Therapeutic tyrosine kinase inhibitors and anti-EGFR monoclonal antibodies in glioblastoma anti-EGFR mAbs bind the EGFR extracellular domain, preventing EGFR dimerization and subsequent activation

Therapeutic tyrosine kinase inhibitors and anti-EGFR monoclonal antibodies in glioblastoma anti-EGFR mAbs bind the EGFR extracellular domain, preventing EGFR dimerization and subsequent activation. Tyrosine kinase inhibitors (TKIs) target the intracellular TK domain, blocking subsequent receptor tyrosine kinase pathways (RTKs)
Therapeutic tyrosine kinase inhibitors and anti-EGFR monoclonal antibodies in glioblastoma anti-EGFR mAbs bind the EGFR extracellular domain, preventing EGFR dimerization and subsequent activation
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Publication

vNARs as Neutralizing Intracellular Therapeutic Agents: Glioblastoma as a Target (2024) Alejandro Manzanares-Guzmán, et al. Antibodies (Basel). 2024 Mar;13(1). Figure: F3.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates EGFR EGFR ncbigene_symbol EGFR 1956
Homo sapiens Primates EPR, EPR ncbigene_synonym EREG 2069
Homo sapiens Primates BTC BTC ncbigene_symbol BTC 685
Homo sapiens Primates TGF-a, TGFA ncbigene_symbol TGFA 7039
Homo sapiens Primates -EGF, EGF ncbigene_symbol EGF 1950
Homo sapiens Primates (TK) TK famplex_relations TK1 7083
Homo sapiens Primates (TK) TK famplex_relations TK2 7084
Homo sapiens Primates Ras RAS famplex_relations KRAS 3845
Homo sapiens Primates Ras RAS famplex_relations HRAS 3265
Homo sapiens Primates Ras RAS famplex_relations NRAS 4893
Homo sapiens Primates Sos SOS ncbigene_synonym XYLT2 64132
Homo sapiens Primates Sos SOS famplex_relations SOS1 6654
Homo sapiens Primates Sos SOS famplex_relations SOS2 6655
Homo sapiens Primates GRB2 GRB2 ncbigene_symbol GRB2 2885
Homo sapiens Primates GTP GTP ncbigene_synonym MTG1 92170
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates JAK JAK famplex_relations JAK1 3716
Homo sapiens Primates JAK JAK famplex_relations JAK2 3717
Homo sapiens Primates JAK JAK famplex_relations JAK3 3718
Homo sapiens Primates JAK JAK famplex_relations TYK2 7297
Homo sapiens Primates PDK1 PDK1 ncbigene_symbol PDK1 5163
Homo sapiens Primates PDK1 PDK1 ncbigene_synonym PDPK1 5170
Homo sapiens Primates STAT3 STAT3 ncbigene_symbol STAT3 6774
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates TSC1/2 TSC1 ncbigene_symbol TSC1 7248
Homo sapiens Primates TSC1/2 TSC1 ncbigene_synonym CCL26 10344
Homo sapiens Primates TSC1/2 TSC2 ncbigene_symbol TSC2 7249
Homo sapiens Primates Rheb RHEB ncbigene_symbol RHEB 6009
Homo sapiens Primates Rheb RHEB ncbigene_synonym RHEBP1 6008
Homo sapiens Primates mTORC1 MTORC1 famplex_relations MTOR 2475
Homo sapiens Primates mTORC1 MTORC1 famplex_relations RPTOR 57521

Chemical mentions

Word Match MeSH Name ChEBI
Tyrosine kinase inhibitors tyrosine kinase inhibitors chebi:38637
Erlotinib erlotinib N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine chebi:114785
Gefitinib gefitinib N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine chebi:49668
Dacomitinib dacomitinib (2E)-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-(piperidin-1-yl)but-2-enamide chebi:132268
Afatinib afatinib (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide chebi:61390
Neratinib neratinib (2E)-N-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide chebi:61397
Ras RAS (1R)-N-(prop-2-yn-1-yl)indan-1-amine chebi:63620
GDP GDP 5'-O-[(phosphonatooxy)phosphinato]guanosine chebi:58189
GTP GTP GTP chebi:37565
Ras RAS (1R)-N-(prop-2-yn-1-yl)indan-1-amine chebi:63620
PIP3 PIP3 1-O-(3-sn-phosphatidyl)-1D-myo-inositol 3,4,5-tris(dihydrogen phosphate) chebi:16618
GTP GTP GTP chebi:37565
Nucleus nucleus nucleus chebi:33252

Disease mentions

Word Match MeSH Name DOID
Glioblastoma glioblastoma glioblastoma DOID:3068