Prevotella along with NR supplements improving the signaling pathway of BCAA metabolism in MASLDNAD precursor supplements can affect fatty acid oxidation and lipid synthesis as well as the TCA cycle and insulin sensitivity

Prevotella along with NR supplements improving the signaling pathway of BCAA metabolism in MASLDNAD precursor supplements can affect fatty acid oxidation and lipid synthesis as well as the TCA cycle and insulin sensitivity. Simultaneously, Prevotella may mediate the improvement of BCAA metabolism and corresponding signaling pathways after NR supplementation, playing a synergistic role with NR supplementation in improving BCAA metabolism in MASLD. (Created with BioRender.com)
Prevotella along with NR supplements improving the signaling pathway of BCAA metabolism in MASLDNAD precursor supplements can affect fatty acid oxidation and lipid synthesis as well as the TCA cycle and insulin sensitivity
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Publication

NAD metabolic therapy in metabolic dysfunction-associated steatotic liver disease: Possible roles of gut microbiota (2024) Xinyi Lu, et al. iScience. 2024 Mar 15;27(3). Figure: F3.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates BCKDK↓ BCKDK ncbigene_symbol BCKDK 10295
Homo sapiens Primates GLUT1,GLUT4 GLUT4 ncbigene_synonym SLC2A4 6517
Homo sapiens Primates GLUT1,GLUT4 GLUT1 ncbigene_synonym SLC2A1 6513
Homo sapiens Primates BCAAs BCAA ncbigene_synonym ARID4B 51742
Homo sapiens Primates NAMPT↑ NAMPT ncbigene_symbol NAMPT 10135
Homo sapiens Primates Akt2↓ AKT2 ncbigene_symbol AKT2 208
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA1 5562
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA2 5563
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAB1 5564
Homo sapiens Primates AMPK AMPK famplex_relations PRKAB2 5565
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG1 5571
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG2 51422
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG3 53632
Homo sapiens Primates PPARα PPAR ncbigene_synonym PPARA 5465
Homo sapiens Primates PPARα PPAR famplex_relations PPARD 5467
Homo sapiens Primates PPARα PPAR famplex_relations PPARG 5468
Homo sapiens Primates SIRT1 SIRT1 ncbigene_symbol SIRT1 23411
Homo sapiens Primates PGC1α, PGC1 ncbigene_synonym PPARGC1A 10891
Homo sapiens Primates UCP3 UCP3 ncbigene_symbol UCP3 7352
Homo sapiens Primates UCP2, UCP2 ncbigene_symbol UCP2 7351
Homo sapiens Primates SREBP1 SREBP1 ncbigene_synonym SREBF1 6720
Homo sapiens Primates TRB3↓ TRB3 ncbigene_synonym TAS2R13 50838
Homo sapiens Primates TRB3↓ TRB3 ncbigene_synonym TRIB3 57761
Homo sapiens Primates FAS FAS ncbigene_symbol FAS 355
Homo sapiens Primates FAS FAS ncbigene_synonym FASN 2194
Homo sapiens Primates ACC ACC ncbigene_synonym ACACA 31
Homo sapiens Primates ACC ACC ncbigene_synonym BMS1 9790
Homo sapiens Primates ACC ACC famplex_relations ACACB 32

Chemical mentions

Word Match MeSH Name ChEBI
TCA TCA trichloroacetic acid chebi:30956
FAS FAS ammonium iron(2+) sulfate--water (1/6) chebi:76181
Fatty Acid Fatty acid fatty acids chebi:35366
ACC ACC 1-aminocyclopropane-1-carboxylate chebi:30526

Disease mentions

Word Match MeSH Name DOID