Cerebrospinal Fluid Dysregulation via a SPAK and OSR1 Targeted Framework Nucleic Acid in Hydrocephalus

TSOs inhibit CSF hypersecretion by downregulating SPAK and OSR1 in ChP epithelial cells and inhibiting the phenotypic switch of ChP macrophages from M0 to M1 through MAPK signaling pathways, thus preventing hydrocephalus formation
Cerebrospinal Fluid Dysregulation via a SPAK and OSR1 Targeted Framework Nucleic Acid in Hydrocephalus
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Publication

Modulation of Cerebrospinal Fluid Dysregulation via a SPAK and OSR1 Targeted Framework Nucleic Acid in Hydrocephalus (2024) Qiguang Wang, et al. Adv Sci (Weinh). 2024 May;11(17). Scheme: S1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates CD86 CD86 ncbigene_symbol CD86 942
Homo sapiens Primates INOS↓ INOS ncbigene_synonym NOS2 4843
Homo sapiens Primates INOS↓ INOS ncbigene_synonym ISYNA1 51477
Homo sapiens Primates MAPK MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates CSF CSF ncbigene_synonym CSF2 1437
Homo sapiens Primates CSF CSF ncbigene_synonym LAMC2 3918
Homo sapiens Primates CSF1 CSF1 ncbigene_symbol CSF1 1435
Homo sapiens Primates OSR1 OSR1 ncbigene_symbol OSR1 130497
Homo sapiens Primates OSR1 OSR1 ncbigene_synonym OXSR1 9943
Homo sapiens Primates OSR1 OSR1 ncbigene_synonym OSER1 51526
Homo sapiens Primates GSF↓ GSF ncbigene_synonym PDX1 3651

Chemical mentions

Word Match MeSH Name ChEBI
CSF CSF L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine chebi:191852

Disease mentions

Word Match MeSH Name DOID
Hydrocephalus hydrocephalus hydrocephalus DOID:10908