JAK-STAT signaling pathway and PI3K-AKT signaling pathway that affect AD
The JAK-STAT signaling pathway and PI3K-AKT signaling pathway that affect AD. Red text indicates the genes that are commonly included in the JAK-STAT and PI3K-AKT signaling pathways in all BPA, BPF, and BPS exposure groups from the DMR analysis. Hypomethylated genes can be hyperregulated, which can cause the proliferation, regeneration, apoptosis of keratinocytes in the PI3K-AKT signaling pathway, and skin barrier dysfunction in the JAK-STAT signaling pathway. Figure created using BioRender (https://biorender.com/, accessed on 12 October 2023)
Publication
Epigenetic Methylation Changes in Pregnant Women: Bisphenol Exposure and Atopic Dermatitis (2024) Seung Hwan Kim, et al. Int J Mol Sci. 2024 Feb;25(3). Figure: F2.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | IRS-1 | IRS1 | ncbigene_symbol | IRS1 | 3667 |
| Homo sapiens | Primates | IRS-1/2 | IRS-2 | ncbigene_synonym | IRS2 | 8660 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CA | 5290 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CB | 5291 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CD | 5293 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CG | 5294 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R3 | 8503 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R4 | 30849 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R5 | 23533 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R6 | 146850 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R1 | 5295 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R2 | 5296 |
| Homo sapiens | Primates | AKT | AKT | ncbigene_synonym | AKT1 | 207 |
| Homo sapiens | Primates | AKT | AKT | famplex_relations | AKT2 | 208 |
| Homo sapiens | Primates | AKT | AKT | famplex_relations | AKT3 | 10000 |
| Homo sapiens | Primates | IL-4 | IL-4 | ncbigene_synonym | IL4 | 3565 |
| Homo sapiens | Primates | IL-4Ra | IL-4RA | ncbigene_synonym | IL4R | 3566 |
| Homo sapiens | Primates | IL-13Ra1 | IL13RA1 | ncbigene_symbol | IL13RA1 | 3597 |
| Homo sapiens | Primates | JAK1 | JAK1 | ncbigene_symbol | JAK1 | 3716 |
| Homo sapiens | Primates | TYK2 | TYK2 | ncbigene_symbol | TYK2 | 7297 |
| Homo sapiens | Primates | STAT6 | STAT6 | ncbigene_symbol | STAT6 | 6778 |
| Homo sapiens | Primates | STAT3 | STAT3 | ncbigene_symbol | STAT3 | 6774 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|