Schematic diagram showing the NAD+ metabolic pathway
Schematic diagram showing the NAD+ metabolic pathway. NPT, nicotinic acid phosphoribosyltransferase; NMNAT, nicotinamide mononucleotide adenylyl transferase; NRK, nicotinamide riboside kinase; 5′-NT, 5′-nucleotidase; iNampt, intracellular NAM phosphoribosyl transferase; SIRT1, Sirtuin1; CYP2E1, cytochrome P450 2E1; NNMT, nicotinamide N-methyltransferase; AOX, aldehyde oxidase; NANM, nicotinic acid mononucleotide; NAR, nicotinic acid riboside; NAM, nicotinamide; NMN, nicotinamide mononucleotide; NR, nicotinamide riboside; NAD, nicotinamide adenine dinucleotide; NNO, NAM N-oxide; MNA, N1-methylniacinamide; 2PY, N1-methyl-2-pyridone-5-carboxamide; 4PY, N1-methyl-4-pyridone-3-carboxamide; PARP1, poly ADP-ribose polymerase 1
Publication
Nmnat1 Deficiency Causes Mitoribosome Excess in Diabetic Nephropathy Mediated by Transcriptional Repressor HIC1 (2024) Kazuhiro Hasegawa, et al. Int J Mol Sci. 2024 Jun;25(12). Figure: F1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | NMRK1,2 | NMRK2 | ncbigene_symbol | NMRK2 | 27231 |
| Homo sapiens | Primates | NMRK1,2 | NMRK1 | ncbigene_symbol | NMRK1 | 54981 |
| Homo sapiens | Primates | NAM | NAM | ncbigene_synonym | STAC3 | 246329 |
| Homo sapiens | Primates | CYP2E1 | CYP2E1 | ncbigene_symbol | CYP2E1 | 1571 |
| Homo sapiens | Primates | NAR | NAR | ncbigene_synonym | CPSF4 | 10898 |
| Homo sapiens | Primates | NAMPT | NAMPT | ncbigene_symbol | NAMPT | 10135 |
| Homo sapiens | Primates | NNMT | NNMT | ncbigene_symbol | NNMT | 4837 |
| Homo sapiens | Primates | NMNAT | NMNAT | ncbigene_synonym | NMNAT1 | 64802 |
| Homo sapiens | Primates | SIRT1 | SIRT1 | ncbigene_symbol | SIRT1 | 23411 |
| Homo sapiens | Primates | Aox | AOX | ncbigene_synonym | ACOX1 | 51 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| Nicotinic Acid | nicotinic acid | pyridine-3-carboxylic acid | chebi:15940 | |
| Tryptophan | tryptophan | (2S)-2-azaniumyl-3-(1H-indol-3-yl)propanoate | chebi:57912 | |
| NAMPT | Nampt | chebi:195368 | ||
| NMN | NMN | 3-carbamoyl-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridinium | chebi:16171 | |
| N-oxide | N-oxide | chebi:35580 | ||
| NNO | Nno | nonanoyl | chebi:25580 | |
| Deamido-NAD | Deamido-NAD | adenosine 5'-{3-[1-(3-carboxypyridinio)-1,4-anhydro-D-ribitol-5-yl] dihydrogen diphosphate} | chebi:18304 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
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