURF1 SMURF1 ncbigene_symbol SMURF1 57154
Homo sapiens Primates DLX2 DLX2 ncbigene_symbol DLX2 1746
Homo sapiens Primates HEF1 HEF1 ncbigene_synonym NEDD9 4739
Homo sapiens Primates PAR6 PAR6 ncbigene_synonym PARD6A 50855
Homo sapiens Primates PAR6 PAR6 ncbigene_synonym PWAR6 100506965
Danio rerio Vertebrates Smad4 SMAD4 ncbigene_synonym smad4a 559111
Danio rerio Vertebrates Smad4 SMAD4 ncbigene_synonym smad4b 794669
Danio rerio Vertebrates JUNB JUNB ncbigene_synonym junba 407086
Danio rerio Vertebrates Runx1 RUNX1 ncbigene_symbol runx1 58126
Danio rerio Vertebrates ELK3 ELK3 ncbigene_symbol elk3 557074
Danio rerio Vertebrates SNAI2 SNAI2 ncbigene_symbol snai2 494038
Danio rerio Vertebrates sox4 SOX4 ncbigene_synonym sox4a 336346
Danio rerio Vertebrates GATA3 GATA3 ncbigene_symbol gata3 30458
Danio rerio Vertebrates CITED2 CITED2 ncbigene_symbol cited2 450024
Danio rerio Vertebrates NET1 NET1 ncbigene_symbol net1 493607
Danio rerio Vertebrates NET1 NET1 ncbigene_synonym ntn1b 30192
Danio rerio Vertebrates ADAM19 ADAM19 ncbigene_synonym adam19b 571252
Danio rerio Vertebrates (p21) P21 ncbigene_synonym cdkn1a 100151416
Danio rerio Vertebrates AKAP12 AKAP12 ncbigene_synonym akap12b 567365
Danio rerio Vertebrates GADD45B GADD45B ncbigene_synonym gadd45ba 406304
Danio rerio Vertebrates PAI-1 PAI-1 ncbigene_synonym serpine1 100136840
Danio rerio Vertebrates ITGB6 ITGB6 ncbigene_symbol itgb6 100499533
Danio rerio Vertebrates SMURF1 SMURF1 ncbigene_symbol smurf1 321695
Danio rerio Vertebrates DLX2 DLX2 ncbigene_synonym dlx2a 30574

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID