Oxytocin signaling brain pathway

Oxytocin signaling brain pathway. The signaling pathway for the comparison, EAE/CBD asymptomatic vs. EAE/CBD symptomatic, was generated from IPA. Oxytocin was significantly increased (red) in CBD-treated asymptomatic mice, which is predicted to lead to downstream decreases (green) in tumor necrosis factor (TNF), interleukin-1B (IL1B), inflammasome, and PI3K. CO, corn oil (vehicle)
Oxytocin signaling brain pathway
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Publication

Oxytocin and Vasopressin Gene Expression in the Brain as Potential Biomarkers for Cannabidiol Therapeutic Efficacy (2024) Christa M. Frodella, et al. Biomedicines. 2024 Jun;12(6). Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates OXT OXT ncbigene_symbol OXT 5020
Homo sapiens Primates SLC12A5 SLC12A5 ncbigene_symbol SLC12A5 57468
Homo sapiens Primates peri- PERI ncbigene_synonym PLIN1 5346
Homo sapiens Primates TRPV1 TRPV1 ncbigene_symbol TRPV1 7442
Homo sapiens Primates EGFR EGFR ncbigene_symbol EGFR 1956
Homo sapiens Primates Gprotein GPROTEIN famplex_relations GNAO1 2775
Homo sapiens Primates Gprotein GPROTEIN famplex_relations GNAI1 2770
Homo sapiens Primates Gprotein GPROTEIN famplex_relations GNAI2 2771
Homo sapiens Primates Gprotein GPROTEIN famplex_relations GNAI3 2773
Homo sapiens Primates Gprotein GPROTEIN famplex_relations GNAT1 2779
Homo sapiens Primates Gprotein GPROTEIN famplex_relations GNAT2 2780
Homo sapiens Primates Gprotein GPROTEIN famplex_relations GNAT3 346562
Homo sapiens Primates Gprotein GPROTEIN famplex_relations GNAZ 2781
Homo sapiens Primates Gprotein GPROTEIN famplex_relations GNAS 2778
Homo sapiens Primates Gprotein GPROTEIN famplex_relations GNAL 2774
Homo sapiens Primates Gprotein GPROTEIN famplex_relations GNAQ 2776
Homo sapiens Primates Gprotein GPROTEIN famplex_relations GNA11 2767
Homo sapiens Primates Gprotein GPROTEIN famplex_relations GNA14 9630
Homo sapiens Primates Gprotein GPROTEIN famplex_relations GNA15 2769
Homo sapiens Primates Gprotein GPROTEIN famplex_relations GNA12 2768
Homo sapiens Primates Gprotein GPROTEIN famplex_relations GNA13 10672
Homo sapiens Primates bets BET ncbigene_synonym DNER 92737
Homo sapiens Primates OXTR OXTR ncbigene_symbol OXTR 5021
Homo sapiens Primates KCNJ13 KCNJ13 ncbigene_symbol KCNJ13 3769
Homo sapiens Primates KCNJ KCNJ famplex_relations KCNJ1 3758
Homo sapiens Primates KCNJ KCNJ famplex_relations KCNJ10 3766
Homo sapiens Primates KCNJ KCNJ famplex_relations KCNJ11 3767
Homo sapiens Primates KCNJ KCNJ famplex_relations KCNJ12 3768
Homo sapiens Primates KCNJ KCNJ famplex_relations KCNJ14 3770
Homo sapiens Primates KCNJ KCNJ famplex_relations KCNJ15 3772
Homo sapiens Primates KCNJ KCNJ famplex_relations KCNJ16 3773
Homo sapiens Primates KCNJ KCNJ famplex_relations KCNJ18 100134444
Homo sapiens Primates KCNJ KCNJ famplex_relations KCNJ2 3759
Homo sapiens Primates KCNJ KCNJ famplex_relations KCNJ3 3760
Homo sapiens Primates KCNJ KCNJ famplex_relations KCNJ4 3761
Homo sapiens Primates KCNJ KCNJ famplex_relations KCNJ5 3762
Homo sapiens Primates KCNJ KCNJ famplex_relations KCNJ6 3763
Homo sapiens Primates KCNJ KCNJ famplex_relations KCNJ8 3764
Homo sapiens Primates KCNJ KCNJ famplex_relations KCNJ9 3765
Homo sapiens Primates RAS RAS famplex_relations KRAS 3845
Homo sapiens Primates RAS RAS famplex_relations HRAS 3265
Homo sapiens Primates RAS RAS famplex_relations NRAS 4893
Homo sapiens Primates MAPK7 MAPK7 ncbigene_symbol MAPK7 5598
Homo sapiens Primates RAF1 RAF1 ncbigene_symbol RAF1 5894
Homo sapiens Primates RAF1 RAF1 ncbigene_synonym RNASE3 6037
Homo sapiens Primates MARK1 MARK1 ncbigene_symbol MARK1 4139
Homo sapiens Primates TLR4 TLR4 ncbigene_symbol TLR4 7099
Homo sapiens Primates EIF2A EIF2A ncbigene_symbol EIF2A 83939
Homo sapiens Primates EIF2A EIF2A ncbigene_synonym EIF2S1 1965
Homo sapiens Primates NFKB NFKB ncbigene_synonym NFKB1 4790
Homo sapiens Primates NFKB NFKB famplex_relations RELA 5970
Homo sapiens Primates NFKB NFKB famplex_relations RELB 5971
Homo sapiens Primates NFKB NFKB famplex_relations REL 5966
Homo sapiens Primates NFKB NFKB famplex_relations NFKB2 4791
Homo sapiens Primates ERK1 ERK1 ncbigene_synonym MAPK3 5595
Homo sapiens Primates ERK1/2 ERK2 ncbigene_synonym MAPK1 5594
Homo sapiens Primates INF INF ncbigene_synonym CBLIF 2694
Homo sapiens Primates CREB CREB ncbigene_synonym CREB1 1385
Homo sapiens Primates CREB CREB famplex_relations CREB3 10488
Homo sapiens Primates CREB CREB famplex_relations CREB5 9586
Homo sapiens Primates CREB CREB famplex_relations CREB3L1 90993
Homo sapiens Primates CREB CREB famplex_relations CREB3L2 64764
Homo sapiens Primates CREB CREB famplex_relations CREB3L3 84699
Homo sapiens Primates CREB CREB famplex_relations CREB3L4 148327
Homo sapiens Primates CREB CREB famplex_relations CREM 1390
Homo sapiens Primates CREB CREB famplex_relations ATF1 466
Homo sapiens Primates CREB CREB famplex_relations ATF2 1386
Homo sapiens Primates MEF2 MEF2 ncbigene_synonym MEF2A 4205
Homo sapiens Primates MEF2 MEF2 ncbigene_synonym MYEF2 50804
Homo sapiens Primates MEF2 MEF2 famplex_relations MEF2C 4208
Homo sapiens Primates MEF2 MEF2 famplex_relations MEF2D 4209
Homo sapiens Primates MEF2 MEF2 famplex_relations MEF2B 100271849
Homo sapiens Primates RGS2 RGS2 ncbigene_symbol RGS2 5997
Homo sapiens Primates RGS2 RGS2 ncbigene_synonym RIEG2 6012
Homo sapiens Primates ADCYAP1 ADCYAP1 ncbigene_symbol ADCYAP1 116
Homo sapiens Primates actin ACTIN famplex_relations ACTA1 58
Homo sapiens Primates actin ACTIN famplex_relations ACTA2 59
Homo sapiens Primates actin ACTIN famplex_relations ACTB 60
Homo sapiens Primates actin ACTIN famplex_relations ACTC1 70
Homo sapiens Primates actin ACTIN famplex_relations ACTG1 71
Homo sapiens Primates actin ACTIN famplex_relations ACTG2 72
Homo sapiens Primates Glow GLOW ncbigene_synonym DICER1 23405

Chemical mentions

Word Match MeSH Name ChEBI
OXT OXT 1-({(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-(4-hydroxybenzyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-prolyl-L-leucylglycinamide chebi:7872
Ca2+ Ca2+ Ca(2+) chebi:29108
Ca2+ Ca2+ Ca(2+) chebi:29108
RAS RAS (1R)-N-(prop-2-yn-1-yl)indan-1-amine chebi:63620
Ca2+ Ca2+ Ca(2+) chebi:29108
OXT OXT 1-({(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-(4-hydroxybenzyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-prolyl-L-leucylglycinamide chebi:7872
Ca2+ Ca2+ Ca(2+) chebi:29108
Nucleus nucleus nucleus chebi:33252
Prostaglandins prostaglandins prostaglandins chebi:26333
molecule molecule chebi:25367

Disease mentions

Word Match MeSH Name DOID
Depressive disorder depressive disorder depressive disorder DOID:1596