Sphingolipid metabolism

Schematic representation of sphingolipid metabolism. The pleotropic properties of sphingolipids play a pivotal role in hematopoiesis, migration of lymphocytes, immune response, and the signaling pathway for progression of B cell malignancies. SPT, serine palmitoyl transferase; CerS, dihydroceramide synthase; DES, dihydroceramide desaturase; SPHK, Sphingosine kinase; CerK, ceramide kinase; C1PP, ceramide-1-phosphate phosphatase; GCase, gluco-cylceramidase; GCS, glucosylceramide synthase; SMS, sphingomyelinase synthase; SMase, sphingomyelinase
Sphingolipid metabolism
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Publication

Leveraging altered lipid metabolism in treating B cell malignancies (2024) Jaewoong Lee, et al. Prog Lipid Res. 2024 Jul 17;95(NA). Figure: F4.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates SPT SPT ncbigene_synonym AGXT 189
Homo sapiens Primates DES DES ncbigene_symbol DES 1674
Homo sapiens Primates SMS SMS ncbigene_symbol SMS 6611
Homo sapiens Primates SMS SMS ncbigene_synonym RAI1 10743
Homo sapiens Primates Cerk CERK ncbigene_symbol CERK 64781
Homo sapiens Primates GCS GCS ncbigene_synonym GCLC 2729
Homo sapiens Primates GCS GCS ncbigene_synonym UGCG 7357
Homo sapiens Primates SPHK SPHK ncbigene_synonym SPHK1 8877
Homo sapiens Primates SPHK SPHK famplex_relations SPHK2 56848

Chemical mentions

Word Match MeSH Name ChEBI
Glucosylceramide glucosylceramide chebi:195532
Sphinganine sphinganine (2S,3R)-1,3-dihydroxyoctadecan-2-aminium chebi:57817
Dihydroceramide Dihydroceramide an N-acylsphinganine chebi:31488
DES DES 4,4'-(3E)-hex-3-ene-3,4-diyldiphenol chebi:41922
Sphingomyelin Sphingomyelin chebi:89491
Ceramide ceramide an N-acylsphing-4-enine chebi:52639
Sphingosine SPHINGOSINE (2R,3S,4Z)-2-aminooctadec-4-ene-1,3-diol chebi:45719
Sphingosine-1-phosphate sphingosine-1-phosphate (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate chebi:37550

Disease mentions

Word Match MeSH Name DOID