VEGF signaling pathway

VEGF signaling pathway. VEGF binds to VEGFR-2 receptors on the surface of endothelial cells to promote cellular proliferation and migration, vascular permeability, and gene expression. Ultimately, VEGF induces angiogenesis through numerous pathways. This figure provides a simplification of VEGF signaling in angiogenesis with mention of key factors and pathways, including Src, SCK, Grb2, SHB, Ras-Raf-MEK-ERK, PLCγ/PKC, and PI3K-Akt [58,72]. Created with BioRender.com. VEGF, vascular endothelial growth factor; VEGFR, vascular endothelial growth factor receptor
VEGF signaling pathway
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Publication

Understanding the Role of Endothelial Cells in Glioblastoma: Mechanisms and Novel Treatments (2024) Gabrielle Hovis, et al. Int J Mol Sci. 2024 Jun;25(11). Figure: F3.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates FGF FGF famplex_relations FGF1 2246
Homo sapiens Primates FGF FGF famplex_relations FGF2 2247
Homo sapiens Primates FGF FGF famplex_relations FGF3 2248
Homo sapiens Primates FGF FGF famplex_relations FGF4 2249
Homo sapiens Primates FGF FGF famplex_relations FGF5 2250
Homo sapiens Primates FGF FGF famplex_relations FGF6 2251
Homo sapiens Primates FGF FGF famplex_relations FGF7 2252
Homo sapiens Primates FGF FGF famplex_relations FGF8 2253
Homo sapiens Primates FGF FGF famplex_relations FGF9 2254
Homo sapiens Primates FGF FGF famplex_relations FGF10 2255
Homo sapiens Primates FGF FGF famplex_relations FGF11 2256
Homo sapiens Primates FGF FGF famplex_relations FGF12 2257
Homo sapiens Primates FGF FGF famplex_relations FGF13 2258
Homo sapiens Primates FGF FGF famplex_relations FGF14 2259
Homo sapiens Primates FGF FGF famplex_relations FGF16 8823
Homo sapiens Primates FGF FGF famplex_relations FGF17 8822
Homo sapiens Primates FGF FGF famplex_relations FGF18 8817
Homo sapiens Primates FGF FGF famplex_relations FGF19 9965
Homo sapiens Primates FGF FGF famplex_relations FGF20 26281
Homo sapiens Primates FGF FGF famplex_relations FGF21 26291
Homo sapiens Primates FGF FGF famplex_relations FGF22 27006
Homo sapiens Primates FGF FGF famplex_relations FGF23 8074
Homo sapiens Primates FGFR FGFR famplex_relations FGFR1 2260
Homo sapiens Primates FGFR FGFR famplex_relations FGFR2 2263
Homo sapiens Primates FGFR FGFR famplex_relations FGFR3 2261
Homo sapiens Primates FGFR FGFR famplex_relations FGFR4 2264
Homo sapiens Primates FGFR FGFR famplex_relations FGFRL1 53834
Homo sapiens Primates FRS2 FRS2 ncbigene_symbol FRS2 10818
Homo sapiens Primates Ras RAS famplex_relations KRAS 3845
Homo sapiens Primates Ras RAS famplex_relations HRAS 3265
Homo sapiens Primates Ras RAS famplex_relations NRAS 4893
Homo sapiens Primates Raf RAF ncbigene_synonym ZHX2 22882
Homo sapiens Primates Raf RAF famplex_relations ARAF 369
Homo sapiens Primates Raf RAF famplex_relations BRAF 673
Homo sapiens Primates Raf RAF famplex_relations RAF1 5894
Homo sapiens Primates MEK MEK ncbigene_synonym MAP2K7 5609
Homo sapiens Primates MEK MEK famplex_relations MAP2K1 5604
Homo sapiens Primates MEK MEK famplex_relations MAP2K2 5605
Homo sapiens Primates Shc SHC ncbigene_synonym SHC1 6464
Homo sapiens Primates Shc SHC famplex_relations SHC2 25759
Homo sapiens Primates Shc SHC famplex_relations SHC3 53358
Homo sapiens Primates Shc SHC famplex_relations SHC4 399694
Homo sapiens Primates SHP2 SHP2 ncbigene_synonym PTPN11 5781
Homo sapiens Primates ERK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates ERK ERK ncbigene_synonym MAPK1 5594
Homo sapiens Primates ERK ERK famplex_relations MAPK3 5595
Homo sapiens Primates FRK FRK ncbigene_symbol FRK 2444
Homo sapiens Primates HIF-1a HIF-1A ncbigene_synonym HIF1A 3091
Homo sapiens Primates HIF-1ẞ HIF1 ncbigene_synonym SETD2 29072
Homo sapiens Primates HIF-1ẞ HIF1 famplex_relations ARNT 405
Homo sapiens Primates VEGF VEGF ncbigene_synonym VEGFA 7422
Homo sapiens Primates VEGF VEGF famplex_relations VEGFB 7423
Homo sapiens Primates VEGF VEGF famplex_relations VEGFC 7424
Homo sapiens Primates VEGF VEGF famplex_relations VEGFD 2277
Homo sapiens Primates VEGF VEGF famplex_relations PGF 5228
Homo sapiens Primates VEGFR-2 VEGFR2 ncbigene_synonym KDR 3791
Homo sapiens Primates Src SRC ncbigene_symbol SRC 6714
Homo sapiens Primates Src SRC famplex_relations FGR 2268
Homo sapiens Primates Src SRC famplex_relations FYN 2534
Homo sapiens Primates Src SRC famplex_relations YES1 7525
Homo sapiens Primates Grb2 GRB2 ncbigene_symbol GRB2 2885
Homo sapiens Primates SHB SHB ncbigene_symbol SHB 6461
Homo sapiens Primates PIK3 PIK3 ncbigene_synonym PIK3CG 5294
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates PKC PKC ncbigene_synonym PRRT2 112476
Homo sapiens Primates PKC PKC famplex_relations PRKCA 5578
Homo sapiens Primates PKC PKC famplex_relations PRKCB 5579
Homo sapiens Primates PKC PKC famplex_relations PRKCD 5580
Homo sapiens Primates PKC PKC famplex_relations PRKCE 5581
Homo sapiens Primates PKC PKC famplex_relations PRKCG 5582
Homo sapiens Primates PKC PKC famplex_relations PRKCH 5583
Homo sapiens Primates PKC PKC famplex_relations PRKCI 5584
Homo sapiens Primates PKC PKC famplex_relations PRKCQ 5588
Homo sapiens Primates PKC PKC famplex_relations PRKCZ 5590
Homo sapiens Primates PKC PKC famplex_relations PRKD3 23683
Homo sapiens Primates GSK3B GSK3B ncbigene_symbol GSK3B 2932
Homo sapiens Primates MTOR MTOR ncbigene_symbol MTOR 2475

Chemical mentions

Word Match MeSH Name ChEBI
Ras RAS (1R)-N-(prop-2-yn-1-yl)indan-1-amine chebi:63620
MEK MEK butan-2-one chebi:28398

Disease mentions

Word Match MeSH Name DOID