Signalling pathways for EGF activation of c-jun

Model of signalling pathways for EGF activation of c-jun. Components for signalling pathways to the c-jun promoter and for phosphorylation of c-Jun protein are shown and are described in the text. The pathway for induction of the c-jun promoter downstream of MEKK is unknown and may involve JNK and/or a separate pathway as indicated by the question marks. Two arrows between components indicate that the activation of the protein is not direct.
Signalling pathways for EGF activation of c-jun
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Publication

Epidermal Growth Factor Induction of the c-jun Promoter by a Rac Pathway. (1998) Nicole Clarke, et al. Mol Cell Biol. 1998 Feb;18(2):1065-1073. Figure: F8.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates EGF EGF ncbigene_symbol EGF 1950
Homo sapiens Primates rac RAC ncbigene_synonym AKT1 207
Homo sapiens Primates rac RAC famplex_relations RAC1 5879
Homo sapiens Primates rac RAC famplex_relations RAC2 5880
Homo sapiens Primates rac RAC famplex_relations RAC3 5881
Homo sapiens Primates rac RAC famplex_relations RHOG 391
Homo sapiens Primates ras RAS famplex_relations KRAS 3845
Homo sapiens Primates ras RAS famplex_relations HRAS 3265
Homo sapiens Primates ras RAS famplex_relations NRAS 4893
Homo sapiens Primates sos SOS ncbigene_synonym XYLT2 64132
Homo sapiens Primates sos SOS famplex_relations SOS1 6654
Homo sapiens Primates sos SOS famplex_relations SOS2 6655
Homo sapiens Primates GRB-2 GRB2 ncbigene_symbol GRB2 2885
Homo sapiens Primates MEKK1 MEKK1 ncbigene_synonym MAP3K1 4214
Homo sapiens Primates JNKK JNKK ncbigene_synonym MAP2K4 6416
Homo sapiens Primates JNK JNK ncbigene_synonym MAPK8 5599
Homo sapiens Primates JNK JNK famplex_relations MAPK9 5601
Homo sapiens Primates JNK JNK famplex_relations MAPK10 5602
Homo sapiens Primates c-jun C-JUN ncbigene_synonym JUN 3725
Homo sapiens Primates ATF1 ATF1 ncbigene_symbol ATF1 466
Homo sapiens Primates ATF1 ATF1 ncbigene_synonym GDNF 2668
Homo sapiens Primates (MEF2D MEF2D ncbigene_symbol MEF2D 4209

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID