Signaling pathways in osteogenesis and osteoclastogenesis

Signaling pathways in osteogenesis and osteoclastogenesis. Osteoblasts produce RANKL that is either neutralized by circulating OPG or triggers a signaling cascade involving TRAF6 and MAPK which activates transcription factors (NFATc1 and NF-κB) for bone resorption. SMAD-dependent BMP signaling involves a complex containing Smad4 which translocate into the nucleus to trigger osteogenesis. SMAD4 also binds to FZD promoter and activates Wnt signaling pathways [64]. Binding of Wnt ligand to frizzled (FZD) receptors initiates Wnt β-catenin signaling pathway. Ligand binding activates adenylate cyclase (AC) that convert ATP to cAMP which ultimately binds to protein kinase A (PKA) to phosphorylate cAMP response element binding protein (CREB) at Ser133 site to control gene expression
Signaling pathways in osteogenesis and osteoclastogenesis
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Publication

Emerging Roles of Natural Compounds in Osteoporosis: Regulation, Molecular Mechanisms and Bone Regeneration (2024) Sidra Ilyas, et al. Pharmaceuticals (Basel). 2024 Aug;17(8). Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates OPG OPG ncbigene_synonym BTF3P11 690
Homo sapiens Primates OPG OPG ncbigene_synonym TNFRSF11B 4982
Homo sapiens Primates CTS CTS ncbigene_synonym TTR 7276
Homo sapiens Primates CTSK CTSK ncbigene_symbol CTSK 1513
Homo sapiens Primates IKK IKK famplex_relations CHUK 1147
Homo sapiens Primates IKK IKK famplex_relations IKBKB 3551
Homo sapiens Primates IKK IKK famplex_relations IKBKG 8517
Homo sapiens Primates IKK IKK famplex_relations IKBKE 9641
Homo sapiens Primates IKK IKK famplex_relations TBK1 29110
Homo sapiens Primates NF-kB NF-KB ncbigene_synonym NFKB1 4790
Homo sapiens Primates NFATc1 NFATC1 ncbigene_symbol NFATC1 4772
Homo sapiens Primates TRAP TRAP ncbigene_symbol TRAP 100187907
Homo sapiens Primates TRAP TRAP ncbigene_synonym ACP5 54
Homo sapiens Primates TRAP TRAP ncbigene_synonym CD40LG 959
Homo sapiens Primates TRAP TRAP ncbigene_synonym TRAF2 7186
Homo sapiens Primates TRAP TRAP ncbigene_synonym TRRAP 8295
Homo sapiens Primates TRAP TRAP ncbigene_synonym TDRD7 23424
Homo sapiens Primates TRAP TRAP ncbigene_synonym SCYL1 57410
Homo sapiens Primates TRAF2 TRAF2 ncbigene_synonym TANK 10010
Homo sapiens Primates TRAF2/6 TRAF6 ncbigene_symbol TRAF6 7189
Homo sapiens Primates MKK3/6 MKK6 ncbigene_synonym MAP2K6 5608
Homo sapiens Primates MKK3/6 MKK3 ncbigene_synonym MAP2K3 5606
Homo sapiens Primates p38 P38 ncbigene_synonym CRK 1398
Homo sapiens Primates p38 P38 ncbigene_synonym MAPK14 1432
Homo sapiens Primates p38 P38 ncbigene_synonym MAPK1 5594
Homo sapiens Primates p38 P38 ncbigene_synonym AIMP2 7965
Homo sapiens Primates p38 P38 ncbigene_synonym GRAP2 9402
Homo sapiens Primates p38 P38 ncbigene_synonym AHSA1 10598
Homo sapiens Primates p38 P38 ncbigene_synonym POLDIP2 26073
Homo sapiens Primates p38 P38 famplex_relations MAPK11 5600
Homo sapiens Primates p38 P38 famplex_relations MAPK12 6300
Homo sapiens Primates p38 P38 famplex_relations MAPK13 5603
Homo sapiens Primates RANKL RANKL ncbigene_synonym TNFSF11 8600
Homo sapiens Primates RANK RANK ncbigene_synonym TNFRSF11A 8792
Homo sapiens Primates RAS RAS famplex_relations KRAS 3845
Homo sapiens Primates RAS RAS famplex_relations HRAS 3265
Homo sapiens Primates RAS RAS famplex_relations NRAS 4893
Homo sapiens Primates MEK1/2 MEK2 ncbigene_synonym MAP2K2 5605
Homo sapiens Primates MEK1/2 MEK1 ncbigene_synonym MAP2K1 5604
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates Runx2 RUNX2 ncbigene_symbol RUNX2 860
Homo sapiens Primates BMP2 BMP2 ncbigene_symbol BMP2 650
Homo sapiens Primates WNT WNT famplex_relations WNT1 7471
Homo sapiens Primates WNT WNT famplex_relations WNT2 7472
Homo sapiens Primates WNT WNT famplex_relations WNT2B 7482
Homo sapiens Primates WNT WNT famplex_relations WNT3 7473
Homo sapiens Primates WNT WNT famplex_relations WNT3A 89780
Homo sapiens Primates WNT WNT famplex_relations WNT4 54361
Homo sapiens Primates WNT WNT famplex_relations WNT6 7475
Homo sapiens Primates WNT WNT famplex_relations WNT7A 7476
Homo sapiens Primates WNT WNT famplex_relations WNT7B 7477
Homo sapiens Primates WNT WNT famplex_relations WNT8A 7478
Homo sapiens Primates WNT WNT famplex_relations WNT8B 7479
Homo sapiens Primates WNT WNT famplex_relations WNT9A 7483
Homo sapiens Primates WNT WNT famplex_relations WNT9B 7484
Homo sapiens Primates WNT WNT famplex_relations WNT10A 80326
Homo sapiens Primates WNT WNT famplex_relations WNT10B 7480
Homo sapiens Primates WNT WNT famplex_relations WNT11 7481
Homo sapiens Primates WNT WNT famplex_relations WNT16 51384
Homo sapiens Primates WNT WNT famplex_relations WNT5A 7474
Homo sapiens Primates WNT WNT famplex_relations WNT5B 81029
Homo sapiens Primates FZD FZD famplex_relations FZD1 8321
Homo sapiens Primates FZD FZD famplex_relations FZD10 11211
Homo sapiens Primates FZD FZD famplex_relations FZD2 2535
Homo sapiens Primates FZD FZD famplex_relations FZD3 7976
Homo sapiens Primates FZD FZD famplex_relations FZD4 8322
Homo sapiens Primates FZD FZD famplex_relations FZD5 7855
Homo sapiens Primates FZD FZD famplex_relations FZD6 8323
Homo sapiens Primates FZD FZD famplex_relations FZD7 8324
Homo sapiens Primates FZD FZD famplex_relations FZD8 8325
Homo sapiens Primates FZD FZD famplex_relations FZD9 8326
Homo sapiens Primates RAF RAF ncbigene_synonym ZHX2 22882
Homo sapiens Primates RAF RAF famplex_relations ARAF 369
Homo sapiens Primates RAF RAF famplex_relations BRAF 673
Homo sapiens Primates RAF RAF famplex_relations RAF1 5894
Homo sapiens Primates MKK4 MKK4 ncbigene_synonym MAP2K4 6416
Homo sapiens Primates MKK4/7 MKK7 ncbigene_synonym MAP2K7 5609
Homo sapiens Primates SMAD1 SMAD1 ncbigene_symbol SMAD1 4086
Homo sapiens Primates SMAD1 SMAD1 ncbigene_synonym GARS1 2617
Homo sapiens Primates SMAD1/5/8 SMAD8 ncbigene_synonym SMAD9 4093
Homo sapiens Primates SMAD1/5/8 SMAD5 ncbigene_symbol SMAD5 4090
Homo sapiens Primates SMAD4 SMAD4 ncbigene_symbol SMAD4 4089
Homo sapiens Primates SMAD SMAD famplex_relations SMAD6 4091
Homo sapiens Primates SMAD SMAD famplex_relations SMAD7 4092
Homo sapiens Primates SMAD SMAD famplex_relations SMAD2 4087
Homo sapiens Primates SMAD SMAD famplex_relations SMAD3 4088
Homo sapiens Primates B-CATENIN CTNNB1 ncbigene_symbol CTNNB1 1499
Homo sapiens Primates TCF/LEF TCF ncbigene_synonym HNF4A 3172
Homo sapiens Primates MCSF MCSF ncbigene_synonym CSF1 1435
Homo sapiens Primates CFMS CFMS ncbigene_synonym CSF1R 1436
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates CREB CREB ncbigene_synonym CREB1 1385
Homo sapiens Primates CREB CREB famplex_relations CREB3 10488
Homo sapiens Primates CREB CREB famplex_relations CREB5 9586
Homo sapiens Primates CREB CREB famplex_relations CREB3L1 90993
Homo sapiens Primates CREB CREB famplex_relations CREB3L2 64764
Homo sapiens Primates CREB CREB famplex_relations CREB3L3 84699
Homo sapiens Primates CREB CREB famplex_relations CREB3L4 148327
Homo sapiens Primates CREB CREB famplex_relations CREM 1390
Homo sapiens Primates CREB CREB famplex_relations ATF1 466
Homo sapiens Primates CREB CREB famplex_relations ATF2 1386
Homo sapiens Primates AC ADCY famplex_relations ADCY1 107
Homo sapiens Primates AC ADCY famplex_relations ADCY2 108
Homo sapiens Primates AC ADCY famplex_relations ADCY3 109
Homo sapiens Primates AC ADCY famplex_relations ADCY4 196883
Homo sapiens Primates AC ADCY famplex_relations ADCY5 111
Homo sapiens Primates AC ADCY famplex_relations ADCY6 112
Homo sapiens Primates AC ADCY famplex_relations ADCY7 113
Homo sapiens Primates AC ADCY famplex_relations ADCY8 114
Homo sapiens Primates AC ADCY famplex_relations ADCY9 115
Homo sapiens Primates AC ADCY famplex_relations ADCY10 55811
Homo sapiens Primates PKA PKA famplex_relations PRKAR1A 5573
Homo sapiens Primates PKA PKA famplex_relations PRKAR1B 5575
Homo sapiens Primates PKA PKA famplex_relations PRKAR2A 5576
Homo sapiens Primates PKA PKA famplex_relations PRKAR2B 5577
Homo sapiens Primates PKA PKA famplex_relations PRKACA 5566
Homo sapiens Primates PKA PKA famplex_relations PRKACB 5567
Homo sapiens Primates PKA PKA famplex_relations PRKACG 5568

Chemical mentions

Word Match MeSH Name ChEBI
OPG OPG chebi:63300
RAS RAS (1R)-N-(prop-2-yn-1-yl)indan-1-amine chebi:63620
CAMP cAMP adenosine 3',5'-(hydrogen phosphate) chebi:17489
Nucleus nucleus nucleus chebi:33252

Disease mentions

Word Match MeSH Name DOID