Wnt/Beta-catenin pathway
The Wnt/β-catenin pathway. In the absence of Wnt ligands, the AXIN, GSK-3β, and APC degradation complex phosphorylates β-catenin and β-TrCP ubiquitinates β-catenin, resulting in proteasome-mediated degradation. A repressive complex (TCF/LEF and Groucho) represses target genes in the absence of β-catenin. When Wnt ligands bind to the Wnt receptor (FZD) and its co-receptor (LRP), β-catenin is liberated from the degradation complex and translocates to the nucleus, where it replaces Groucho and forms an active complex with TCF/LEF to activate the target genes. Ginsenosides (Rg1, Rg3, Rh2) decrease the protein level of β-catenin
Publication
Ginseng-derived compounds as potential anticancer agents targeting cancer stem cells (2024) Ji-Sun Lee, et al. J Ginseng Res. 2024 Mar 12;48(3). Figure: F2.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | (Rb1, | RB1 | ncbigene_symbol | RB1 | 5925 |
| Homo sapiens | Primates | (Rb1, | RB1 | ncbigene_synonym | RBM45 | 129831 |
| Homo sapiens | Primates | Rh2) | RH2 | ncbigene_synonym | RHAG | 6005 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT1 | 7471 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT2 | 7472 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT2B | 7482 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT3 | 7473 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT3A | 89780 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT4 | 54361 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT6 | 7475 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT7A | 7476 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT7B | 7477 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT8A | 7478 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT8B | 7479 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT9A | 7483 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT9B | 7484 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT10A | 80326 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT10B | 7480 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT11 | 7481 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT16 | 51384 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT5A | 7474 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT5B | 81029 |
| Homo sapiens | Primates | FZD | FZD | famplex_relations | FZD1 | 8321 |
| Homo sapiens | Primates | FZD | FZD | famplex_relations | FZD10 | 11211 |
| Homo sapiens | Primates | FZD | FZD | famplex_relations | FZD2 | 2535 |
| Homo sapiens | Primates | FZD | FZD | famplex_relations | FZD3 | 7976 |
| Homo sapiens | Primates | FZD | FZD | famplex_relations | FZD4 | 8322 |
| Homo sapiens | Primates | FZD | FZD | famplex_relations | FZD5 | 7855 |
| Homo sapiens | Primates | FZD | FZD | famplex_relations | FZD6 | 8323 |
| Homo sapiens | Primates | FZD | FZD | famplex_relations | FZD7 | 8324 |
| Homo sapiens | Primates | FZD | FZD | famplex_relations | FZD8 | 8325 |
| Homo sapiens | Primates | FZD | FZD | famplex_relations | FZD9 | 8326 |
| Homo sapiens | Primates | LRP | LRP | ncbigene_synonym | RPSA | 3921 |
| Homo sapiens | Primates | LRP | LRP | ncbigene_synonym | LRP1 | 4035 |
| Homo sapiens | Primates | LRP | LRP | ncbigene_synonym | PTPRA | 5786 |
| Homo sapiens | Primates | LRP | LRP | ncbigene_synonym | MVP | 9961 |
| Homo sapiens | Primates | Dvl | DVL | ncbigene_synonym | DVL1 | 1855 |
| Homo sapiens | Primates | Dvl | DVL | ncbigene_synonym | DVL1P1 | 8215 |
| Homo sapiens | Primates | Dvl | DVL | famplex_relations | DVL2 | 1856 |
| Homo sapiens | Primates | Dvl | DVL | famplex_relations | DVL3 | 1857 |
| Homo sapiens | Primates | B-catenin | CTNNB1 | ncbigene_symbol | CTNNB1 | 1499 |
| Homo sapiens | Primates | B-TrCP | B-TRCP | ncbigene_synonym | BTRC | 8945 |
| Homo sapiens | Primates | GSK3ẞ | GSK3 | famplex_relations | GSK3A | 2931 |
| Homo sapiens | Primates | GSK3ẞ | GSK3 | famplex_relations | GSK3B | 2932 |
| Homo sapiens | Primates | APC | APC | ncbigene_symbol | APC | 324 |
| Homo sapiens | Primates | APC | APC | ncbigene_synonym | PROC | 5624 |
| Homo sapiens | Primates | AXIN | AXIN | ncbigene_synonym | AXIN1 | 8312 |
| Homo sapiens | Primates | AXIN | AXIN | famplex_relations | AXIN2 | 8313 |
| Homo sapiens | Primates | TCF | TCF | ncbigene_synonym | HNF4A | 3172 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| OFF | Off | N,N-diethyl-3-methylbenzamide | chebi:7071 | |
| ginsenosides | ginsenosides | chebi:74978 | ||
| nucleus | nucleus | nucleus | chebi:33252 | |
| nucleus | nucleus | nucleus | chebi:33252 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|