Various intracellular signaling molecules and pathways involved in HSCR

Various intracellular signaling molecules and pathways involved in HSCR. Including receptors like RET, ENDRB; signaling proteins such as AKT, ERK; and transcription factors like SOX10, PHOX2B. Neurotrophic factors such as GDNF, ARTN, PSPN, and NTF3 interact with corresponding receptors GFRα1-4 and NTRK. Additionally, pathways like the NOTCH signaling pathway, Sonic Hedgehog (SHH) pathway, as well as other molecules (such as SEMA3C and SEMA3D), play significant roles in enteric neurons
Various intracellular signaling molecules and pathways involved in HSCR
Download JPG
View figure at PMC Read paper at PMC
PMC

Publication

The roles of non-coding RNAs in Hirschsprung's disease (2024) Yang Yang, et al. Noncoding RNA Res. 2024 Sep;9(3). Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates RET RET ncbigene_symbol RET 5979
Homo sapiens Primates GDNF GDNF ncbigene_symbol GDNF 2668
Homo sapiens Primates GFRal GFRAL ncbigene_symbol GFRAL 389400
Homo sapiens Primates NRTN NRTN ncbigene_symbol NRTN 4902
Homo sapiens Primates ARTN ARTN ncbigene_symbol ARTN 9048
Homo sapiens Primates PSPN PSPN ncbigene_symbol PSPN 5623
Homo sapiens Primates NTF3 NTF3 ncbigene_symbol NTF3 4908
Homo sapiens Primates ERK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates ERK ERK ncbigene_synonym MAPK1 5594
Homo sapiens Primates ERK ERK famplex_relations MAPK3 5595
Homo sapiens Primates NTRK NTRK famplex_relations NTRK1 4914
Homo sapiens Primates NTRK NTRK famplex_relations NTRK2 4915
Homo sapiens Primates NTRK NTRK famplex_relations NTRK3 4916
Homo sapiens Primates SOX10 SOX10 ncbigene_symbol SOX10 6663
Homo sapiens Primates PHOX2B PHOX2B ncbigene_symbol PHOX2B 8929
Homo sapiens Primates NOTCH NOTCH famplex_relations NOTCH1 4851
Homo sapiens Primates NOTCH NOTCH famplex_relations NOTCH2 4853
Homo sapiens Primates NOTCH NOTCH famplex_relations NOTCH3 4854
Homo sapiens Primates NOTCH NOTCH famplex_relations NOTCH4 4855
Homo sapiens Primates ZEB2 ZEB2 ncbigene_symbol ZEB2 9839
Homo sapiens Primates SHH SHH ncbigene_symbol SHH 6469
Homo sapiens Primates IHH IHH ncbigene_symbol IHH 3549
Homo sapiens Primates PROKR1 PROKR1 ncbigene_symbol PROKR1 10887
Homo sapiens Primates PROKR2 PROKR2 ncbigene_symbol PROKR2 128674
Homo sapiens Primates ERBB ERBB ncbigene_synonym EGFR 1956
Homo sapiens Primates ERBB ERBB famplex_relations ERBB2 2064
Homo sapiens Primates ERBB ERBB famplex_relations ERBB3 2065
Homo sapiens Primates ERBB ERBB famplex_relations ERBB4 2066
Homo sapiens Primates PROK2 PROK2 ncbigene_symbol PROK2 60675
Homo sapiens Primates NRG1 NRG1 ncbigene_symbol NRG1 3084
Homo sapiens Primates KIFBP KIFBP ncbigene_symbol KIFBP 26128
Homo sapiens Primates SCG10 SCG10 ncbigene_synonym STMN2 11075
Homo sapiens Primates SEMA3D SEMA3D ncbigene_symbol SEMA3D 223117
Homo sapiens Primates SEMA3C SEMA3C ncbigene_symbol SEMA3C 10512

Chemical mentions

Word Match MeSH Name ChEBI
SHH SHH N-hydroxy-N'-phenyloctanediamide chebi:45716
NRG1 NRG1 chebi:231555

Disease mentions

Word Match MeSH Name DOID