Antitumor effects of sophocarpine through multiple signaling pathways
Antitumor effects of sophocarpine through multiple signaling pathways. The antitumor activity of sophocarpine is mainly achieved by interfering with multiple signaling pathways in tumor cells. It can inhibit the proliferation and invasion of tumor cells, as well as their migration and metastasis. Additionally, sophocarpine can regulate the apoptotic signaling pathway in tumor cells, promoting their apoptosis and thus inhibiting tumor growth and spread. Furthermore, sophocarpine also exhibited immunomodulatory effects on tumors. Overall, as a natural compound, sophocarpine has promising potential in the field of cancer treatment
Publication
A review on the pharmacology, pharmacokinetics and toxicity of sophocarpine (2024) Shichao Wei, et al. Front Pharmacol. 2024;15(NA). Figure: F2.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | MEK | MEK | ncbigene_synonym | MAP2K7 | 5609 |
| Homo sapiens | Primates | MEK | MEK | famplex_relations | MAP2K1 | 5604 |
| Homo sapiens | Primates | MEK | MEK | famplex_relations | MAP2K2 | 5605 |
| Homo sapiens | Primates | Notch | NOTCH | famplex_relations | NOTCH1 | 4851 |
| Homo sapiens | Primates | Notch | NOTCH | famplex_relations | NOTCH2 | 4853 |
| Homo sapiens | Primates | Notch | NOTCH | famplex_relations | NOTCH3 | 4854 |
| Homo sapiens | Primates | Notch | NOTCH | famplex_relations | NOTCH4 | 4855 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CA | 5290 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CB | 5291 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CD | 5293 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CG | 5294 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R3 | 8503 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R4 | 30849 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R5 | 23533 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R6 | 146850 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R1 | 5295 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R2 | 5296 |
| Homo sapiens | Primates | miR-21 | MIR-21 | ncbigene_synonym | MIR21 | 406991 |
| Homo sapiens | Primates | ERK | ERK | ncbigene_synonym | EPHB2 | 2048 |
| Homo sapiens | Primates | ERK | ERK | ncbigene_synonym | MAPK1 | 5594 |
| Homo sapiens | Primates | ERK | ERK | famplex_relations | MAPK3 | 5595 |
| Homo sapiens | Primates | P38- | P38 | ncbigene_synonym | CRK | 1398 |
| Homo sapiens | Primates | P38- | P38 | ncbigene_synonym | MAPK14 | 1432 |
| Homo sapiens | Primates | P38- | P38 | ncbigene_synonym | AIMP2 | 7965 |
| Homo sapiens | Primates | P38- | P38 | ncbigene_synonym | GRAP2 | 9402 |
| Homo sapiens | Primates | P38- | P38 | ncbigene_synonym | AHSA1 | 10598 |
| Homo sapiens | Primates | P38- | P38 | ncbigene_synonym | POLDIP2 | 26073 |
| Homo sapiens | Primates | P38- | P38 | famplex_relations | MAPK11 | 5600 |
| Homo sapiens | Primates | P38- | P38 | famplex_relations | MAPK12 | 6300 |
| Homo sapiens | Primates | P38- | P38 | famplex_relations | MAPK13 | 5603 |
| Homo sapiens | Primates | N-cadherin | CDH2 | ncbigene_symbol | CDH2 | 1000 |
| Homo sapiens | Primates | VEGF | VEGF | ncbigene_synonym | VEGFA | 7422 |
| Homo sapiens | Primates | VEGF | VEGF | famplex_relations | VEGFB | 7423 |
| Homo sapiens | Primates | VEGF | VEGF | famplex_relations | VEGFC | 7424 |
| Homo sapiens | Primates | VEGF | VEGF | famplex_relations | VEGFD | 2277 |
| Homo sapiens | Primates | VEGF | VEGF | famplex_relations | PGF | 5228 |
| Homo sapiens | Primates | MMP9 | MMP9 | ncbigene_symbol | MMP9 | 4318 |
| Homo sapiens | Primates | Hey1 | HEY1 | ncbigene_symbol | HEY1 | 23462 |
| Homo sapiens | Primates | Hes1 | HES1 | ncbigene_symbol | HES1 | 3280 |
| Homo sapiens | Primates | Hes1 | HES1 | ncbigene_synonym | GATD3 | 8209 |
| Homo sapiens | Primates | P53 | P53 | ncbigene_synonym | TP53 | 7157 |
| Homo sapiens | Primates | P53 | P53 | famplex_relations | TP63 | 8626 |
| Homo sapiens | Primates | P53 | P53 | famplex_relations | TP73 | 7161 |
| Homo sapiens | Primates | MTOR | MTOR | ncbigene_symbol | MTOR | 2475 |
| Homo sapiens | Primates | GSK3 | GSK3 | famplex_relations | GSK3A | 2931 |
| Homo sapiens | Primates | GSK3 | GSK3 | famplex_relations | GSK3B | 2932 |
| Homo sapiens | Primates | AKT | AKT | ncbigene_synonym | AKT1 | 207 |
| Homo sapiens | Primates | AKT | AKT | famplex_relations | AKT2 | 208 |
| Homo sapiens | Primates | AKT | AKT | famplex_relations | AKT3 | 10000 |
| Homo sapiens | Primates | ATF | ATF | ncbigene_synonym | GDNF | 2668 |
| Homo sapiens | Primates | ATF | ATF | ncbigene_synonym | PLAU | 5328 |
| Homo sapiens | Primates | Bcl-2 | BCL-2 | ncbigene_synonym | BCL2 | 596 |
| Homo sapiens | Primates | Bcl-2/Bcl-xl | BC2 | ncbigene_synonym | CHMP2A | 27243 |
| Homo sapiens | Primates | PTEN | PTEN | ncbigene_symbol | PTEN | 5728 |
| Homo sapiens | Primates | PD-L1 | PD-L1 | ncbigene_synonym | CD274 | 29126 |
| Homo sapiens | Primates | EMT | EMT | ncbigene_synonym | ITK | 3702 |
| Homo sapiens | Primates | EMT | EMT | ncbigene_synonym | SLC22A3 | 6581 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| MEK | MEK | butan-2-one | chebi:28398 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|