HER2/epidermal growth factor receptor (EGFR) signalling pathway in breast cancer

HER2/epidermal growth factor receptor (EGFR) signalling pathway in breast cancer. The HER2/EGFR signalling pathway in breast cancer involves the activation of HER2 and EGFR, which are tyrosine kinase receptors. When these receptors are overexpressed or mutated, they dimerise and activate downstream signalling cascades, including the PI3K/AKT and MAPK pathways. This leads to increased cell proliferation, survival, and metastasis. HER2-positive breast cancers are particularly aggressive but can be targeted with therapies like trastuzumab and pertuzumab, which block HER2 signalling
HER2/epidermal growth factor receptor (EGFR) signalling pathway in breast cancer
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Publication

Advancements in Understanding the Hide-and-Seek Strategy of Hibernating Breast Cancer Cells and Their Implications in Oncology from a Broader Perspective: A Comprehensive Overview (2024) Aiman Al-Ruwishan, et al. Curr Issues Mol Biol. 2024 Aug;46(8). Figure: F7.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates SMAD2 SMAD2 ncbigene_symbol SMAD2 4087
Homo sapiens Primates HER2 HER2 ncbigene_synonym ERBB2 2064
Homo sapiens Primates EGFR EGFR ncbigene_symbol EGFR 1956
Homo sapiens Primates TGFB TGFB ncbigene_synonym TGFB1 7040
Homo sapiens Primates TGFB TGFB famplex_relations TGFB2 7042
Homo sapiens Primates TGFB TGFB famplex_relations TGFB3 7043
Homo sapiens Primates SMAD3 SMAD3 ncbigene_symbol SMAD3 4088
Homo sapiens Primates SMAD4 SMAD4 ncbigene_symbol SMAD4 4089
Homo sapiens Primates РІЗК/АКТ KAT ncbigene_synonym KATNB1 10300
Homo sapiens Primates РІЗК/АКТ KAT ncbigene_synonym F11R 50848
Homo sapiens Primates РІЗК/АКТ KAT ncbigene_synonym TSTD1 100131187
Homo sapiens Primates EMT, EMT ncbigene_synonym ITK 3702
Homo sapiens Primates EMT, EMT ncbigene_synonym SLC22A3 6581

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID