Tamoxifen resistance

Mechanism of tamoxifen resistance. The activation of the E2/ERα signaling pathway contributes to tamoxifen sensitivity. By contrast, the activation of the PI3K/AKT/mTOR signaling pathway leads to tamoxifen resistance. E2, oestrogen; ERα, estrogen receptor α; PIP2, phosphatidylinositol 4,5-bisphosphate; PIP3, phosphatidylinositol 3,4,5-trisphosphate; IRS, insulin receptor substrate; PTEN, phosphatase and tensin homolog; PDK1, 3-phosphoinositide-dependent protein kinase 1; TSC, tuberous sclerosis complex; mTORC1, target of rapamycin complex 1; 4E-BP1, eukaryotic translation initiation factor 4E binding protein; S6K, p70/85 S6 kinase; PPARγ, peroxisome proliferator-activated receptor gamma; Elf4e, eukaryotic initiation factor 4E
Tamoxifen resistance
Download JPG
View figure at PMC Read paper at PMC
PMC

Publication

Crosstalk of methylation and tamoxifen in breast cancer (Review) (2024) Jin Shen, et al. Mol Med Rep. 2024 Oct;30(4). Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates E2/ERA ERA ncbigene_synonym ESR1 2099
Homo sapiens Primates E2/ERA ERA ncbigene_synonym ERAL1 26284
Homo sapiens Primates mTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates PI3K/AKT/mTOR AKT ncbigene_synonym AKT1 207
Homo sapiens Primates PI3K/AKT/mTOR AKT famplex_relations AKT2 208
Homo sapiens Primates PI3K/AKT/mTOR AKT famplex_relations AKT3 10000
Homo sapiens Primates IRS IRS ncbigene_synonym IARS1 3376
Homo sapiens Primates IRS IRS famplex_relations IRS1 3667
Homo sapiens Primates IRS IRS famplex_relations IRS2 8660
Homo sapiens Primates IRS IRS famplex_relations IRS4 8471
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates PDK1 PDK1 ncbigene_symbol PDK1 5163
Homo sapiens Primates PDK1 PDK1 ncbigene_synonym PDPK1 5170
Homo sapiens Primates ERK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates ERK ERK ncbigene_synonym MAPK1 5594
Homo sapiens Primates ERK ERK famplex_relations MAPK3 5595
Homo sapiens Primates KRAS KRAS ncbigene_symbol KRAS 3845
Homo sapiens Primates KRAS KRAS ncbigene_synonym NRAS 4893
Homo sapiens Primates TSC1/2 TSC1 ncbigene_symbol TSC1 7248
Homo sapiens Primates TSC1/2 TSC1 ncbigene_synonym CCL26 10344
Homo sapiens Primates TSC1/2 TSC2 ncbigene_symbol TSC2 7249
Homo sapiens Primates Rheb RHEB ncbigene_symbol RHEB 6009
Homo sapiens Primates Rheb RHEB ncbigene_synonym RHEBP1 6008
Homo sapiens Primates Raf RAF ncbigene_synonym ZHX2 22882
Homo sapiens Primates Raf RAF famplex_relations ARAF 369
Homo sapiens Primates Raf RAF famplex_relations BRAF 673
Homo sapiens Primates Raf RAF famplex_relations RAF1 5894
Homo sapiens Primates MEK MEK ncbigene_synonym MAP2K7 5609
Homo sapiens Primates MEK MEK famplex_relations MAP2K1 5604
Homo sapiens Primates MEK MEK famplex_relations MAP2K2 5605
Homo sapiens Primates mTORC1 MTORC1 famplex_relations RPTOR 57521
Homo sapiens Primates 4E-BP1 4E-BP1 ncbigene_synonym EIF4EBP1 1978
Homo sapiens Primates S6K S6K ncbigene_synonym RPS6KB1 6198
Homo sapiens Primates SREBP1/2 SREBP1 ncbigene_synonym SREBF1 6720
Homo sapiens Primates SREBP1/2 SREBP2 ncbigene_synonym SREBF2 6721

Chemical mentions

Word Match MeSH Name ChEBI
ERa ERA chebi:51451
Tamoxifen tamoxifen 2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine chebi:41774
MEK MEK butan-2-one chebi:28398

Disease mentions

Word Match MeSH Name DOID