Hippo signalling pathway and its impact on eye diseases

Functions of the Hippo pathway in mammalian eye diseases. Summary of eye diseases caused by dysregulation of the Hippo pathway. The components within the dotted rectangle indicate components of the canonical kinase cascade. Dysregulation of the Hippo pathway has been found in a variety of eye diseases and is involved in the regulation of the occurrence or progression of these diseases. Specific functions are shown in boxes. MAP4Ks, mitogen‐activated protein kinase kinase kinase kinases; NDR1/2, nuclear Dbf2‐related1/2; NF2, neurofibromin 2; GPCRs, G protein‐coupled receptors; FAK, focal adhesion kinase; MST1/2, sterility 20‐like protein kinase1/2; SAV1, Salvador 1; MOB1, MOB kinase activator 1; LATS1/2, large tumour suppressor 1/2; YAP, yes‐associated protein; TAZ, transcriptional coactivator with a PDZ‐binding motif; TEADs, TEA domain DNA‐binding family members; CTGF, connective tissue growth factor; AP‐1, activator protein 1; DR, diabetic retinopathy; PVR, proliferative vitreoretinopathy; AMD, age‐related macular degeneration; RB, retinoblastoma; UM, uveal melanoma; EMT, epithelial‐mesenchymal transition; EndMT, endothelial‐mesenchymal transition; ECM, extracellular matrix; RSLC, retinoblastoma stem‐like cells.

Publication

The Hippo signalling pathway and its impact on eye diseases. (2024) Yuxiang Du. J Cell Mol Med. 2024 Apr;28(8):e18300. Figure: F1. Homo sapiens

Disease mentions