KEGG pathway (hsa04151 P13K-AKT signaling pathway)

KEGG pathway (hsa04151 P13K-AKT signaling pathway). The red nodes represent up-regulated genes while the green ones are down-regulated genes. Two genes are linked together with solid lines if they function together in the present KEGG pathways while those connected with dotted lines do not function together
KEGG pathway (hsa04151 P13K-AKT signaling pathway)
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Publication

Exploring the Mechanisms of Traditional Chinese Herbal Therapy in Gastric Cancer: A Comprehensive Network Pharmacology Study of the Tiao-Yuan-Tong-Wei decoction (2024) Juan Chen, et al. Pharmaceuticals (Basel). 2024 Apr;17(4). Figure: F7.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates mTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates IF4E IF4E ncbigene_synonym EIF4E2 9470
Homo sapiens Primates AMP AMP ncbigene_synonym APRT 353
Homo sapiens Primates AMP AMP ncbigene_synonym MFAP1 4236
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA1 5562
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA2 5563
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAB1 5564
Homo sapiens Primates AMPK AMPK famplex_relations PRKAB2 5565
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG1 5571
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG2 51422
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG3 53632
Homo sapiens Primates Rheb RHEB ncbigene_symbol RHEB 6009
Homo sapiens Primates Rheb RHEB ncbigene_synonym RHEBP1 6008
Homo sapiens Primates TOR TOR ncbigene_synonym RORC 6097
Homo sapiens Primates TSC2 TSC2 ncbigene_symbol TSC2 7249
Homo sapiens Primates eIF4B EIF4B ncbigene_symbol EIF4B 1975
Homo sapiens Primates S6K1/2 S6K1 ncbigene_synonym RPS6KB1 6198
Homo sapiens Primates por POR ncbigene_symbol POR 5447
Homo sapiens Primates por POR ncbigene_synonym VDAC2 7417
Homo sapiens Primates SOS SOS ncbigene_synonym XYLT2 64132
Homo sapiens Primates SOS SOS famplex_relations SOS1 6654
Homo sapiens Primates SOS SOS famplex_relations SOS2 6655
Homo sapiens Primates eNOS ENOS ncbigene_synonym NOS3 4846
Homo sapiens Primates eNOS ENOS ncbigene_synonym ENO4 387712
Homo sapiens Primates PKC PKC ncbigene_synonym PRRT2 112476
Homo sapiens Primates PKC PKC famplex_relations PRKCA 5578
Homo sapiens Primates PKC PKC famplex_relations PRKCB 5579
Homo sapiens Primates PKC PKC famplex_relations PRKCD 5580
Homo sapiens Primates PKC PKC famplex_relations PRKCE 5581
Homo sapiens Primates PKC PKC famplex_relations PRKCG 5582
Homo sapiens Primates PKC PKC famplex_relations PRKCH 5583
Homo sapiens Primates PKC PKC famplex_relations PRKCI 5584
Homo sapiens Primates PKC PKC famplex_relations PRKCQ 5588
Homo sapiens Primates PKC PKC famplex_relations PRKCZ 5590
Homo sapiens Primates PKC PKC famplex_relations PRKD3 23683
Homo sapiens Primates PION PION ncbigene_synonym GSAP 54103
Homo sapiens Primates SCK SCK ncbigene_synonym SHC2 25759
Homo sapiens Primates Actin ACTIN famplex_relations ACTA1 58
Homo sapiens Primates Actin ACTIN famplex_relations ACTA2 59
Homo sapiens Primates Actin ACTIN famplex_relations ACTB 60
Homo sapiens Primates Actin ACTIN famplex_relations ACTC1 70
Homo sapiens Primates Actin ACTIN famplex_relations ACTG1 71
Homo sapiens Primates Actin ACTIN famplex_relations ACTG2 72
Homo sapiens Primates MAPK MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates Raf-1 RAF-1 ncbigene_synonym RAF1 5894
Homo sapiens Primates MEK MEK ncbigene_synonym MAP2K7 5609
Homo sapiens Primates MEK MEK famplex_relations MAP2K1 5604
Homo sapiens Primates MEK MEK famplex_relations MAP2K2 5605
Homo sapiens Primates PP2A PP2A ncbigene_synonym PTPA 5524
Homo sapiens Primates PEPCK PEPCK ncbigene_synonym PCK2 5106
Homo sapiens Primates CTM CTM ncbigene_synonym HSF4 3299
Homo sapiens Primates CDK CDK famplex_relations CDKL1 8814
Homo sapiens Primates CDK CDK famplex_relations CDKL2 8999
Homo sapiens Primates CDK CDK famplex_relations CDKL3 51265
Homo sapiens Primates CDK CDK famplex_relations CDKL4 344387
Homo sapiens Primates CDK CDK famplex_relations CDKL5 6792
Homo sapiens Primates CDK CDK famplex_relations CDK3 1018
Homo sapiens Primates CDK CDK famplex_relations CDK4 1019
Homo sapiens Primates CDK CDK famplex_relations CDK5 1020
Homo sapiens Primates CDK CDK famplex_relations CDK6 1021
Homo sapiens Primates CDK CDK famplex_relations CDK7 1022
Homo sapiens Primates CDK CDK famplex_relations CDK8 1024
Homo sapiens Primates CDK CDK famplex_relations CDK9 1025
Homo sapiens Primates CDK CDK famplex_relations CDK10 8558
Homo sapiens Primates CDK CDK famplex_relations CDK11A 728642
Homo sapiens Primates CDK CDK famplex_relations CDK11B 984
Homo sapiens Primates CDK CDK famplex_relations CDK12 51755
Homo sapiens Primates CDK CDK famplex_relations CDK13 8621
Homo sapiens Primates CDK CDK famplex_relations CDK14 5218
Homo sapiens Primates CDK CDK famplex_relations CDK15 65061
Homo sapiens Primates CDK CDK famplex_relations CDK16 5127
Homo sapiens Primates CDK CDK famplex_relations CDK17 5128
Homo sapiens Primates CDK CDK famplex_relations CDK18 5129
Homo sapiens Primates CDK CDK famplex_relations CDK19 23097
Homo sapiens Primates CDK CDK famplex_relations CDK20 23552
Homo sapiens Primates CDK CDK famplex_relations CDK1 983
Homo sapiens Primates CDK CDK famplex_relations CDK2 1017
Homo sapiens Primates RBL2 RBL2 ncbigene_symbol RBL2 5934
Homo sapiens Primates mTORC2 MTORC2 famplex_relations MAPKAP1 79109
Homo sapiens Primates mTORC2 MTORC2 famplex_relations RICTOR 253260
Homo sapiens Primates mTORC2 MTORC2 famplex_relations MLST8 64223
Homo sapiens Primates PHLPP PHLPP ncbigene_synonym PHLPP1 23239
Homo sapiens Primates Bim BIM ncbigene_synonym BCL2L11 10018
Homo sapiens Primates BAD BAD ncbigene_symbol BAD 572
Homo sapiens Primates BCR BCR ncbigene_symbol BCR 613
Homo sapiens Primates BCR BCR ncbigene_synonym RN7SL263P 106480993
Homo sapiens Primates Syl SYL ncbigene_synonym SYCN 342898
Homo sapiens Primates CD19 CD19 ncbigene_symbol CD19 930
Homo sapiens Primates BCAP BCAP ncbigene_synonym PHF11 51131
Homo sapiens Primates BCAP BCAP ncbigene_synonym PIK3AP1 118788
Homo sapiens Primates JAK JAK famplex_relations JAK1 3716
Homo sapiens Primates JAK JAK famplex_relations JAK2 3717
Homo sapiens Primates JAK JAK famplex_relations JAK3 3718
Homo sapiens Primates JAK JAK famplex_relations TYK2 7297
Homo sapiens Primates BCM BCM ncbigene_synonym TNFRSF17 608
Homo sapiens Primates FAK FAK ncbigene_synonym PTK2 5747
Homo sapiens Primates ITGA ITGA famplex_relations ITGA1 3672
Homo sapiens Primates ITGA ITGA famplex_relations ITGA10 8515
Homo sapiens Primates ITGA ITGA famplex_relations ITGA11 22801
Homo sapiens Primates ITGA ITGA famplex_relations ITGA2 3673
Homo sapiens Primates ITGA ITGA famplex_relations ITGA2B 3674
Homo sapiens Primates ITGA ITGA famplex_relations ITGA3 3675
Homo sapiens Primates ITGA ITGA famplex_relations ITGA4 3676
Homo sapiens Primates ITGA ITGA famplex_relations ITGA5 3678
Homo sapiens Primates ITGA ITGA famplex_relations ITGA6 3655
Homo sapiens Primates ITGA ITGA famplex_relations ITGA7 3679
Homo sapiens Primates ITGA ITGA famplex_relations ITGA8 8516
Homo sapiens Primates ITGA ITGA famplex_relations ITGA9 3680
Homo sapiens Primates ITGA ITGA famplex_relations ITGAD 3681
Homo sapiens Primates ITGA ITGA famplex_relations ITGAE 3682
Homo sapiens Primates ITGA ITGA famplex_relations ITGAL 3683
Homo sapiens Primates ITGA ITGA famplex_relations ITGAM 3684
Homo sapiens Primates ITGA ITGA famplex_relations ITGAV 3685
Homo sapiens Primates ITGA ITGA famplex_relations ITGAX 3687
Homo sapiens Primates HSP90 HSP90 ncbigene_synonym HSP90AA1 3320
Homo sapiens Primates HSP90 HSP90 famplex_relations HSP90B1 7184
Homo sapiens Primates HSP90 HSP90 famplex_relations TRAP1 10131
Homo sapiens Primates HSP90 HSP90 famplex_relations HSP90AB1 3326
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL10 3627
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL11 6373
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL12 6387
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL13 10563
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL14 9547
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL9 4283
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations PF4 5196
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL1 2919
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL2 2920
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL3 2921
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL5 6374
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL6 6372
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL8 3576
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations PPBP 5473
Homo sapiens Primates GPCR GPCR ncbigene_synonym FZD4 8322
Homo sapiens Primates GPCR GPCR ncbigene_synonym NMUR1 10316
Homo sapiens Primates GPCR GPCR ncbigene_synonym LPAR3 23566
Homo sapiens Primates GPCR GPCR ncbigene_synonym LGR6 59352
Homo sapiens Primates GPCR GPCR ncbigene_synonym MRGPRX3 117195
Homo sapiens Primates GPCR GPCR ncbigene_synonym MRGPRX4 117196
Homo sapiens Primates GPCR GPCR ncbigene_synonym GPR151 134391
Homo sapiens Primates GPCR GPCR ncbigene_synonym OXER1 165140
Homo sapiens Primates GPCR GPCR ncbigene_synonym GPRC6A 222545
Homo sapiens Primates GPCR GPCR ncbigene_synonym MRGPRX1 259249
Homo sapiens Primates GPCR GPCR ncbigene_synonym VN1R17P 441931
Homo sapiens Primates GPCR GPCR ncbigene_synonym GPR166P 442206
Homo sapiens Primates GPCR GPCR famplex_relations GRM1 2911
Homo sapiens Primates GPCR GPCR famplex_relations GRM2 2912
Homo sapiens Primates GPCR GPCR famplex_relations GRM3 2913
Homo sapiens Primates GPCR GPCR famplex_relations GRM4 2914
Homo sapiens Primates GPCR GPCR famplex_relations GRM5 2915
Homo sapiens Primates GPCR GPCR famplex_relations GRM6 2916
Homo sapiens Primates GPCR GPCR famplex_relations GRM7 2917
Homo sapiens Primates GPCR GPCR famplex_relations GRM8 2918
Homo sapiens Primates GPCR GPCR famplex_relations CASR 846
Homo sapiens Primates GPCR GPCR famplex_relations GABBR1 2550
Homo sapiens Primates GPCR GPCR famplex_relations GABBR2 9568
Homo sapiens Primates GPCR GPCR famplex_relations GPR156 165829
Homo sapiens Primates GPCR GPCR famplex_relations GPR158 57512
Homo sapiens Primates GPCR GPCR famplex_relations GPR179 440435
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5A 9052
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5B 51704
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5C 55890
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5D 55507
Homo sapiens Primates PI(4, PI4 ncbigene_synonym SERPINA4 5267
Homo sapiens Primates CREB CREB ncbigene_synonym CREB1 1385
Homo sapiens Primates CREB CREB famplex_relations CREB3 10488
Homo sapiens Primates CREB CREB famplex_relations CREB5 9586
Homo sapiens Primates CREB CREB famplex_relations CREB3L1 90993
Homo sapiens Primates CREB CREB famplex_relations CREB3L2 64764
Homo sapiens Primates CREB CREB famplex_relations CREB3L3 84699
Homo sapiens Primates CREB CREB famplex_relations CREB3L4 148327
Homo sapiens Primates CREB CREB famplex_relations CREM 1390
Homo sapiens Primates CREB CREB famplex_relations ATF1 466
Homo sapiens Primates CREB CREB famplex_relations ATF2 1386
Homo sapiens Primates Mcl-1 MCL-1 ncbigene_synonym MCL1 4170
Homo sapiens Primates RXR RXR famplex_relations RXRA 6256
Homo sapiens Primates RXR RXR famplex_relations RXRB 6257
Homo sapiens Primates RXR RXR famplex_relations RXRG 6258
Homo sapiens Primates IKK IKK famplex_relations CHUK 1147
Homo sapiens Primates IKK IKK famplex_relations IKBKB 3551
Homo sapiens Primates IKK IKK famplex_relations IKBKG 8517
Homo sapiens Primates IKK IKK famplex_relations IKBKE 9641
Homo sapiens Primates IKK IKK famplex_relations TBK1 29110
Homo sapiens Primates c-Myb C-MYB ncbigene_synonym MYB 4602
Homo sapiens Primates MDM MDM ncbigene_synonym SLURP1 57152
Homo sapiens Primates p53 P53 ncbigene_synonym TP53 7157
Homo sapiens Primates p53 P53 famplex_relations TP63 8626
Homo sapiens Primates p53 P53 famplex_relations TP73 7161

Chemical mentions

Word Match MeSH Name ChEBI
AMP AMP 5'-O-phosphonatoadenosine chebi:456215
Protein Protein a protein chebi:16541
Raptor Raptor rac-ammonium 5-(methoxymethyl)-2-[4-methyl-5-oxo-4-(propan-2-yl)-4,5-dihydro-1H-imidazol-2-yl]pyridine-3-carboxylate chebi:133232
PION pion pion chebi:36348
MEK MEK butan-2-one chebi:28398
CTM CTM 7beta-(2-amino-1,3-thiazol-4-yl)acetamido-3-[({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl]-3,4-didehydrocepham-4-carboxylic acid chebi:355510
DNA DNA deoxyribonucleic acids chebi:16991
DNA DNA deoxyribonucleic acids chebi:16991
DNA DNA deoxyribonucleic acids chebi:16991
DNA DNA deoxyribonucleic acids chebi:16991
Bim bim benzimidazol-1-ide chebi:33173
DNA DNA deoxyribonucleic acids chebi:16991
DNA DNA deoxyribonucleic acids chebi:16991

Disease mentions

Word Match MeSH Name DOID