Depiction of Wnt Signaling Dysregulation in TNBC Cells When Compared to Healthy, Noncancerous Cells
In healthy noncancerous cells, a destruction complex comprised of APC, Axin, GSK-3β, and CK1α degrades β-catenin in the cytoplasm via ubiquitin-mediated proteolysis. This prevents β-catenin movement to the nucleus, therefore leaving downstream Wnt genes off. In TNBC cells, extracellular Wnt ligands bind to overexpressed Frizzled7 (FZD7) receptors, which recruits disheveled to the receptor to inhibit the destruction complex. This allows β-catenin to accumulate in the cytoplasm before translocating to the nucleus to activate the transcription of Wnt target genes that promote oncogenesis. Adapted from “Wnt Signaling Pathway Activation and Inhibition”, by BioRender.com (2023). Retrieved from https://app.biorender.com/biorender-templates
Publication
FZD7-Targeted Nanoparticles to Enhance Doxorubicin Treatment of Triple-Negative Breast Cancer (2024) Elise C. Hoover, et al. ACS Omega. 2024 Mar 26;9(12). Scheme: S1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT1 | 7471 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT2 | 7472 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT2B | 7482 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT3 | 7473 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT3A | 89780 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT4 | 54361 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT6 | 7475 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT7A | 7476 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT7B | 7477 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT8A | 7478 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT8B | 7479 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT9A | 7483 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT9B | 7484 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT10A | 80326 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT10B | 7480 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT11 | 7481 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT16 | 51384 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT5A | 7474 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT5B | 81029 |
| Homo sapiens | Primates | LRP | LRP | ncbigene_synonym | RPSA | 3921 |
| Homo sapiens | Primates | LRP | LRP | ncbigene_synonym | LRP1 | 4035 |
| Homo sapiens | Primates | LRP | LRP | ncbigene_synonym | PTPRA | 5786 |
| Homo sapiens | Primates | LRP | LRP | ncbigene_synonym | MVP | 9961 |
| Homo sapiens | Primates | LRP5/6 | LRP5 | ncbigene_symbol | LRP5 | 4041 |
| Homo sapiens | Primates | LRP5/6 | LRP6 | ncbigene_symbol | LRP6 | 4040 |
| Homo sapiens | Primates | APC | APC | ncbigene_symbol | APC | 324 |
| Homo sapiens | Primates | APC | APC | ncbigene_synonym | PROC | 5624 |
| Homo sapiens | Primates | Axin | AXIN | ncbigene_synonym | AXIN1 | 8312 |
| Homo sapiens | Primates | Axin | AXIN | famplex_relations | AXIN2 | 8313 |
| Homo sapiens | Primates | GSK-3ẞ | GSK3 | famplex_relations | GSK3A | 2931 |
| Homo sapiens | Primates | GSK-3ẞ | GSK3 | famplex_relations | GSK3B | 2932 |
| Homo sapiens | Primates | B-Catenin | CTNNB1 | ncbigene_symbol | CTNNB1 | 1499 |
| Homo sapiens | Primates | CK1a | CK1A | ncbigene_synonym | CSNK1A1 | 1452 |
| Homo sapiens | Primates | Frizzled7 | FZD7 | ncbigene_symbol | FZD7 | 8324 |
| Homo sapiens | Primates | TCF/LEF | TCF | ncbigene_synonym | HNF4A | 3172 |
| Homo sapiens | Primates | BCL9 | BCL9 | ncbigene_symbol | BCL9 | 607 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|