Action of Isoflavone Derived from Soy-Based Tempeh as an Antioxidant and Breast Cancer Inhibitor via Potential Upregulation of miR-7-5p: A Multimodal Analysis Integrating Pharmacoinformatics and Cellular Studies
Biomechanism of SBT-P and derived isoflavones in breast cancer pathway modulation
Publication
Mechanism of Action of Isoflavone Derived from Soy-Based Tempeh as an Antioxidant and Breast Cancer Inhibitor via Potential Upregulation of miR-7-5p: A Multimodal Analysis Integrating Pharmacoinformatics and Cellular Studies (2024) Fahrul Nurkolis, et al. Antioxidants (Basel). 2024 Jun;13(6). Figure: F6.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | PARP1 | PARP1 | ncbigene_symbol | PARP1 | 142 |
| Homo sapiens | Primates | HER2 | HER2 | ncbigene_synonym | ERBB2 | 2064 |
| Homo sapiens | Primates | EGFR | EGFR | ncbigene_symbol | EGFR | 1956 |
| Homo sapiens | Primates | IGF1R | IGF1R | ncbigene_symbol | IGF1R | 3480 |
| Homo sapiens | Primates | ABCC1 | ABCC1 | ncbigene_symbol | ABCC1 | 4363 |
| Homo sapiens | Primates | CDK1 | CDK1 | ncbigene_symbol | CDK1 | 983 |
| Homo sapiens | Primates | ROS1 | ROS1 | ncbigene_symbol | ROS1 | 6098 |
| Homo sapiens | Primates | Bax | BAX | ncbigene_symbol | BAX | 581 |
| Homo sapiens | Primates | Smad4) | SMAD4 | ncbigene_symbol | SMAD4 | 4089 |
| Homo sapiens | Primates | Smad2 | SMAD2 | ncbigene_symbol | SMAD2 | 4087 |
| Homo sapiens | Primates | Smad3 | SMAD3 | ncbigene_symbol | SMAD3 | 4088 |
| Homo sapiens | Primates | JAK | JAK | famplex_relations | JAK1 | 3716 |
| Homo sapiens | Primates | JAK | JAK | famplex_relations | JAK2 | 3717 |
| Homo sapiens | Primates | JAK | JAK | famplex_relations | JAK3 | 3718 |
| Homo sapiens | Primates | JAK | JAK | famplex_relations | TYK2 | 7297 |
| Homo sapiens | Primates | mTOR | MTOR | ncbigene_symbol | MTOR | 2475 |
| Homo sapiens | Primates | STAT3 | STAT3 | ncbigene_symbol | STAT3 | 6774 |
| Homo sapiens | Primates | TGF-B1 | TGF-B1 | ncbigene_synonym | TGFB1 | 7040 |
| Homo sapiens | Primates | AKT/PI3K | PI3K | ncbigene_synonym | PIK3CA | 5290 |
| Homo sapiens | Primates | AKT/PI3K | PI3K | ncbigene_synonym | PIK3CB | 5291 |
| Homo sapiens | Primates | AKT/PI3K | PI3K | ncbigene_synonym | PIK3CD | 5293 |
| Homo sapiens | Primates | AKT/PI3K | PI3K | ncbigene_synonym | PIK3CG | 5294 |
| Homo sapiens | Primates | AKT/PI3K | PI3K | famplex_relations | PIK3R3 | 8503 |
| Homo sapiens | Primates | AKT/PI3K | PI3K | famplex_relations | PIK3R4 | 30849 |
| Homo sapiens | Primates | AKT/PI3K | PI3K | famplex_relations | PIK3R5 | 23533 |
| Homo sapiens | Primates | AKT/PI3K | PI3K | famplex_relations | PIK3R6 | 146850 |
| Homo sapiens | Primates | AKT/PI3K | PI3K | famplex_relations | PIK3R1 | 5295 |
| Homo sapiens | Primates | AKT/PI3K | PI3K | famplex_relations | PIK3R2 | 5296 |
| Homo sapiens | Primates | AKT/PI3K | AKT | ncbigene_synonym | AKT1 | 207 |
| Homo sapiens | Primates | AKT/PI3K | AKT | famplex_relations | AKT2 | 208 |
| Homo sapiens | Primates | AKT/PI3K | AKT | famplex_relations | AKT3 | 10000 |
| Homo sapiens | Primates | PTEN | PTEN | ncbigene_symbol | PTEN | 5728 |
| Homo sapiens | Primates | iNOS | INOS | ncbigene_synonym | NOS2 | 4843 |
| Homo sapiens | Primates | iNOS | INOS | ncbigene_synonym | ISYNA1 | 51477 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| Isoflavones | isoflavones | an isoflavone | chebi:38757 | |
| inhibitor | inhibitor | inhibitor | chebi:35222 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|---|---|---|---|
| Cancer | cancer | cancer | DOID:162 |