Signaling pathway of NGF-induced neurite outgrowth in PC12 cells

Schematic representation of signaling pathway of NGF-induced neurite outgrowth in PC12 cells. In the early phase (0–10 min), global activation of PI3-kinase upon NGF stimulation recruited Vav2 and Vav3 to activate Rac1/Cdc42 in broad areas. Lamellipodial protrusion at the cell periphery was concomitantly observed. Sos1 partially mediated Cdc42 activation only in cell bodies immediately after NGF addition. In the late phase (10–30 min), NGF/TrkA signaling drives a cycling of positive feedback loop comprised of PI3-kinase, Vav2/3, Rac1/Cdc42, and actin cytoskeleton; this feedback loop promotes neurite outgrowth by regulating morphological dynamics.
Signaling pathway of NGF-induced neurite outgrowth in PC12 cells
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Publication

Local Phosphatidylinositol 3,4,5-Trisphosphate Accumulation Recruits Vav2 and Vav3 to Activate Rac1/Cdc42 and Initiate Neurite Outgrowth in Nerve Growth Factor-stimulated PC12 Cells. (2005) Kazuhiro Aoki, et al. Mol Biol Cell. 2005 May;16(5):2207-2217. Figure: F8.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates NGF NGF ncbigene_symbol NGF 4803
Homo sapiens Primates TrkA TRKA ncbigene_synonym NTRK1 4914
Homo sapiens Primates Sos1 SOS1 ncbigene_symbol SOS1 6654
Homo sapiens Primates Vav2/3 VAV3 ncbigene_symbol VAV3 10451
Homo sapiens Primates Vav2/3 VAV2 ncbigene_symbol VAV2 7410
Homo sapiens Primates Rac1/Cdc42- RAC1 ncbigene_symbol RAC1 5879
Homo sapiens Primates Rac1/Cdc42- RAC1 ncbigene_synonym RNASE1 6035
Homo sapiens Primates Cdc42 CDC42 ncbigene_symbol CDC42 998
Homo sapiens Primates actin ACTIN famplex_relations ACTA1 58
Homo sapiens Primates actin ACTIN famplex_relations ACTA2 59
Homo sapiens Primates actin ACTIN famplex_relations ACTB 60
Homo sapiens Primates actin ACTIN famplex_relations ACTC1 70
Homo sapiens Primates actin ACTIN famplex_relations ACTG1 71
Homo sapiens Primates actin ACTIN famplex_relations ACTG2 72
Rattus norvegicus Rodents NGF NGF ncbigene_symbol Ngf 310738
Rattus norvegicus Rodents Sos1 SOS1 ncbigene_symbol Sos1 313845
Rattus norvegicus Rodents Sos1 SOS1 ncbigene_synonym Sos2 85384
Rattus norvegicus Rodents Vav2/3 VAV3 ncbigene_symbol Vav3 295378
Rattus norvegicus Rodents Vav2/3 VAV2 ncbigene_symbol Vav2 296603
Rattus norvegicus Rodents Rac1/Cdc42- RAC1 ncbigene_symbol Rac1 363875
Rattus norvegicus Rodents Rac1/Cdc42- RAC1 ncbigene_synonym Rnase1l1 364303
Rattus norvegicus Rodents Cdc42 CDC42 ncbigene_symbol Cdc42 64465
Danio rerio Vertebrates NGF NGF ncbigene_synonym ngfb 58133
Danio rerio Vertebrates TrkA TRKA ncbigene_synonym ntrk1 30546
Danio rerio Vertebrates Sos1 SOS1 ncbigene_symbol sos1 556286
Danio rerio Vertebrates Vav2/3 VAV3 ncbigene_symbol vav3 100333179
Danio rerio Vertebrates Vav2/3 VAV2 ncbigene_symbol vav2 556413
Danio rerio Vertebrates Rac1/Cdc42- RAC1 ncbigene_synonym rac1a 327204
Danio rerio Vertebrates Cdc42 CDC42 ncbigene_symbol cdc42 336839
Danio rerio Vertebrates Cdc42 CDC42 ncbigene_synonym cdc42l 793158

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID