The PI3K/Akt/mTOR Axis in Head and Neck Squamous Cell Carcinoma
The PAM signaling pathway composition and function
Publication
The Role of the PI3K/Akt/mTOR Axis in Head and Neck Squamous Cell Carcinoma (2024) Qian Jiang, et al. Biomedicines. 2024 Jul;12(7). Figure: F1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | GPCRs | GPCR | ncbigene_synonym | FZD4 | 8322 |
| Homo sapiens | Primates | GPCRs | GPCR | ncbigene_synonym | NMUR1 | 10316 |
| Homo sapiens | Primates | GPCRs | GPCR | ncbigene_synonym | LPAR3 | 23566 |
| Homo sapiens | Primates | GPCRs | GPCR | ncbigene_synonym | LGR6 | 59352 |
| Homo sapiens | Primates | GPCRs | GPCR | ncbigene_synonym | MRGPRX3 | 117195 |
| Homo sapiens | Primates | GPCRs | GPCR | ncbigene_synonym | MRGPRX4 | 117196 |
| Homo sapiens | Primates | GPCRs | GPCR | ncbigene_synonym | GPR151 | 134391 |
| Homo sapiens | Primates | GPCRs | GPCR | ncbigene_synonym | OXER1 | 165140 |
| Homo sapiens | Primates | GPCRs | GPCR | ncbigene_synonym | GPRC6A | 222545 |
| Homo sapiens | Primates | GPCRs | GPCR | ncbigene_synonym | MRGPRX1 | 259249 |
| Homo sapiens | Primates | GPCRs | GPCR | ncbigene_synonym | VN1R17P | 441931 |
| Homo sapiens | Primates | GPCRs | GPCR | ncbigene_synonym | GPR166P | 442206 |
| Homo sapiens | Primates | GPCRs | GPCR | famplex_relations | GRM1 | 2911 |
| Homo sapiens | Primates | GPCRs | GPCR | famplex_relations | GRM2 | 2912 |
| Homo sapiens | Primates | GPCRs | GPCR | famplex_relations | GRM3 | 2913 |
| Homo sapiens | Primates | GPCRs | GPCR | famplex_relations | GRM4 | 2914 |
| Homo sapiens | Primates | GPCRs | GPCR | famplex_relations | GRM5 | 2915 |
| Homo sapiens | Primates | GPCRs | GPCR | famplex_relations | GRM6 | 2916 |
| Homo sapiens | Primates | GPCRs | GPCR | famplex_relations | GRM7 | 2917 |
| Homo sapiens | Primates | GPCRs | GPCR | famplex_relations | GRM8 | 2918 |
| Homo sapiens | Primates | GPCRs | GPCR | famplex_relations | CASR | 846 |
| Homo sapiens | Primates | GPCRs | GPCR | famplex_relations | GABBR1 | 2550 |
| Homo sapiens | Primates | GPCRs | GPCR | famplex_relations | GABBR2 | 9568 |
| Homo sapiens | Primates | GPCRs | GPCR | famplex_relations | GPR156 | 165829 |
| Homo sapiens | Primates | GPCRs | GPCR | famplex_relations | GPR158 | 57512 |
| Homo sapiens | Primates | GPCRs | GPCR | famplex_relations | GPR179 | 440435 |
| Homo sapiens | Primates | GPCRs | GPCR | famplex_relations | GPRC5A | 9052 |
| Homo sapiens | Primates | GPCRs | GPCR | famplex_relations | GPRC5B | 51704 |
| Homo sapiens | Primates | GPCRs | GPCR | famplex_relations | GPRC5C | 55890 |
| Homo sapiens | Primates | GPCRs | GPCR | famplex_relations | GPRC5D | 55507 |
| Homo sapiens | Primates | p85 | P85 | ncbigene_synonym | PIK3R1 | 5295 |
| Homo sapiens | Primates | p85 | P85 | ncbigene_synonym | PIK3R2 | 5296 |
| Homo sapiens | Primates | p85 | P85 | ncbigene_synonym | ARHGEF7 | 8874 |
| Homo sapiens | Primates | p85 | P85 | ncbigene_synonym | CBFA2T2 | 9139 |
| Homo sapiens | Primates | p85 | P85 | ncbigene_synonym | PPP1R13B | 23368 |
| Homo sapiens | Primates | p85 | P85 | ncbigene_synonym | PPP1R12C | 54776 |
| Homo sapiens | Primates | p110a | P110A | ncbigene_synonym | PIK3CA | 5290 |
| Homo sapiens | Primates | p87 | P87 | ncbigene_synonym | IMMT | 10989 |
| Homo sapiens | Primates | p87/p101 | P101 | ncbigene_synonym | PIK3R5 | 23533 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CB | 5291 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CD | 5293 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CG | 5294 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R3 | 8503 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R4 | 30849 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R6 | 146850 |
| Homo sapiens | Primates | HIF1a | HIF1A | ncbigene_symbol | HIF1A | 3091 |
| Homo sapiens | Primates | PTEN | PTEN | ncbigene_symbol | PTEN | 5728 |
| Homo sapiens | Primates | AKT | AKT | ncbigene_synonym | AKT1 | 207 |
| Homo sapiens | Primates | AKT | AKT | famplex_relations | AKT2 | 208 |
| Homo sapiens | Primates | AKT | AKT | famplex_relations | AKT3 | 10000 |
| Homo sapiens | Primates | TSC1 | TSC1 | ncbigene_symbol | TSC1 | 7248 |
| Homo sapiens | Primates | TSC1 | TSC1 | ncbigene_synonym | CCL26 | 10344 |
| Homo sapiens | Primates | TSC2 | TSC2 | ncbigene_symbol | TSC2 | 7249 |
| Homo sapiens | Primates | mLST8 | MLST8 | ncbigene_symbol | MLST8 | 64223 |
| Homo sapiens | Primates | mTOR | MTOR | ncbigene_symbol | MTOR | 2475 |
| Homo sapiens | Primates | PRAS40 | PRAS40 | ncbigene_synonym | AKT1S1 | 84335 |
| Homo sapiens | Primates | DEPTOR | DEPTOR | ncbigene_symbol | DEPTOR | 64798 |
| Homo sapiens | Primates | Mdm2 | MDM2 | ncbigene_symbol | MDM2 | 4193 |
| Homo sapiens | Primates | mTORC1 | MTORC1 | famplex_relations | RPTOR | 57521 |
| Homo sapiens | Primates | p53 | P53 | ncbigene_synonym | TP53 | 7157 |
| Homo sapiens | Primates | p53 | P53 | famplex_relations | TP63 | 8626 |
| Homo sapiens | Primates | p53 | P53 | famplex_relations | TP73 | 7161 |
| Homo sapiens | Primates | 4E-BP1 | 4E-BP1 | ncbigene_synonym | EIF4EBP1 | 1978 |
| Homo sapiens | Primates | VEGF | VEGF | ncbigene_synonym | VEGFA | 7422 |
| Homo sapiens | Primates | VEGF | VEGF | famplex_relations | VEGFB | 7423 |
| Homo sapiens | Primates | VEGF | VEGF | famplex_relations | VEGFC | 7424 |
| Homo sapiens | Primates | VEGF | VEGF | famplex_relations | VEGFD | 2277 |
| Homo sapiens | Primates | VEGF | VEGF | famplex_relations | PGF | 5228 |
| Homo sapiens | Primates | p70S6K | P70S6K | ncbigene_synonym | RPS6KB1 | 6198 |
| Homo sapiens | Primates | p70S6K | P70S6K | famplex_relations | RPS6KB2 | 6199 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| raptor | Raptor | rac-ammonium 5-(methoxymethyl)-2-[4-methyl-5-oxo-4-(propan-2-yl)-4,5-dihydro-1H-imidazol-2-yl]pyridine-3-carboxylate | chebi:133232 | |
| protein | Protein | a protein | chebi:16541 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|