Three main UPR pathways induced by ER stress
The three main UPR pathways induced by ER stress. Molecules and pathways involved in UPR, and their relation to IR signaling. Arrow (blue, orange and green): activation, Blue color arrow: PERK pathway, Orange color pathway: IRE-1 pathway, Green color arrow: ATF6 pathway
Publication
Molecular Aspects in the Development of Type 2 Diabetes and Possible Preventive and Complementary Therapies (2024) Laura Simon-Szabó, et al. Int J Mol Sci. 2024 Aug;25(16). Figure: F3.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Caenorhabditis elegans | Invertebrates | elF2a | EIF2A | ncbigene_symbol | eif-2alpha | 171769 |
| Caenorhabditis elegans | Invertebrates | elF2a | EIF2A | ncbigene_symbol | eif-2A | 174606 |
| Caenorhabditis elegans | Invertebrates | ATF4 | ATF4 | ncbigene_symbol | atf-4 | 181576 |
| Caenorhabditis elegans | Invertebrates | ATF6 | ATF6 | ncbigene_symbol | atf-6 | 181405 |
| Caenorhabditis elegans | Invertebrates | IRE-1 | IRE-1 | ncbigene_symbol | ire-1 | 174305 |
| Homo sapiens | Primates | IRS-1 | IRS1 | ncbigene_symbol | IRS1 | 3667 |
| Homo sapiens | Primates | PERK | PERK | ncbigene_synonym | EIF2AK3 | 9451 |
| Homo sapiens | Primates | elF2a | EIF2A | ncbigene_symbol | EIF2A | 83939 |
| Homo sapiens | Primates | elF2a | EIF2A | ncbigene_synonym | EIF2S1 | 1965 |
| Homo sapiens | Primates | ATF4 | ATF4 | ncbigene_symbol | ATF4 | 468 |
| Homo sapiens | Primates | JNK | JNK | ncbigene_synonym | MAPK8 | 5599 |
| Homo sapiens | Primates | JNK | JNK | famplex_relations | MAPK9 | 5601 |
| Homo sapiens | Primates | JNK | JNK | famplex_relations | MAPK10 | 5602 |
| Homo sapiens | Primates | Bip | BIP | ncbigene_synonym | GDF10 | 2662 |
| Homo sapiens | Primates | Bip | BIP | ncbigene_synonym | HSPA5 | 3309 |
| Homo sapiens | Primates | PDI | PDI | ncbigene_synonym | P4HB | 5034 |
| Homo sapiens | Primates | PDI | PDI | ncbigene_synonym | PADI1 | 29943 |
| Homo sapiens | Primates | PDI | PDI | ncbigene_synonym | PDIA2 | 64714 |
| Homo sapiens | Primates | ATF6 | ATF6 | ncbigene_symbol | ATF6 | 22926 |
| Homo sapiens | Primates | IRE-1 | IRE1 | ncbigene_synonym | ERN1 | 2081 |
| Homo sapiens | Primates | c-Jun | C-JUN | ncbigene_synonym | JUN | 3725 |
| Homo sapiens | Primates | CHOP | CHOP | ncbigene_synonym | DDIT3 | 1649 |
| Homo sapiens | Primates | Trb3 | TRB3 | ncbigene_synonym | TAS2R13 | 50838 |
| Homo sapiens | Primates | Trb3 | TRB3 | ncbigene_synonym | TRIB3 | 57761 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| PERK | PERK | tetrachloroethene | chebi:17300 | |
| Nucleus | nucleus | nucleus | chebi:33252 | |
| ROS | ROS | chebi:26523 | ||
| CHOP | ChoP | N,N,N-trimethyl-2-(phosphonooxy)ethanaminium | chebi:18132 | |
| CHOP | ChoP | N,N,N-trimethyl-2-(phosphonooxy)ethanaminium | chebi:18132 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|