Compound-target-pathway network

Compound-target-pathway network. Green circle nodes represent chemical compounds, yellow quadrilateral nodes represent targets, and orange circle nodes represent pathways. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Compound-target-pathway network
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Publication

Revealing the active ingredients and mechanism of P. sibiricumm in non-small-cell lung cancer based on UPLC-Q-TOF-MS/MS, network pharmacology, and molecular docking (2024) Kaili Guo, et al. Heliyon. 2024 Apr 15;10(7). Figure: F9.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates Fox FOX famplex_relations FOXG1 2290
Homo sapiens Primates Fox FOX famplex_relations FOXH1 8928
Homo sapiens Primates Fox FOX famplex_relations FOXM1 2305
Homo sapiens Primates Fox FOX famplex_relations FOXQ1 94234
Homo sapiens Primates Fox FOX famplex_relations FOXS1 2307
Homo sapiens Primates Fox FOX famplex_relations FOXA1 3169
Homo sapiens Primates Fox FOX famplex_relations FOXA2 3170
Homo sapiens Primates Fox FOX famplex_relations FOXA3 3171
Homo sapiens Primates Fox FOX famplex_relations FOXB1 27023
Homo sapiens Primates Fox FOX famplex_relations FOXB2 442425
Homo sapiens Primates Fox FOX famplex_relations FOXC1 2296
Homo sapiens Primates Fox FOX famplex_relations FOXC2 2303
Homo sapiens Primates Fox FOX famplex_relations FOXD1 2297
Homo sapiens Primates Fox FOX famplex_relations FOXD2 2306
Homo sapiens Primates Fox FOX famplex_relations FOXD3 27022
Homo sapiens Primates Fox FOX famplex_relations FOXD4 2298
Homo sapiens Primates Fox FOX famplex_relations FOXE1 2304
Homo sapiens Primates Fox FOX famplex_relations FOXE3 2301
Homo sapiens Primates Fox FOX famplex_relations FOXF1 2294
Homo sapiens Primates Fox FOX famplex_relations FOXF2 2295
Homo sapiens Primates Fox FOX famplex_relations FOXI1 2299
Homo sapiens Primates Fox FOX famplex_relations FOXI2 399823
Homo sapiens Primates Fox FOX famplex_relations FOXI3 344167
Homo sapiens Primates Fox FOX famplex_relations FOXJ1 2302
Homo sapiens Primates Fox FOX famplex_relations FOXJ2 55810
Homo sapiens Primates Fox FOX famplex_relations FOXJ3 22887
Homo sapiens Primates Fox FOX famplex_relations FOXK1 221937
Homo sapiens Primates Fox FOX famplex_relations FOXK2 3607
Homo sapiens Primates Fox FOX famplex_relations FOXL1 2300
Homo sapiens Primates Fox FOX famplex_relations FOXL2 668
Homo sapiens Primates Fox FOX famplex_relations FOXN1 8456
Homo sapiens Primates Fox FOX famplex_relations FOXN2 3344
Homo sapiens Primates Fox FOX famplex_relations FOXN3 1112
Homo sapiens Primates Fox FOX famplex_relations FOXN4 121643
Homo sapiens Primates Fox FOX famplex_relations FOXO1 2308
Homo sapiens Primates Fox FOX famplex_relations FOXO3 2309
Homo sapiens Primates Fox FOX famplex_relations FOXO4 4303
Homo sapiens Primates Fox FOX famplex_relations FOXO6 100132074
Homo sapiens Primates Fox FOX famplex_relations FOXP1 27086
Homo sapiens Primates Fox FOX famplex_relations FOXP2 93986
Homo sapiens Primates Fox FOX famplex_relations FOXP3 50943
Homo sapiens Primates Fox FOX famplex_relations FOXP4 116113
Homo sapiens Primates Fox FOX famplex_relations FOXR1 283150
Homo sapiens Primates Fox FOX famplex_relations FOXR2 139628
Homo sapiens Primates Fox FOX famplex_relations FOXD4L1 200350
Homo sapiens Primates Fox FOX famplex_relations FOXD4L3 286380
Homo sapiens Primates Fox FOX famplex_relations FOXD4L4 349334
Homo sapiens Primates Fox FOX famplex_relations FOXD4L5 653427
Homo sapiens Primates Fox FOX famplex_relations FOXD4L6 653404
Homo sapiens Primates FGF2 FGF2 ncbigene_symbol FGF2 2247
Homo sapiens Primates FGF2 FGF2 ncbigene_synonym FGF13 2258
Homo sapiens Primates TERT TERT ncbigene_symbol TERT 7015
Homo sapiens Primates KIT KIT ncbigene_symbol KIT 3815
Homo sapiens Primates PPARA PPARA ncbigene_symbol PPARA 5465
Homo sapiens Primates PIK3CA PIK3CA ncbigene_symbol PIK3CA 5290
Homo sapiens Primates FGF3 FGF3 ncbigene_symbol FGF3 2248
Homo sapiens Primates KDR KDR ncbigene_symbol KDR 3791
Homo sapiens Primates THRA THRA ncbigene_symbol THRA 7067
Homo sapiens Primates STAT3 STAT3 ncbigene_symbol STAT3 6774
Homo sapiens Primates MAP2K1 MAP2K1 ncbigene_symbol MAP2K1 5604
Homo sapiens Primates EGFR EGFR ncbigene_symbol EGFR 1956
Homo sapiens Primates PPARG PPARG ncbigene_symbol PPARG 5468
Homo sapiens Primates PARP1 PARP1 ncbigene_symbol PARP1 142
Homo sapiens Primates GRB2 GRB2 ncbigene_symbol GRB2 2885
Homo sapiens Primates JUN JUN ncbigene_symbol JUN 3725
Homo sapiens Primates JUN JUN famplex_relations JUNB 3726
Homo sapiens Primates JUN JUN famplex_relations JUND 3727
Homo sapiens Primates PD-1 PD-1 ncbigene_synonym PDCD1 5133
Homo sapiens Primates PD-1 PD-1 ncbigene_synonym RPL17 6139
Homo sapiens Primates PD-1 PD-1 ncbigene_synonym RPL17-C18orf32 100526842
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL10 3627
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL11 6373
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL12 6387
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL13 10563
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL14 9547
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL9 4283
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations PF4 5196
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL1 2919
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL2 2920
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL3 2921
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL5 6374
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL6 6372
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL8 3576
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations PPBP 5473
Homo sapiens Primates THRB THRB ncbigene_symbol THRB 7068
Homo sapiens Primates SRC SRC ncbigene_symbol SRC 6714
Homo sapiens Primates SRC SRC famplex_relations FGR 2268
Homo sapiens Primates SRC SRC famplex_relations FYN 2534
Homo sapiens Primates SRC SRC famplex_relations YES1 7525
Homo sapiens Primates MAPK14 MAPK14 ncbigene_symbol MAPK14 1432
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates PRKCA PRKCA ncbigene_symbol PRKCA 5578
Homo sapiens Primates MTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates HSP90AA1 HSP90AA1 ncbigene_symbol HSP90AA1 3320
Homo sapiens Primates Rap1 RAP1 ncbigene_synonym RAP1A 5906
Homo sapiens Primates Rap1 RAP1 ncbigene_synonym RABGEF1 27342
Homo sapiens Primates Rap1 RAP1 ncbigene_synonym TERF2IP 54386
Homo sapiens Primates Rap1 RAP1 famplex_relations RAP1B 5908
Homo sapiens Primates SIRT1 SIRT1 ncbigene_symbol SIRT1 23411
Homo sapiens Primates TNF TNF ncbigene_symbol TNF 7124
Homo sapiens Primates ESR1 ESR1 ncbigene_symbol ESR1 2099
Homo sapiens Primates AR AR ncbigene_symbol AR 367
Homo sapiens Primates MMP9 MMP9 ncbigene_symbol MMP9 4318
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA1 5562
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA2 5563
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAB1 5564
Homo sapiens Primates AMPK AMPK famplex_relations PRKAB2 5565
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG1 5571
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG2 51422
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG3 53632
Homo sapiens Primates IL2 IL2 ncbigene_symbol IL2 3558
Homo sapiens Primates CASP3 CASP3 ncbigene_symbol CASP3 836
Homo sapiens Primates PTGS2 PTGS2 ncbigene_symbol PTGS2 5743
Homo sapiens Primates CDK1 CDK1 ncbigene_symbol CDK1 983
Homo sapiens Primates TN TN famplex_relations TNC 3371
Homo sapiens Primates TN TN famplex_relations TNN 63923
Homo sapiens Primates TN TN famplex_relations TNR 7143
Homo sapiens Primates TN TN famplex_relations TNXB 7148
Homo sapiens Primates th TH ncbigene_symbol TH 7054
Homo sapiens Primates MAPK MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates VEGFA VEGFA ncbigene_symbol VEGFA 7422
Homo sapiens Primates trap TRAP ncbigene_symbol TRAP 100187907
Homo sapiens Primates trap TRAP ncbigene_synonym ACP5 54
Homo sapiens Primates trap TRAP ncbigene_synonym CD40LG 959
Homo sapiens Primates trap TRAP ncbigene_synonym TRAF2 7186
Homo sapiens Primates trap TRAP ncbigene_synonym TRRAP 8295
Homo sapiens Primates trap TRAP ncbigene_synonym TDRD7 23424
Homo sapiens Primates trap TRAP ncbigene_synonym SCYL1 57410
Homo sapiens Primates BCL2 BCL2 ncbigene_symbol BCL2 596
Homo sapiens Primates MDM2 MDM2 ncbigene_symbol MDM2 4193
Homo sapiens Primates RAF1 RAF1 ncbigene_symbol RAF1 5894
Homo sapiens Primates RAF1 RAF1 ncbigene_synonym RNASE3 6037
Homo sapiens Primates IGF1R IGF1R ncbigene_symbol IGF1R 3480
Homo sapiens Primates MDM4 MDM4 ncbigene_symbol MDM4 4194
Homo sapiens Primates PTPRC PTPRC ncbigene_symbol PTPRC 5788

Chemical mentions

Word Match MeSH Name ChEBI
MET Met methionine chebi:16811

Disease mentions

Word Match MeSH Name DOID
cancer cancer cancer DOID:162
Hepatitis hepatitis hepatitis DOID:2237
disease disease disease DOID:4
disease disease disease DOID:4
cancer cancer cancer DOID:162
cancer cancer cancer DOID:162
cancer cancer cancer DOID:162
Hepatitis hepatitis hepatitis DOID:2237
cancer cancer cancer DOID:162
cancer cancer cancer DOID:162
Hepatitis C hepatitis C hepatitis C DOID:1883
liver disease liver disease liver disease DOID:409
Breast cancer breast cancer breast cancer DOID:1612
Colorectal cancer colorectal cancer colorectal cancer DOID:9256
Prostate cancer prostate cancer prostate cancer DOID:10283