Working Model: HDAC6 maintains primordial follicle dormancy
Working Model: HDAC6 maintains primordial follicle dormancy. HDAC6 is highly expressed in primordial follicles. HDAC6 forms a protein complex with NGF, BDNF, TGF-β, and TSC2. HADC6 deacetylates NGF, and acetylated NGF is degraded by ubiquitination. Low levels of NGF cannot activate the mTOR signaling pathway, rendering primordial follicles dormant. HDAC6 gradually decreases during the development of primordial to primary follicles. NGF is not modified by deacetylation and cannot be degraded by ubiquitination. The elevated NGF activates the mTOR signaling pathway; thus, primordial follicles are activated to develop into primary follicles
Publication
HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy (2024) Tuo Zhang, et al. Theranostics. 2024;14(6). Figure: F9.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | TSC2 | TSC2 | ncbigene_symbol | TSC2 | 7249 |
| Homo sapiens | Primates | NGF | NGF | ncbigene_symbol | NGF | 4803 |
| Homo sapiens | Primates | BDNF | BDNF | ncbigene_symbol | BDNF | 627 |
| Homo sapiens | Primates | BDNF | BDNF | ncbigene_synonym | BDNF-AS | 497258 |
| Homo sapiens | Primates | TGF-B | TGFB | ncbigene_synonym | TGFB1 | 7040 |
| Homo sapiens | Primates | TGF-B | TGFB | famplex_relations | TGFB2 | 7042 |
| Homo sapiens | Primates | TGF-B | TGFB | famplex_relations | TGFB3 | 7043 |
| Homo sapiens | Primates | HDAC6 | HDAC6 | ncbigene_symbol | HDAC6 | 10013 |
| Homo sapiens | Primates | PmF | PMF | ncbigene_synonym | PRB1 | 5542 |
| Homo sapiens | Primates | ZIP | ZIP | ncbigene_synonym | DAPK3 | 1613 |
| Homo sapiens | Primates | ZIP | ZIP | ncbigene_synonym | ZGPAT | 84619 |
| Homo sapiens | Primates | TF | TF | ncbigene_symbol | TF | 7018 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
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