Molecular mechanism of resveratrol promoting differentiation of preosteoblastic MC3T3-E1 cells based on network pharmacology and experimental validation

KEGG's diagram of the apoptotic signaling pathway, as shown in the figure, the TNF signaling pathway and TNF-a protein play an important role in the activation of apoptosis as the upstream pathway of apoptosis signaling
Molecular mechanism of resveratrol promoting differentiation of preosteoblastic MC3T3-E1 cells based on network pharmacology and experimental validation
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Molecular mechanism of resveratrol promoting differentiation of preosteoblastic MC3T3-E1 cells based on network pharmacology and experimental validation (2024) Yu He, et al. BMC Complement Med Ther. 2024;24(NA). Figure: F4.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates TRAIL TRAIL ncbigene_synonym TNFSF10 8743
Homo sapiens Primates TRAF2 TRAF2 ncbigene_symbol TRAF2 7186
Homo sapiens Primates TRAF2 TRAF2 ncbigene_synonym TANK 10010
Homo sapiens Primates IP3R IP3R ncbigene_synonym ITPR1 3708
Homo sapiens Primates IP3R IP3R ncbigene_synonym ITPR3 3710
Homo sapiens Primates CASP12 CASP12 ncbigene_symbol CASP12 100506742
Homo sapiens Primates PERK PERK ncbigene_synonym EIF2AK3 9451
Homo sapiens Primates Actin ACTIN famplex_relations ACTA1 58
Homo sapiens Primates Actin ACTIN famplex_relations ACTA2 59
Homo sapiens Primates Actin ACTIN famplex_relations ACTB 60
Homo sapiens Primates Actin ACTIN famplex_relations ACTC1 70
Homo sapiens Primates Actin ACTIN famplex_relations ACTG1 71
Homo sapiens Primates Actin ACTIN famplex_relations ACTG2 72
Homo sapiens Primates GZMB GZMB ncbigene_symbol GZMB 3002
Homo sapiens Primates DAXX DAXX ncbigene_symbol DAXX 1616
Homo sapiens Primates FLIP FLIP ncbigene_synonym CFLAR 8837
Homo sapiens Primates FLIP FLIP ncbigene_synonym FIRRM 55732
Homo sapiens Primates CASP6 CASP6 ncbigene_symbol CASP6 839
Homo sapiens Primates ICAD ICAD ncbigene_synonym DFFA 1676
Homo sapiens Primates FADD FADD ncbigene_symbol FADD 8772
Homo sapiens Primates CASP7 CASP7 ncbigene_symbol CASP7 840
Homo sapiens Primates CAD CAD ncbigene_symbol CAD 790
Homo sapiens Primates CAD CAD ncbigene_synonym DFFB 1677
Homo sapiens Primates CAD CAD ncbigene_synonym ACOD1 730249
Homo sapiens Primates TNF TNF ncbigene_symbol TNF 7124
Homo sapiens Primates CASP9 CASP9 ncbigene_symbol CASP9 842
Homo sapiens Primates Bid BID ncbigene_symbol BID 637
Homo sapiens Primates CASP2 CASP2 ncbigene_symbol CASP2 835
Homo sapiens Primates PIDD PIDD ncbigene_synonym PIDD1 55367
Homo sapiens Primates CHOP CHOP ncbigene_synonym DDIT3 1649
Homo sapiens Primates DIABLO DIABLO ncbigene_symbol DIABLO 56616
Homo sapiens Primates ARTS ARTS ncbigene_synonym SEPTIN4 5414
Homo sapiens Primates ARTS ARTS ncbigene_synonym PRPS1 5631
Homo sapiens Primates HTRA2 HTRA2 ncbigene_symbol HTRA2 27429
Homo sapiens Primates ATM ATM ncbigene_symbol ATM 472
Homo sapiens Primates CHC CHC ncbigene_synonym CLTC 1213
Homo sapiens Primates CHC CHC ncbigene_synonym SLC4A1 6521
Homo sapiens Primates Apa APA ncbigene_synonym ENPEP 2028
Homo sapiens Primates NOP NOP ncbigene_synonym OPRL1 4987
Homo sapiens Primates NOP NOP ncbigene_synonym PNOC 5368
Homo sapiens Primates NOP NOP ncbigene_synonym NOL3 8996
Homo sapiens Primates TrkA TRKA ncbigene_synonym NTRK1 4914
Homo sapiens Primates IL-3R IL3R ncbigene_synonym IL3RA 3563
Homo sapiens Primates MAPK MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates PUMA PUMA ncbigene_synonym BBC3 27113
Homo sapiens Primates IKK IKK famplex_relations CHUK 1147
Homo sapiens Primates IKK IKK famplex_relations IKBKB 3551
Homo sapiens Primates IKK IKK famplex_relations IKBKG 8517
Homo sapiens Primates IKK IKK famplex_relations IKBKE 9641
Homo sapiens Primates IKK IKK famplex_relations TBK1 29110
Homo sapiens Primates NEB NEB ncbigene_symbol NEB 4703
Homo sapiens Primates AIF AIF ncbigene_synonym AIFM1 9131
Homo sapiens Primates Bak BAK ncbigene_synonym BAK1 578
Homo sapiens Primates API API ncbigene_synonym SERPINF2 5345
Homo sapiens Primates HRK HRK ncbigene_symbol HRK 8739
Homo sapiens Primates Gadd45 GADD45 ncbigene_synonym GADD45A 1647
Homo sapiens Primates A1 A1 ncbigene_synonym ADRA1D 146
Homo sapiens Primates Pol POL ncbigene_synonym ERVW-4 100616496
Homo sapiens Primates B-2 B2 ncbigene_synonym NEUROD1 4760
Homo sapiens Primates B-2 B2 ncbigene_synonym TUBB4B 10383

Chemical mentions

Word Match MeSH Name ChEBI
E-L E-L L-alpha-glutamyl-L-leucine chebi:73506
PERK PERK tetrachloroethene chebi:17300
Protein Protein a protein chebi:16541
Effector effector effector chebi:35224
CHOP ChoP N,N,N-trimethyl-2-(phosphonooxy)ethanaminium chebi:18132
Pro- Pro- (2S)-pyrrolidine-2-carbonyl chebi:32865
Apa APA 6beta-[(2R)-2-amino-2-phenylacetamido]-2,2-dimethylpenam-3alpha-carbonyl chebi:53713
DNA DNA deoxyribonucleic acids chebi:16991
NOP NOP chebi:7440
DNA DNA deoxyribonucleic acids chebi:16991
DNA DNA deoxyribonucleic acids chebi:16991
DNA DNA deoxyribonucleic acids chebi:16991

Disease mentions

Word Match MeSH Name DOID
purpura purpura purpura DOID:3326