Therapeutic prospects of nectin-4 in cancer: applications and value
the process of Nectin-4 regulating cancer development through PI3K/AKT pathway and promoting angiogenesis after hypoxia. Nectin-4 can downregulate miR-520c-3p to activate the PI3K/AKT/NF-κB pathway, promoting the progression and metastasis; Soluble nectin-4, which is formed by the shedding of Nectin-4 extracellular domain during hypoxia, can interact with integrin-β4 on endothelial cells to promote angiogenesis. This progress is realized via the Src, PI3K, Akt, and eNOS pathways, and may be related to PI3K-Akt-mediated NO formation.
Publication
Therapeutic prospects of nectin-4 in cancer: applications and value. (2024) Kaiyue Li, et al. Front Oncol. 2024;14:1354543. Figure: F2.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | AAA- | AAA | ncbigene_synonym | APP | 351 |
| Homo sapiens | Primates | AAA- | AAA | ncbigene_synonym | AAAS | 8086 |
| Homo sapiens | Primates | AAA- | AAA | ncbigene_synonym | AAA1 | 100329167 |
| Homo sapiens | Primates | AKT1 | AKT1 | ncbigene_symbol | AKT1 | 207 |
| Homo sapiens | Primates | P65 | P65 | ncbigene_synonym | RELA | 5970 |
| Homo sapiens | Primates | P65 | P65 | ncbigene_synonym | SYT1 | 6857 |
| Homo sapiens | Primates | P65 | P65 | ncbigene_synonym | GORASP1 | 64689 |
| Homo sapiens | Primates | P65 | P65 | ncbigene_synonym | WNK1 | 65125 |
| Homo sapiens | Primates | HIF-1a | HIF-1A | ncbigene_synonym | HIF1A | 3091 |
| Homo sapiens | Primates | ADAM-17↑ | ADAM17 | ncbigene_symbol | ADAM17 | 6868 |
| Homo sapiens | Primates | INOS | INOS | ncbigene_synonym | NOS2 | 4843 |
| Homo sapiens | Primates | INOS | INOS | ncbigene_synonym | ISYNA1 | 51477 |
| Homo sapiens | Primates | eNOS | ENOS | ncbigene_synonym | NOS3 | 4846 |
| Homo sapiens | Primates | eNOS | ENOS | ncbigene_synonym | ENO4 | 387712 |
| Homo sapiens | Primates | AKT | AKT | famplex_relations | AKT2 | 208 |
| Homo sapiens | Primates | AKT | AKT | famplex_relations | AKT3 | 10000 |
| Homo sapiens | Primates | Zo-1,Vimentin | ZO-1 | ncbigene_synonym | TJP1 | 7082 |
| Homo sapiens | Primates | Nectin-4 | NECTIN-4 | ncbigene_synonym | NECTIN4 | 81607 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CA | 5290 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CB | 5291 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CD | 5293 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CG | 5294 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R3 | 8503 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R4 | 30849 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R5 | 23533 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R6 | 146850 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R1 | 5295 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R2 | 5296 |
| Homo sapiens | Primates | Src | SRC | ncbigene_symbol | SRC | 6714 |
| Homo sapiens | Primates | Src | SRC | famplex_relations | FGR | 2268 |
| Homo sapiens | Primates | Src | SRC | famplex_relations | FYN | 2534 |
| Homo sapiens | Primates | Src | SRC | famplex_relations | YES1 | 7525 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|---|---|---|---|
| Cancer | cancer | cancer | DOID:162 |