Quantitative proteomics reveals the protective effects of Yinchenzhufu decoction against cholestatic liver fibrosis in mice by inhibiting the PDGFRB/PI3K/AKT pathway

PPI network analysis of potential interacting proteins corresponded to different clusters in the above biological processes and pathways
Quantitative proteomics reveals the protective effects of Yinchenzhufu decoction against cholestatic liver fibrosis in mice by inhibiting the PDGFRB/PI3K/AKT pathway
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Quantitative proteomics reveals the protective effects of Yinchenzhufu decoction against cholestatic liver fibrosis in mice by inhibiting the PDGFRβ/PI3K/AKT pathway (2024) Qian Meng, et al. Front Pharmacol. 2024;15(NA). Figure: F5.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates S100 S100 ncbigene_synonym S100A1 6271
Homo sapiens Primates S100 S100 ncbigene_synonym S100B 6285
Homo sapiens Primates S100 S100 famplex_relations S100G 795
Homo sapiens Primates S100 S100 famplex_relations S100P 6286
Homo sapiens Primates S100 S100 famplex_relations S100Z 170591
Homo sapiens Primates S100 S100 famplex_relations HRNR 388697
Homo sapiens Primates S100 S100 famplex_relations S100A10 6281
Homo sapiens Primates S100 S100 famplex_relations S100A11 6282
Homo sapiens Primates S100 S100 famplex_relations S100A12 6283
Homo sapiens Primates S100 S100 famplex_relations S100A13 6284
Homo sapiens Primates S100 S100 famplex_relations S100A14 57402
Homo sapiens Primates S100 S100 famplex_relations S100A16 140576
Homo sapiens Primates S100 S100 famplex_relations S100A2 6273
Homo sapiens Primates S100 S100 famplex_relations S100A3 6274
Homo sapiens Primates S100 S100 famplex_relations S100A4 6275
Homo sapiens Primates S100 S100 famplex_relations S100A5 6276
Homo sapiens Primates S100 S100 famplex_relations S100A6 6277
Homo sapiens Primates S100 S100 famplex_relations S100A7 6278
Homo sapiens Primates S100 S100 famplex_relations S100A7A 338324
Homo sapiens Primates S100 S100 famplex_relations S100A8 6279
Homo sapiens Primates S100 S100 famplex_relations S100A9 6280
Homo sapiens Primates S100 S100 famplex_relations TCHHL1 126637
Homo sapiens Primates Hal HAL ncbigene_symbol HAL 3034
Homo sapiens Primates Hal HAI ncbigene_synonym SPINT1 6692
Homo sapiens Primates Hal HAI ncbigene_synonym ST14 6768
Homo sapiens Primates mb MB ncbigene_symbol MB 4151
Homo sapiens Primates Bn1 BN1 ncbigene_synonym BNC1 646
Homo sapiens Primates Bn1 BN1 ncbigene_synonym CCR6 1235
Homo sapiens Primates Cam CAM ncbigene_synonym CALM1 801
Homo sapiens Primates Cam CAM ncbigene_synonym CALM2 805
Homo sapiens Primates Cam CAM ncbigene_synonym CALM3 808
Homo sapiens Primates Cam CAM ncbigene_synonym KRIT1 889
Homo sapiens Primates Cam CAM ncbigene_synonym CAMKMT 79823
Homo sapiens Primates Mpg MPG ncbigene_symbol MPG 4350
Homo sapiens Primates Zbp1 ZBP1 ncbigene_symbol ZBP1 81030
Homo sapiens Primates Zbp1 ZBP1 ncbigene_synonym IGF2BP1 10642
Homo sapiens Primates Gbp2 GBP2 ncbigene_symbol GBP2 2634
Homo sapiens Primates Car CAR ncbigene_synonym CASR 846
Homo sapiens Primates Car CAR ncbigene_synonym CXADR 1525
Homo sapiens Primates Car CAR ncbigene_synonym PRKAR1A 5573
Homo sapiens Primates Car CAR ncbigene_synonym SPG7 6687
Homo sapiens Primates Car CAR ncbigene_synonym NR1I3 9970
Homo sapiens Primates Car CAR ncbigene_synonym TRIM13 10206
Homo sapiens Primates Car CAR ncbigene_synonym CXADRP1 653108
Homo sapiens Primates Cdk5 CDK5 ncbigene_symbol CDK5 1020
Homo sapiens Primates Sumo2 SUMO2 ncbigene_symbol SUMO2 6613
Homo sapiens Primates Hgs HGS ncbigene_symbol HGS 9146
Homo sapiens Primates Itgam ITGAM ncbigene_symbol ITGAM 3684
Homo sapiens Primates Ube2b UBE2B ncbigene_symbol UBE2B 7320
Homo sapiens Primates Rock2 ROCK2 ncbigene_symbol ROCK2 9475
Homo sapiens Primates ich ICH ncbigene_synonym COL4A2 1284
Homo sapiens Primates Serpinb SERPINB famplex_relations SERPINB1 1992
Homo sapiens Primates Serpinb SERPINB famplex_relations SERPINB2 5055
Homo sapiens Primates Serpinb SERPINB famplex_relations SERPINB3 6317
Homo sapiens Primates Serpinb SERPINB famplex_relations SERPINB4 6318
Homo sapiens Primates Serpinb SERPINB famplex_relations SERPINB5 5268
Homo sapiens Primates Serpinb SERPINB famplex_relations SERPINB6 5269
Homo sapiens Primates Serpinb SERPINB famplex_relations SERPINB7 8710
Homo sapiens Primates Serpinb SERPINB famplex_relations SERPINB8 5271
Homo sapiens Primates Serpinb SERPINB famplex_relations SERPINB9 5272
Homo sapiens Primates Serpinb SERPINB famplex_relations SERPINB10 5273
Homo sapiens Primates Serpinb SERPINB famplex_relations SERPINB11 89778
Homo sapiens Primates Serpinb SERPINB famplex_relations SERPINB12 89777
Homo sapiens Primates Serpinb SERPINB famplex_relations SERPINB13 5275
Homo sapiens Primates Eng ENG ncbigene_symbol ENG 2022
Homo sapiens Primates Txnip TXNIP ncbigene_symbol TXNIP 10628
Homo sapiens Primates Gmfb GMFB ncbigene_symbol GMFB 2764
Homo sapiens Primates Fabp7 FABP7 ncbigene_symbol FABP7 2173
Homo sapiens Primates Pdgfrb PDGFRB ncbigene_symbol PDGFRB 5159
Homo sapiens Primates Snca SNCA ncbigene_symbol SNCA 6622
Homo sapiens Primates lgb! IGB ncbigene_synonym CD79B 974
Homo sapiens Primates Saa4 SAA4 ncbigene_symbol SAA4 6291
Homo sapiens Primates Mapk1 MAPK1 ncbigene_symbol MAPK1 5594
Homo sapiens Primates Scar2 SCAR2 ncbigene_synonym WASF2 10163
Homo sapiens Primates Scar2 SCAR2 ncbigene_synonym PMPCA 23203
Homo sapiens Primates Nectin2 NECTIN2 ncbigene_symbol NECTIN2 5819
Homo sapiens Primates Gpnmb GPNMB ncbigene_symbol GPNMB 10457
Homo sapiens Primates Pak2 PAK2 ncbigene_symbol PAK2 5062
Homo sapiens Primates Pak2 PAK2 ncbigene_synonym PKN2 5586
Homo sapiens Primates Apoa APOA ncbigene_synonym LPA 4018
Homo sapiens Primates Apoa APOA famplex_relations APOA1 335
Homo sapiens Primates Apoa APOA famplex_relations APOA2 336
Homo sapiens Primates Apoa APOA famplex_relations APOA4 337
Homo sapiens Primates Apoa APOA famplex_relations APOA5 116519
Homo sapiens Primates Mogat2 MOGAT2 ncbigene_symbol MOGAT2 80168
Homo sapiens Primates Scd SCD ncbigene_symbol SCD 6319
Homo sapiens Primates Scd SCD famplex_relations SCD5 79966
Homo sapiens Primates Asns ASNS ncbigene_symbol ASNS 440
Homo sapiens Primates Got GOT famplex_relations GOT1 2805
Homo sapiens Primates Got GOT famplex_relations GOT2 2806
Homo sapiens Primates Nup58 NUP58 ncbigene_symbol NUP58 9818
Homo sapiens Primates Sdc4 SDC4 ncbigene_symbol SDC4 6385
Homo sapiens Primates Acta ACTA ncbigene_synonym ACTA1 58
Homo sapiens Primates Scal SCAI ncbigene_symbol SCAI 286205
Homo sapiens Primates Tpm2 TPM2 ncbigene_symbol TPM2 7169
Homo sapiens Primates sch SCH ncbigene_synonym NF2 4771
Homo sapiens Primates Gtf2b GTF2B ncbigene_symbol GTF2B 2959
Homo sapiens Primates Cyp7b1 CYP7B1 ncbigene_symbol CYP7B1 9420
Homo sapiens Primates ars ARS ncbigene_synonym RIEG2 6012
Homo sapiens Primates ars ARS ncbigene_synonym DCPS 28960
Homo sapiens Primates ars ARS ncbigene_synonym SLURP1 57152
Homo sapiens Primates Stx2 STX2 ncbigene_symbol STX2 2054
Homo sapiens Primates Cad CAD ncbigene_symbol CAD 790
Homo sapiens Primates Cad CAD ncbigene_synonym DFFB 1677
Homo sapiens Primates Cad CAD ncbigene_synonym ACOD1 730249
Homo sapiens Primates Adss1 ADSS1 ncbigene_symbol ADSS1 122622
Homo sapiens Primates Ddx47 DDX47 ncbigene_symbol DDX47 51202
Homo sapiens Primates Srd5a1 SRD5A1 ncbigene_symbol SRD5A1 6715
Homo sapiens Primates Nop NOP ncbigene_synonym OPRL1 4987
Homo sapiens Primates Nop NOP ncbigene_synonym PNOC 5368
Homo sapiens Primates Nop NOP ncbigene_synonym NOL3 8996
Homo sapiens Primates Hsd3b2 HSD3B2 ncbigene_symbol HSD3B2 3284
Homo sapiens Primates Rtca RTCA ncbigene_symbol RTCA 8634
Homo sapiens Primates tRNA TRNA ncbigene_symbol TRNA 4553
Homo sapiens Primates mox1 MOX1 ncbigene_synonym MEOX1 4222
Homo sapiens Primates mox1 MOX1 ncbigene_synonym CD200 4345
Homo sapiens Primates mox1 MOX1 ncbigene_synonym NOX1 27035

Chemical mentions

Word Match MeSH Name ChEBI
Ten TEN pentaerythritol tetranitrate chebi:25879
Nop NOP chebi:7440

Disease mentions

Word Match MeSH Name DOID