Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity

Comparison of TCA cycle between ad libitum feeding and 16 h fasting(A) Metabolic reactions, molecules, and regulations in TCA cycle (mmu00020) extracted from the differential regulatory trans-omic network at ad libitum feeding (top left) and 16 h fasting (bottom left), and the numbers of differentially expressed molecules (nodes) and differential regulations (edges) in TCA cycle at ad libitum feeding (top right) and 16 h fasting (bottom right).34 Other descriptions are the same as Figure 6B.(B) Summary of the opposite changes in the metabolites and allosteric regulations between ad libitum feeding (left) and 16 h fasting (right).34 Metabolic pathway names related to metabolites are in parentheses. Arrow, allosteric regulation. Yellow area, the metabolic pathways regulated by allosteric regulators. See also Figures S12–S18.Red, increased molecules or activating regulations in ob/ob mice; blue, decreased molecules or inhibiting regulations in ob/ob mice; magenta, both activated and inhibited metabolic reactions in ob/ob mice; gray, unchanged molecules between WT and ob/ob mice

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Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity (2024) Yunfan Bai, et al. iScience. 2024 Mar 15;27(3). Figure: F7. Homo sapiens

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