Targeting Siglec–Sialylated MUC1 Immune Axis in Cancer
The use of small-molecule metabolic inhibitors, such as the fluorinated sialic acid analogue 3Fax-Neu5Ac, to obstruct the synthesis of sialylation pathway. As a result, the cell surface-expressed glycans are not capped with sialic acid, and their interaction with Siglecs is blocked.
Publication
Targeting Siglec–Sialylated MUC1 Immune Axis in Cancer. (2024) Ramya Ayyalasomayajula, et al. Cancers (Basel). 2024 Apr;16(7):1334. Figure: F7.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | GNE | GNE | ncbigene_symbol | GNE | 10020 |
| Homo sapiens | Primates | MNK | MNK | ncbigene_synonym | ATP7A | 538 |
| Homo sapiens | Primates | NANS | NANS | ncbigene_symbol | NANS | 54187 |
| Homo sapiens | Primates | CMP | CMP | ncbigene_synonym | MATN1 | 4146 |
| Homo sapiens | Primates | Gal | GAL | ncbigene_symbol | GAL | 51083 |
| Homo sapiens | Primates | Gal | GAL | ncbigene_synonym | GALP | 85569 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| UDP-GlcNAc | UDP-GlcNAc | uridine 5'-[3-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl) dihydrogen diphosphate] | chebi:16264 | |
| CMP | CMP | 5'-O-phosphonatocytidine | chebi:60377 | |
| Nucleus | nucleus | nucleus | chebi:33252 | |
| CMP-Sialic acid | CMP-sialic acid | cytidine 5'-(5-acetamido-3,5-dideoxy-D-glycero-beta-D-galacto-non-2-ulopyranosylonic acid monophosphate) | chebi:16556 | |
| Inhibitors | inhibitors | inhibitor | chebi:35222 | |
| GalNAc | GalNAc | N-acetyl-D-galactosamine | chebi:28037 | |
| Gal | Gal | galacto-hexose | chebi:28260 | |
| Neu5Ac | Neu5Ac | 5-acetamido-3,5-dideoxy-D-glycero-D-galacto-non-2-ulosonic acid | chebi:173082 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
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