Illustration of the Rel/NFKB pathway

Illustration of the Rel/NF-κB pathway. In response to stimuli such as tumour-necrosis factor-α (TNF-α), CD40 ligand (CD40L), interleukin-1 (IL-1) or lipopolysaccharide (LPS), the IKKβ subunit is activated, and phosphorylates the IκB proteins (bound to the NF-κB heterodimers) at two conserved serines. This phosphorylation event triggers the ubiquitin-dependent degradation of IκB by the 26S proteasome, resulting in the nuclear translocation of RelA – p50 (or c-Rel – p50) heterodimers and transcriptional activation of target genes [48].
Illustration of the Rel/NFKB pathway
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Publication

Rel/Nuclear factor-kappa B apoptosis pathways in human cervical cancer cells. (2005) Marlene F Shehata. Cancer Cell Int. 2005;5:10-10. Figure: F5.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates IKB-alpha IKBA ncbigene_synonym NFKBIA 4792
Homo sapiens Primates IKB-beta IKBB ncbigene_synonym NFKBIB 4793
Homo sapiens Primates TNF-alpha TNF-ALPHA ncbigene_synonym TNF 7124
Homo sapiens Primates IL-1 IL-1 ncbigene_synonym IL1B 3553
Homo sapiens Primates p65 P65 ncbigene_synonym RELA 5970
Homo sapiens Primates p65 P65 ncbigene_synonym SYT1 6857
Homo sapiens Primates p65 P65 ncbigene_synonym GORASP1 64689
Homo sapiens Primates p65 P65 ncbigene_synonym WNK1 65125
Homo sapiens Primates IKB-epsilon IKBE ncbigene_synonym NFKBIE 4794
Homo sapiens Primates p50 P50 ncbigene_synonym CD40 958
Homo sapiens Primates p50 P50 ncbigene_synonym ARHGEF7 8874
Homo sapiens Primates p50 P50 ncbigene_synonym ASCC1 51008
Homo sapiens Primates p50 P50 ncbigene_synonym H3P40 115482723
Homo sapiens Primates Tax TAX ncbigene_synonym CNTN2 6900
Homo sapiens Primates Bcl-3 BC2 ncbigene_synonym CHMP2A 27243
Homo sapiens Primates LPS LPS ncbigene_synonym IRF6 3664
Homo sapiens Primates P105 P105 ncbigene_synonym CDH13 1012
Homo sapiens Primates P105 P105 ncbigene_synonym SCYL1 57410
Homo sapiens Primates Ikk IKK famplex_relations CHUK 1147
Homo sapiens Primates Ikk IKK famplex_relations IKBKB 3551
Homo sapiens Primates Ikk IKK famplex_relations IKBKG 8517
Homo sapiens Primates Ikk IKK famplex_relations IKBKE 9641
Homo sapiens Primates Ikk IKK famplex_relations TBK1 29110
Homo sapiens Primates p100 P100 ncbigene_synonym CUX1 1523
Homo sapiens Primates p100 P100 ncbigene_synonym NFKB2 4791
Homo sapiens Primates p100 P100 ncbigene_synonym OAS3 4940
Homo sapiens Primates p100 P100 ncbigene_synonym PMEL 6490
Homo sapiens Primates p100 P100 ncbigene_synonym SART3 9733
Homo sapiens Primates p100 P100 ncbigene_synonym TPX2 22974
Homo sapiens Primates p100 P100 ncbigene_synonym SND1 27044
Homo sapiens Primates p100 P100 ncbigene_synonym ASCC2 84164
Homo sapiens Primates LMP-1 LMP1 ncbigene_synonym PDLIM7 9260
Homo sapiens Primates NF-KB NF-KB ncbigene_synonym NFKB1 4790
Homo sapiens Primates Rel REL ncbigene_symbol REL 5966
Homo sapiens Primates RelB RELB ncbigene_symbol RELB 5971
Homo sapiens Primates p52 P52 ncbigene_synonym FKBP4 2288
Homo sapiens Primates p52 P52 ncbigene_synonym GTF2H4 2968
Homo sapiens Primates p52 P52 ncbigene_synonym PMPCB 9512
Homo sapiens Primates p52 P52 ncbigene_synonym PSIP1 11168
Homo sapiens Primates p52 P52 ncbigene_synonym H3P42 115482704
Drosophila melanogaster Invertebrates TNF-alpha TNF-ALPHA ncbigene_synonym egr 36054
Drosophila melanogaster Invertebrates IL-1 IL-1 ncbigene_synonym JIL-1 39241
Drosophila melanogaster Invertebrates p65 P65 ncbigene_synonym dl 35047
Drosophila melanogaster Invertebrates p65 P65 ncbigene_synonym wash 36311
Drosophila melanogaster Invertebrates p50 P50 ncbigene_synonym Hrb27C 33968
Drosophila melanogaster Invertebrates p50 P50 ncbigene_synonym betaTub60D 37888
Drosophila melanogaster Invertebrates p50 P50 ncbigene_synonym Rpt5 42805
Drosophila melanogaster Invertebrates p50 P50 ncbigene_synonym DCTN2-p50 44086
Drosophila melanogaster Invertebrates Bcl-3 BC2 ncbigene_symbol bc2 252134
Drosophila melanogaster Invertebrates Bcl-3 BC1 ncbigene_symbol BC1 5658050
Drosophila melanogaster Invertebrates P105 P105 ncbigene_synonym Caf1-105 36107
Drosophila melanogaster Invertebrates Ikk IKK ncbigene_synonym IKKepsilon 35329
Drosophila melanogaster Invertebrates Ikk IKK ncbigene_synonym key 37967
Drosophila melanogaster Invertebrates Ikk IKK ncbigene_synonym IKKbeta 44432
Drosophila melanogaster Invertebrates p100 P100 ncbigene_synonym Tudor-SN 38045
Drosophila melanogaster Invertebrates p100 P100 ncbigene_synonym Pep 45961
Drosophila melanogaster Invertebrates and AND ncbigene_synonym CkIIbeta 32132
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Andorra 32798
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Anp 43595
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Acam 44913
Drosophila melanogaster Invertebrates NF-KB NF-KB ncbigene_synonym Dif 35045
Drosophila melanogaster Invertebrates NF-KB NF-KB ncbigene_synonym Rel 41087
Drosophila melanogaster Invertebrates p52 P52 ncbigene_synonym mrn 39688
Danio rerio Vertebrates TNF-alpha TNF-ALPHA ncbigene_synonym tnfb 554167
Danio rerio Vertebrates p65 P65 ncbigene_synonym rela 415099
Danio rerio Vertebrates p50 P50 ncbigene_synonym nfkb1 565756
Danio rerio Vertebrates Bcl-3 BC2 ncbigene_synonym chmp2a 798901
Danio rerio Vertebrates p100 P100 ncbigene_synonym nfkb2 415100
Danio rerio Vertebrates Rel REL ncbigene_symbol rel 415101
Danio rerio Vertebrates RelB RELB ncbigene_symbol relb 795414

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID