Hippo signaling pathway and its network

Hippo signaling pathway and its network. When upstream signals activate the Hippo pathway (Hippo ON), the phosphorylation cascade is enabled that ultimately induces YAP/TAZ proteasomal degradation (leftside). In Hippo OFF conformation, promoted by mechanical signaling and hormones, YAP/TAZ can translocate to the nucleus. Here, by interacting with TEAD transcription factors and cofactors, YAP/TAZ activate the transcription of target genes. ABCP: apico-basal cell polarity protein; AMOT: angiomotin; AMPK: AMP-activated protein kinase; AREG: amphiregulin; CTGF: connective tissue growth factor; CRB: crumbs; CYR61: Cysteine-rich angiogenic inducer 61; KIBRA: kidney and brain expressed protein; NF2: neurofibromin 2; RUNX2: Runt-related transcription factor 2; SCD1: Stearoyl-CoA-desaturase-1; SMAD: small mother against decapentaplegic; TAO: thousand-and-one amino acid
Hippo signaling pathway and its network
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Publication

Role of Hippo pathway dysregulation from gastrointestinal premalignant lesions to cancer (2024) Giulia Schiavoni, et al. J Transl Med. 2024;22(NA). Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates NF2 NF2 ncbigene_symbol NF2 4771
Homo sapiens Primates KIBRA KIBRA ncbigene_synonym WWC1 23286
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA1 5562
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA2 5563
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAB1 5564
Homo sapiens Primates AMPK AMPK famplex_relations PRKAB2 5565
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG1 5571
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG2 51422
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG3 53632
Homo sapiens Primates TEAD TEAD famplex_relations TEAD1 7003
Homo sapiens Primates TEAD TEAD famplex_relations TEAD2 8463
Homo sapiens Primates TEAD TEAD famplex_relations TEAD3 7005
Homo sapiens Primates TEAD TEAD famplex_relations TEAD4 7004
Homo sapiens Primates SAV1 SAV1 ncbigene_symbol SAV1 60485
Homo sapiens Primates MST1/2 MST1 ncbigene_symbol MST1 4485
Homo sapiens Primates MST1/2 MST1 ncbigene_synonym STK4 6789
Homo sapiens Primates MST1/2 MST2 ncbigene_synonym STK3 6788
Homo sapiens Primates MOB1a MOB1A ncbigene_symbol MOB1A 55233
Homo sapiens Primates MOB1a/b MOB1B ncbigene_symbol MOB1B 92597
Homo sapiens Primates LATS1/2 LATS2 ncbigene_symbol LATS2 26524
Homo sapiens Primates LATS1/2 LATS1 ncbigene_symbol LATS1 9113
Homo sapiens Primates SCD1 SCD1 ncbigene_synonym SCD 6319
Homo sapiens Primates YAP YAP ncbigene_synonym YAP1 10413
Homo sapiens Primates TAZ TAZ ncbigene_synonym TAFAZZIN 6901
Homo sapiens Primates TAZ TAZ ncbigene_synonym WWTR1 25937
Homo sapiens Primates CTGF CTGF ncbigene_synonym CCN2 1490
Homo sapiens Primates CYR61 CYR61 ncbigene_synonym CCN1 3491
Homo sapiens Primates SMAD SMAD famplex_relations SMAD1 4086
Homo sapiens Primates SMAD SMAD famplex_relations SMAD4 4089
Homo sapiens Primates SMAD SMAD famplex_relations SMAD5 4090
Homo sapiens Primates SMAD SMAD famplex_relations SMAD6 4091
Homo sapiens Primates SMAD SMAD famplex_relations SMAD7 4092
Homo sapiens Primates SMAD SMAD famplex_relations SMAD9 4093
Homo sapiens Primates SMAD SMAD famplex_relations SMAD2 4087
Homo sapiens Primates SMAD SMAD famplex_relations SMAD3 4088
Homo sapiens Primates AREG AREG ncbigene_symbol AREG 374
Homo sapiens Primates RUNX2 RUNX2 ncbigene_symbol RUNX2 860
Homo sapiens Primates MYC MYC ncbigene_symbol MYC 4609

Chemical mentions

Word Match MeSH Name ChEBI
TEA TEA N,N-diethylethanamine chebi:35026
NUCLEUS nucleus nucleus chebi:33252
NUCLEUS nucleus nucleus chebi:33252
TEA TEA N,N-diethylethanamine chebi:35026

Disease mentions

Word Match MeSH Name DOID