Coagulation, fibrinolysis, and angiogenesis in cancer

Overview of coagulation, fibrinolysis, and angiogenesis in cancer. The activation of platelets leads to their swelling and the release of angiogenic factors. These affect the vascular endothelia of healing and tumour tissues. The blue arrows facilitate angiogenesis and the red arrows are inhibitory (ATIII=antithrombin III, F1 + 2=prothrombin fragments, PAI=plasminogen activator inhibitor, PDGF=platelet derived growth factor, PF4=platelet factor 4, TF=tissue factor, TFPI=tissue factor pathway inhibitor, TSP1/2=thrombospondin 1 and 2, tPA=tissue type plasminogen activator, uPA=urokinase type plasminogen activator, VEGF=vascular endothelial growth factor)
Coagulation, fibrinolysis, and angiogenesis in cancer
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Publication

Antithrombotic therapy in special circumstances. I—pregnancy and cancer. (2003) Bernd Jilma, et al. BMJ. 2003 Jan 4;326(7379):37-40. Figure: F4.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates TF TF ncbigene_symbol TF 7018
Homo sapiens Primates Fibrinogen FIBRINOGEN famplex_relations FGA 2243
Homo sapiens Primates Fibrinogen FIBRINOGEN famplex_relations FGB 2244
Homo sapiens Primates Fibrinogen FIBRINOGEN famplex_relations FGG 2266
Homo sapiens Primates TFPI TFPI ncbigene_symbol TFPI 7035
Homo sapiens Primates Plasmin PLG ncbigene_symbol PLG 5340
Homo sapiens Primates PAI PAI ncbigene_synonym SERPINE1 5054
Homo sapiens Primates PAI PAI ncbigene_synonym SERPINB2 5055
Homo sapiens Primates VEGF VEGF ncbigene_synonym VEGFA 7422
Homo sapiens Primates VEGF VEGF famplex_relations VEGFB 7423
Homo sapiens Primates VEGF VEGF famplex_relations VEGFC 7424
Homo sapiens Primates VEGF VEGF famplex_relations VEGFD 2277
Homo sapiens Primates VEGF VEGF famplex_relations PGF 5228
Homo sapiens Primates TSP1 TSP1 ncbigene_synonym THBS1 7057
Homo sapiens Primates TSP1 TSP1 ncbigene_synonym CRISP2 7180
Homo sapiens Primates TSP1 TSP1 ncbigene_synonym PRSS55 203074
Homo sapiens Primates TSP1/2 TSP2 ncbigene_synonym THBS2 7058
Homo sapiens Primates uPA UPA ncbigene_synonym PLAU 5328
Homo sapiens Primates uPA UPA ncbigene_synonym PRAP1 118471
Homo sapiens Primates PDGF PDGF famplex_relations PDGFA 5154
Homo sapiens Primates PDGF PDGF famplex_relations PDGFB 5155
Homo sapiens Primates PDGF PDGF famplex_relations PDGFC 56034
Homo sapiens Primates PDGF PDGF famplex_relations PDGFD 80310
Homo sapiens Primates tPA TPA ncbigene_synonym HADHA 3030
Homo sapiens Primates tPA TPA ncbigene_synonym PLAT 5327
Homo sapiens Primates F1+2 F12 ncbigene_symbol F12 2161
Homo sapiens Primates PF4 PF4 ncbigene_symbol PF4 5196

Chemical mentions

Word Match MeSH Name ChEBI
Angiostatin NA mesh:D043168

Disease mentions

Word Match MeSH Name DOID