Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis

Silent information regulator sirtuin 1 activation ameliorates lipopolysaccharide/D-galactosamine-induced acute liver failure by inhibiting p53/glutathione peroxidase 4/gasdermin D to reduce ferroptosis and pyroptosis. Silent information regulator sirtuin 1 activation inhibits p53 deacetylation, thereby inhibiting the glutathione peroxidase 4 (GPX4)/gasdermin D (GSDMD) signaling pathway and reducing inflammatory response and iron deposition. Blocking the p53/GPX4/GSDMD signaling pathway attenuates ferroptosis and pyroptosis in acute liver failure. IL: Interleukin; GPX4: Glutathione peroxidase 4; SLC7A11: Solute carrier family 7a member 11; GSDMD: Gasdermin D; SIRT1: Silent information regulator sirtuin 1; ROS: Reactive oxygen species; GSH: Glutathione; TNF-α: Tumour necrosis factor alpha.
Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis
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Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis. (2024) Xing-Nian Zhou, et al. World J Gastroenterol. 2024 Mar 21;30(11):1588-1608. Figure: F8.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates ac ADCY famplex_relations ADCY1 107
Homo sapiens Primates ac ADCY famplex_relations ADCY2 108
Homo sapiens Primates ac ADCY famplex_relations ADCY3 109
Homo sapiens Primates ac ADCY famplex_relations ADCY4 196883
Homo sapiens Primates ac ADCY famplex_relations ADCY5 111
Homo sapiens Primates ac ADCY famplex_relations ADCY6 112
Homo sapiens Primates ac ADCY famplex_relations ADCY7 113
Homo sapiens Primates ac ADCY famplex_relations ADCY8 114
Homo sapiens Primates ac ADCY famplex_relations ADCY9 115
Homo sapiens Primates ac ADCY famplex_relations ADCY10 55811
Homo sapiens Primates SIRT1 SIRT1 ncbigene_symbol SIRT1 23411
Homo sapiens Primates p53 P53 ncbigene_synonym TP53 7157
Homo sapiens Primates p53 P53 famplex_relations TP63 8626
Homo sapiens Primates p53 P53 famplex_relations TP73 7161
Homo sapiens Primates IL-6 IL-6 ncbigene_synonym IL6 3569
Homo sapiens Primates SLC7A11 SLC7A11 ncbigene_symbol SLC7A11 23657
Homo sapiens Primates GPX4 GPX4 ncbigene_symbol GPX4 2879
Homo sapiens Primates GSDMD GSDMD ncbigene_symbol GSDMD 79792
Homo sapiens Primates TNF-a TNF-A ncbigene_synonym TNF 7124
Homo sapiens Primates SLC3A2 SLC3A2 ncbigene_symbol SLC3A2 6520
Homo sapiens Primates IL-1ẞ IL1 ncbigene_synonym IL1A 3552
Homo sapiens Primates IL-1ẞ IL1 ncbigene_synonym IL1B 3553

Chemical mentions

Word Match MeSH Name ChEBI
TNF-a TNF-a chebi:197439
GSH GSH L-gamma-glutamyl-L-cysteinylglycine chebi:16856

Disease mentions

Word Match MeSH Name DOID