Probiotic targetingTLR2/TLR4 /NFKB signaling pathway to prevent inflammatory changes and mastitis

Mechanism of probiotic targetingTLR2/TLR4 /NF-κB signaling pathway to prevent inflammatory changes and mastitis. Probiotics inhibit IKK, thereby preventing phosphorylation of IκBα. Furthermore, IκBα super-repressor specifically prevent NF-κB subunits p65 and p50 and other members from entering the nucleus
Probiotic targetingTLR2/TLR4 /NFKB signaling pathway to prevent inflammatory changes and mastitis
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Publication

Bioactive Compounds and Probiotics Mitigate Mastitis by Targeting NF-κB Signaling Pathway (2024) Muhammad Zahoor Khan, et al. Biomolecules. 2024 Aug;14(8). Figure: F3.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates IKKY IKKG ncbigene_synonym IKBKG 8517
Homo sapiens Primates IKKA IKKA ncbigene_synonym CHUK 1147
Homo sapiens Primates IKKẞ IKK famplex_relations IKBKB 3551
Homo sapiens Primates IKKẞ IKK famplex_relations IKBKE 9641
Homo sapiens Primates IKKẞ IKK famplex_relations TBK1 29110
Homo sapiens Primates TLR2 TLR2 ncbigene_symbol TLR2 7097
Homo sapiens Primates TLR4 TLR4 ncbigene_symbol TLR4 7099
Homo sapiens Primates MyD88 MYD88 ncbigene_symbol MYD88 4615
Homo sapiens Primates IRAK1 IRAK1 ncbigene_symbol IRAK1 3654
Homo sapiens Primates IRAK1/4 IRAK4 ncbigene_symbol IRAK4 51135
Homo sapiens Primates TRAF2 TRAF2 ncbigene_symbol TRAF2 7186
Homo sapiens Primates TRAF2 TRAF2 ncbigene_synonym TANK 10010
Homo sapiens Primates BRIC2 BRIC2 ncbigene_synonym ABCB11 8647
Homo sapiens Primates TRAF3 TRAF3 ncbigene_symbol TRAF3 7187
Homo sapiens Primates TRAF6 TRAF6 ncbigene_symbol TRAF6 7189
Homo sapiens Primates NIK NIK ncbigene_synonym MAP3K14 9020
Homo sapiens Primates NIK NIK ncbigene_synonym MAP4K4 9448
Homo sapiens Primates P50 P50 ncbigene_synonym CD40 958
Homo sapiens Primates P50 P50 ncbigene_synonym ARHGEF7 8874
Homo sapiens Primates P50 P50 ncbigene_synonym ASCC1 51008
Homo sapiens Primates P50 P50 ncbigene_synonym H3P40 115482723
Homo sapiens Primates p65 P65 ncbigene_synonym RELA 5970
Homo sapiens Primates p65 P65 ncbigene_synonym SYT1 6857
Homo sapiens Primates p65 P65 ncbigene_synonym GORASP1 64689
Homo sapiens Primates p65 P65 ncbigene_synonym WNK1 65125
Homo sapiens Primates p100 P100 ncbigene_synonym CUX1 1523
Homo sapiens Primates p100 P100 ncbigene_synonym NFKB2 4791
Homo sapiens Primates p100 P100 ncbigene_synonym OAS3 4940
Homo sapiens Primates p100 P100 ncbigene_synonym PMEL 6490
Homo sapiens Primates p100 P100 ncbigene_synonym SART3 9733
Homo sapiens Primates p100 P100 ncbigene_synonym TPX2 22974
Homo sapiens Primates p100 P100 ncbigene_synonym SND1 27044
Homo sapiens Primates p100 P100 ncbigene_synonym ASCC2 84164

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID