Ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer

PI3K/Akt pathway-mediated GPX4 and SLC7A11 regulation inhibits ferroptosis
Ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer

Publication

Regulation of ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer (2024) Hua Su, et al. Front Cell Dev Biol. 2024;12(NA). Figure: F4.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates SLC7A11- SLC7A11 ncbigene_symbol SLC7A11 23657
Homo sapiens Primates ABCD1 ABCD1 ncbigene_symbol ABCD1 215
Homo sapiens Primates ABCD1 ABCD1 ncbigene_synonym CCL22 6367
Homo sapiens Primates ABCC5 ABCC5 ncbigene_symbol ABCC5 10057
Homo sapiens Primates CCT3 CCT3 ncbigene_symbol CCT3 7203
Homo sapiens Primates P110 P110 ncbigene_synonym CUX1 1523
Homo sapiens Primates P110 P110 ncbigene_synonym SART3 9733
Homo sapiens Primates HIF-1a HIF-1A ncbigene_synonym HIF1A 3091
Homo sapiens Primates STAT3 STAT3 ncbigene_symbol STAT3 6774
Homo sapiens Primates ARG2 ARG2 ncbigene_symbol ARG2 384
Homo sapiens Primates mTORC1 MTORC1 famplex_relations MTOR 2475
Homo sapiens Primates mTORC1 MTORC1 famplex_relations RPTOR 57521
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates CKB CKB ncbigene_symbol CKB 1152
Homo sapiens Primates CKB CKB ncbigene_synonym CHKB 1120
Homo sapiens Primates TIMP1 TIMP1 ncbigene_symbol TIMP1 7076
Homo sapiens Primates GPX4 GPX4 ncbigene_symbol GPX4 2879
Homo sapiens Primates GSK-3ẞ GSK3 famplex_relations GSK3A 2931
Homo sapiens Primates GSK-3ẞ GSK3 famplex_relations GSK3B 2932
Homo sapiens Primates MGST1 MGST1 ncbigene_symbol MGST1 4257

Chemical mentions

Word Match MeSH Name ChEBI
Glu Glu 2-aminopentanedioic acid chebi:18237
Cys Cys cysteine chebi:15356
Hormones hormones chebi:24621
Pas PAS 4-amino-2-hydroxybenzoic acid chebi:27565
GSH GSH L-gamma-glutamyl-L-cysteinylglycine chebi:16856

Disease mentions

Word Match MeSH Name DOID