Underlying mechanism of obesity and hyperuricemia

The underlying mechanism of obesity and hyperuricemia. (A) Protein-protein interaction (PPI) network obtained from STRING database and constructed by Cytoscape. Each node size and color depth are proportional to their node degree. Edge width is proportional to the edge betweenness. (B) Grouping of KEGG enrichment analysis of the 235 intersected targets of obesity leading to hyperuricemia. Functionally related groups partially overlap. KEGG pathway is represented as a node. The nodes of a group are labeled in the same color. Two groups share the nodes with two colors
Underlying mechanism of obesity and hyperuricemia
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Publication

Associations between obesity and hyperuricemia combing mendelian randomization with network pharmacology (2024) Kailai Panlu, et al. Heliyon. 2024 Mar 30;10(6). Figure: F5.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates TNF TNF ncbigene_symbol TNF 7124
Homo sapiens Primates CAM CAM ncbigene_synonym CALM1 801
Homo sapiens Primates CAM CAM ncbigene_synonym CALM2 805
Homo sapiens Primates CAM CAM ncbigene_synonym CALM3 808
Homo sapiens Primates CAM CAM ncbigene_synonym KRIT1 889
Homo sapiens Primates CAM CAM ncbigene_synonym CAMKMT 79823
Homo sapiens Primates POMC POMC ncbigene_symbol POMC 5443
Homo sapiens Primates APOB APOB ncbigene_symbol APOB 338
Homo sapiens Primates ADIPOQ ADIPOQ ncbigene_symbol ADIPOQ 9370
Homo sapiens Primates APOAL APOAL ncbigene_synonym LPAL2 80350
Homo sapiens Primates GAPDH GAPDH ncbigene_symbol GAPDH 2597
Homo sapiens Primates GAPDH GAPDH ncbigene_synonym GAPDHP44 100240709
Homo sapiens Primates CCL2 CCL2 ncbigene_symbol CCL2 6347
Homo sapiens Primates CDM CDM ncbigene_synonym CALD1 800
Homo sapiens Primates CDM CDM ncbigene_synonym BCAP31 10134
Homo sapiens Primates TP53 TP53 ncbigene_symbol TP53 7157
Homo sapiens Primates CRP CRP ncbigene_symbol CRP 1401
Homo sapiens Primates CRP CRP ncbigene_synonym CSRP1 1465
Homo sapiens Primates CRP CRP ncbigene_synonym PPIAP10 140913
Homo sapiens Primates IL6 IL6 ncbigene_symbol IL6 3569
Homo sapiens Primates JUN JUN ncbigene_symbol JUN 3725
Homo sapiens Primates JUN JUN famplex_relations JUNB 3726
Homo sapiens Primates JUN JUN famplex_relations JUND 3727
Homo sapiens Primates INS INS ncbigene_symbol INS 3630
Homo sapiens Primates REN REN ncbigene_symbol REN 5972
Homo sapiens Primates REN REN ncbigene_synonym KCTD11 147040
Homo sapiens Primates APOE APOE ncbigene_symbol APOE 348
Homo sapiens Primates ALB ALB ncbigene_symbol ALB 213
Homo sapiens Primates ALB ALB ncbigene_synonym FBF1 85302
Homo sapiens Primates CAT CAT ncbigene_symbol CAT 847
Homo sapiens Primates CAT CAT ncbigene_synonym CRAT 1384
Homo sapiens Primates CAT CAT ncbigene_synonym GLYAT 10249
Homo sapiens Primates LEP LEP ncbigene_symbol LEP 3952
Homo sapiens Primates ACE ACE ncbigene_symbol ACE 1636
Homo sapiens Primates TRAN TRAN ncbigene_synonym TRA-TGC7-1 7154
Homo sapiens Primates GPT GPT ncbigene_symbol GPT 2875
Homo sapiens Primates GPT GPT ncbigene_synonym DPAGT1 1798
Homo sapiens Primates CASP CASP ncbigene_synonym CUX1 1523
Homo sapiens Primates CASP CASP ncbigene_synonym CYTIP 9595
Homo sapiens Primates CASP CASP ncbigene_synonym CRTAP 10491
Homo sapiens Primates IL-17 IL-17 ncbigene_synonym IL17A 3605
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA1 5562
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA2 5563
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAB1 5564
Homo sapiens Primates AMPK AMPK famplex_relations PRKAB2 5565
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG1 5571
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG2 51422
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG3 53632
Homo sapiens Primates HIF-1 HIF-1 ncbigene_synonym SETD2 29072
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates PI3K/Aktsignaling PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K/Aktsignaling PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K/Aktsignaling PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K/Aktsignaling PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K/Aktsignaling PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K/Aktsignaling PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K/Aktsignaling PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K/Aktsignaling PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K/Aktsignaling PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K/Aktsignaling PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates PPARA PPARA ncbigene_symbol PPARA 5465

Chemical mentions

Word Match MeSH Name ChEBI
CRP cRP cyclo(L-arginyl-L-prolyl) chebi:231491
CAT cat rac-2-(methylamino)-1-phenylpropan-1-one chebi:149681
Cholesterol cholesterol cholesterol chebi:16113

Disease mentions

Word Match MeSH Name DOID
atherosclerosis atherosclerosis atherosclerosis DOID:1936