Macrophage TSC1-mediated AKT/MST1/NRF2 signaling pathway in I/R-triggered liver inflammation

Schematic illustration of macrophage TSC1-mediated AKT/MST1/NRF2 signaling pathway in I/R-triggered liver inflammation. Macrophage TSC1 can be activated in I/R-stressed livers. TSC1 activation promotes phosphorylation of AKT and MST1, which in turn increases NRF2 expression and inhibits ROS production and TLR4/NF-κB activation, resulting in reduced hepatocellular apoptosis in I/R-triggered liver injury
Macrophage TSC1-mediated AKT/MST1/NRF2 signaling pathway in I/R-triggered liver inflammation
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Publication

Loss of macrophage TSC1 exacerbates sterile inflammatory liver injury through inhibiting the AKT/MST1/NRF2 signaling pathway (2024) Ming Ni, et al. Cell Death Dis. 2024 Feb;15(2). Figure: F0.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates HMGB1, HMGB1 ncbigene_symbol HMGB1 3146
Homo sapiens Primates TLR4 TLR4 ncbigene_symbol TLR4 7099
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates TSC1 TSC1 ncbigene_symbol TSC1 7248
Homo sapiens Primates TSC1 TSC1 ncbigene_synonym CCL26 10344
Homo sapiens Primates HO-1, HO-1 ncbigene_synonym HMOX1 3162
Homo sapiens Primates MST1 MST1 ncbigene_symbol MST1 4485
Homo sapiens Primates MST1 MST1 ncbigene_synonym STK4 6789
Homo sapiens Primates NRF2 NRF2 ncbigene_synonym GABPA 2551
Homo sapiens Primates NRF2 NRF2 ncbigene_synonym NFE2L2 4780
Homo sapiens Primates KEAP1 KEAP1 ncbigene_symbol KEAP1 9817
Homo sapiens Primates TRAF6 TRAF6 ncbigene_symbol TRAF6 7189
Homo sapiens Primates NF-kB NF-KB ncbigene_synonym NFKB1 4790
Homo sapiens Primates TNF-a TNF-A ncbigene_synonym TNF 7124
Homo sapiens Primates IL-6 IL-6 ncbigene_synonym IL6 3569
Homo sapiens Primates IL-1ẞ IL1 ncbigene_synonym IL1A 3552
Homo sapiens Primates IL-1ẞ IL1 ncbigene_synonym IL1B 3553

Chemical mentions

Word Match MeSH Name ChEBI
ROS ROS chebi:26523
TNF-a TNF-a chebi:197439

Disease mentions

Word Match MeSH Name DOID