Platycodon D protects human nasal epithelial cells from pyroptosis through the Nrf2/HO-1/ROS signaling cascade in chronic rhinosinusitis
PLD improves mitochondrial damage by activating the Nrf2/HO-1 antioxidant signaling pathway, reducing ROS production, and inhibiting the activation of NLRP3 inflammasome, thereby inhibiting pyroptosis and the inflammatory damage in HNEpCs of patients with CRS
Publication
Platycodon D protects human nasal epithelial cells from pyroptosis through the Nrf2/HO-1/ROS signaling cascade in chronic rhinosinusitis (2024) Ruizhi Wang, et al. Chin Med. 2024;19(NA). Figure: F9.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | A.DC. | ADC | ncbigene_synonym | AZIN2 | 113451 |
| Homo sapiens | Primates | A.DC. | ADC | ncbigene_synonym | GADL1 | 339896 |
| Homo sapiens | Primates | HO-1 | HO-1 | ncbigene_synonym | HMOX1 | 3162 |
| Homo sapiens | Primates | Keap-1 | KEAP1 | ncbigene_symbol | KEAP1 | 9817 |
| Homo sapiens | Primates | GSDMD | GSDMD | ncbigene_symbol | GSDMD | 79792 |
| Homo sapiens | Primates | IL-1ẞ | IL1 | ncbigene_synonym | IL1A | 3552 |
| Homo sapiens | Primates | IL-1ẞ | IL1 | ncbigene_synonym | IL1B | 3553 |
| Homo sapiens | Primates | NLRP3 | NLRP3 | ncbigene_symbol | NLRP3 | 114548 |
| Homo sapiens | Primates | ASC | ASC | ncbigene_synonym | STS | 412 |
| Homo sapiens | Primates | ASC | ASC | ncbigene_synonym | PYCARD | 29108 |
| Homo sapiens | Primates | p20 | P20 | ncbigene_synonym | TPPP3 | 51673 |
| Homo sapiens | Primates | p20 | P20 | ncbigene_synonym | H3P14 | 107986209 |
| Homo sapiens | Primates | IL-18 | IL-18 | ncbigene_synonym | IL18 | 3606 |
| Homo sapiens | Primates | p10 | P10 | ncbigene_synonym | S100A10 | 6281 |
| Homo sapiens | Primates | p10 | P10 | ncbigene_synonym | EXOSC3 | 51010 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| ROS | ROS | chebi:26523 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|