Schematic illustrating the proposed mechanism by which the PERK pathway modulates autophagy during RACK1‐mediated neuroprotection after TBI

Schematic illustrating the proposed mechanism by which the PERK pathway modulates autophagy during RACK1‐mediated neuroprotection after TBI. TBI upregulates RACK1, which interacts with PERK and activates the PERK/eIF2α/ATF4 signaling pathway, thereby promoting autophagy induction by increasing the transcription of multiple autophagy‐related genes, including LC3, Atg5, and Beclin1. Thus, RACK1 upregulation alleviates neuronal apoptosis after TBI
Schematic illustrating the proposed mechanism by which the PERK pathway modulates autophagy during RACK1‐mediated neuroprotection after TBI
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Publication

RACK1 promotes autophagy via the PERK signaling pathway to protect against traumatic brain injury in rats (2024) Haibo Ni, et al. CNS Neurosci Ther. 2024 Mar;30(3). Figure: F8.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Caenorhabditis elegans Invertebrates elF2a EIF2A ncbigene_symbol eif-2alpha 171769
Caenorhabditis elegans Invertebrates elF2a EIF2A ncbigene_symbol eif-2A 174606
Caenorhabditis elegans Invertebrates ATF4 ATF4 ncbigene_symbol atf-4 181576
Caenorhabditis elegans Invertebrates RACK1 RACK1 ncbigene_symbol rack-1 177895
Caenorhabditis elegans Invertebrates Atg5 ATG5 ncbigene_symbol atg-5 171735
Homo sapiens Primates PERK PERK ncbigene_synonym EIF2AK3 9451
Homo sapiens Primates elF2a EIF2A ncbigene_symbol EIF2A 83939
Homo sapiens Primates elF2a EIF2A ncbigene_synonym EIF2S1 1965
Homo sapiens Primates ATF4 ATF4 ncbigene_symbol ATF4 468
Homo sapiens Primates RACK1 RACK1 ncbigene_symbol RACK1 10399
Homo sapiens Primates LC3 LC3 ncbigene_synonym MAP1LC3A 84557
Homo sapiens Primates Beclin1 BECLIN1 ncbigene_synonym BECN1 8678
Homo sapiens Primates Atg5 ATG5 ncbigene_symbol ATG5 9474

Chemical mentions

Word Match MeSH Name ChEBI
PERK PERK tetrachloroethene chebi:17300
PERK PERK tetrachloroethene chebi:17300
Nucleus nucleus nucleus chebi:33252

Disease mentions

Word Match MeSH Name DOID