Androgen receptor structure and signaling pathway in PCa

Androgen receptor structure and signaling pathway in PCa. (A) Representation of protein domains of AR. It comprises domains for transcription factor binding, DNA recognition, hormone binding/chaperone binding, and a nuclear localization signal (NLS). (B) Example crosstalk between AR and SPDEF. Interaction of DHT and AR leads to activation of SPDEF and its transport to the nucleus. The complex AR/SPDEF interacts with RNApol, thus activating the transcription of target genes, such as ZBTB46, TGFBI, and CCL2. In turn, SPDEF targets genes, such as ZBTB46, leading to upregulation of PTGS1, LIF, Snail, and CCL2 proteins involved in certain processes, such as tumor progression and metastasis. SPEDF activation leads to the activation of inflammatory-associated gene and cancer pathophysiology, cell proliferation, EMT, and metastasis that result in CRPC-NE differentiation and progression

Publication

Transcription Factors in Prostate Cancer: Insights for Disease Development and Diagnostic and Therapeutic Approaches (2024) Karla C. S. Silva, et al. Genes (Basel). 2024 Apr;15(4). Figure: F2. Homo sapiens

Disease mentions