SOX TFs acts as the hub of signaling pathways in the tumorigenesis

SOX TFs in critical positions of the signaling pathway that mediates EMT [76, 82, 85, 87, 132, 78–80, 86], invasion and metastasis [91–93, 96, 135], proliferation and apoptosis [59, 97, 99, 123, 124, 128], stemness of cancer [104, 105, 107, 108, 110, 111]
SOX TFs acts as the hub of signaling pathways in the tumorigenesis
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Publication

SOX on tumors, a comfort or a constraint? (2024) Junqing Jiang, et al. Cell Death Discov. 2024;10(NA). Figure: F4.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates TGF-B TGFB ncbigene_synonym TGFB1 7040
Homo sapiens Primates TGF-B TGFB famplex_relations TGFB2 7042
Homo sapiens Primates TGF-B TGFB famplex_relations TGFB3 7043
Homo sapiens Primates c-MET C-MET ncbigene_synonym MET 4233
Homo sapiens Primates HGF HGF ncbigene_symbol HGF 3082
Homo sapiens Primates HGF HGF ncbigene_synonym IL6 3569
Homo sapiens Primates HGF HGF ncbigene_synonym SOS1 6654
Homo sapiens Primates (MTA1) MTA1 ncbigene_symbol MTA1 9112
Homo sapiens Primates SMAD2/3) SMAD2 ncbigene_symbol SMAD2 4087
Homo sapiens Primates FoxQ1 FOXQ1 ncbigene_symbol FOXQ1 94234
Homo sapiens Primates STAT STAT ncbigene_synonym SOAT1 6646
Homo sapiens Primates STAT STAT famplex_relations STAT1 6772
Homo sapiens Primates STAT STAT famplex_relations STAT2 6773
Homo sapiens Primates STAT STAT famplex_relations STAT3 6774
Homo sapiens Primates STAT STAT famplex_relations STAT4 6775
Homo sapiens Primates STAT STAT famplex_relations STAT6 6778
Homo sapiens Primates STAT STAT famplex_relations STAT5A 6776
Homo sapiens Primates STAT STAT famplex_relations STAT5B 6777
Homo sapiens Primates JAK JAK famplex_relations JAK1 3716
Homo sapiens Primates JAK JAK famplex_relations JAK2 3717
Homo sapiens Primates JAK JAK famplex_relations JAK3 3718
Homo sapiens Primates JAK JAK famplex_relations TYK2 7297
Homo sapiens Primates FGF19 FGF19 ncbigene_symbol FGF19 9965
Homo sapiens Primates FGFR4 FGFR4 ncbigene_symbol FGFR4 2264
Homo sapiens Primates CCR1 CCR1 ncbigene_symbol CCR1 1230
Homo sapiens Primates FRS2 FRS2 ncbigene_symbol FRS2 10818
Homo sapiens Primates GSK3B GSK3B ncbigene_symbol GSK3B 2932
Homo sapiens Primates ERK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates ERK ERK ncbigene_synonym MAPK1 5594
Homo sapiens Primates ERK ERK famplex_relations MAPK3 5595
Homo sapiens Primates SOX30 SOX30 ncbigene_symbol SOX30 11063
Homo sapiens Primates (SOX1 SOX1 ncbigene_symbol SOX1 6656
Homo sapiens Primates SOX2 SOX2 ncbigene_symbol SOX2 6657
Homo sapiens Primates SOX4 SOX4 ncbigene_symbol SOX4 6659
Homo sapiens Primates SOX9) SOX9 ncbigene_symbol SOX9 6662
Homo sapiens Primates SOX11 SOX11 ncbigene_symbol SOX11 6664
Homo sapiens Primates (SOX13) SOX13 ncbigene_symbol SOX13 9580
Homo sapiens Primates SOX12 SOX12 ncbigene_symbol SOX12 6666
Homo sapiens Primates (SOX18) SOX18 ncbigene_symbol SOX18 54345
Homo sapiens Primates EZH2) EZH2 ncbigene_symbol EZH2 2146
Homo sapiens Primates (n-MYC NMYC ncbigene_synonym MYCN 4613
Homo sapiens Primates CREB CREB ncbigene_synonym CREB1 1385
Homo sapiens Primates CREB CREB famplex_relations CREB3 10488
Homo sapiens Primates CREB CREB famplex_relations CREB5 9586
Homo sapiens Primates CREB CREB famplex_relations CREB3L1 90993
Homo sapiens Primates CREB CREB famplex_relations CREB3L2 64764
Homo sapiens Primates CREB CREB famplex_relations CREB3L3 84699
Homo sapiens Primates CREB CREB famplex_relations CREB3L4 148327
Homo sapiens Primates CREB CREB famplex_relations CREM 1390
Homo sapiens Primates CREB CREB famplex_relations ATF1 466
Homo sapiens Primates CREB CREB famplex_relations ATF2 1386
Homo sapiens Primates Wnt/ẞ- WNT famplex_relations WNT1 7471
Homo sapiens Primates Wnt/ẞ- WNT famplex_relations WNT2 7472
Homo sapiens Primates Wnt/ẞ- WNT famplex_relations WNT2B 7482
Homo sapiens Primates Wnt/ẞ- WNT famplex_relations WNT3 7473
Homo sapiens Primates Wnt/ẞ- WNT famplex_relations WNT3A 89780
Homo sapiens Primates Wnt/ẞ- WNT famplex_relations WNT4 54361
Homo sapiens Primates Wnt/ẞ- WNT famplex_relations WNT6 7475
Homo sapiens Primates Wnt/ẞ- WNT famplex_relations WNT7A 7476
Homo sapiens Primates Wnt/ẞ- WNT famplex_relations WNT7B 7477
Homo sapiens Primates Wnt/ẞ- WNT famplex_relations WNT8A 7478
Homo sapiens Primates Wnt/ẞ- WNT famplex_relations WNT8B 7479
Homo sapiens Primates Wnt/ẞ- WNT famplex_relations WNT9A 7483
Homo sapiens Primates Wnt/ẞ- WNT famplex_relations WNT9B 7484
Homo sapiens Primates Wnt/ẞ- WNT famplex_relations WNT10A 80326
Homo sapiens Primates Wnt/ẞ- WNT famplex_relations WNT10B 7480
Homo sapiens Primates Wnt/ẞ- WNT famplex_relations WNT11 7481
Homo sapiens Primates Wnt/ẞ- WNT famplex_relations WNT16 51384
Homo sapiens Primates Wnt/ẞ- WNT famplex_relations WNT5A 7474
Homo sapiens Primates Wnt/ẞ- WNT famplex_relations WNT5B 81029
Homo sapiens Primates PSP PSP ncbigene_synonym MSMB 4477
Homo sapiens Primates PSP PSP ncbigene_synonym PSPN 5623
Homo sapiens Primates PSP PSP ncbigene_synonym PSPH 5723
Homo sapiens Primates PSP PSP ncbigene_synonym REG1A 5967
Homo sapiens Primates PSP PSP ncbigene_synonym STXBP3 6814
Homo sapiens Primates PSP PSP ncbigene_synonym RIDA 10247
Homo sapiens Primates PSP PSP ncbigene_synonym BPIFA2 140683
Homo sapiens Primates DSC3 DSC3 ncbigene_symbol DSC3 1825
Homo sapiens Primates DSC3 DSC3 ncbigene_synonym DSC2 1824
Homo sapiens Primates TWIST1) TWIST1 ncbigene_symbol TWIST1 7291
Homo sapiens Primates ALK ALK ncbigene_symbol ALK 238
Homo sapiens Primates FGFBP1 FGFBP1 ncbigene_symbol FGFBP1 9982
Homo sapiens Primates (SNAIL SNAIL ncbigene_synonym SNAI1 6615
Homo sapiens Primates GLS GLS ncbigene_symbol GLS 2744
Homo sapiens Primates GLS GLS ncbigene_synonym GLS2 27165
Homo sapiens Primates РІЗКАКТ KAT ncbigene_synonym KATNB1 10300
Homo sapiens Primates РІЗКАКТ KAT ncbigene_synonym F11R 50848
Homo sapiens Primates РІЗКАКТ KAT ncbigene_synonym TSTD1 100131187
Homo sapiens Primates JUP JUP ncbigene_symbol JUP 3728
Homo sapiens Primates GOT2 GOT2 ncbigene_symbol GOT2 2806
Homo sapiens Primates MCAM MCAM ncbigene_symbol MCAM 4162
Homo sapiens Primates PDGFRB PDGFRB ncbigene_symbol PDGFRB 5159
Homo sapiens Primates (ITGA5) ITGA5 ncbigene_symbol ITGA5 3678
Homo sapiens Primates IGF1 IGF1 ncbigene_symbol IGF1 3479
Homo sapiens Primates AKT/NF-KB NF-KB ncbigene_synonym NFKB1 4790
Homo sapiens Primates AKT/NF-KB AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT/NF-KB AKT famplex_relations AKT2 208
Homo sapiens Primates AKT/NF-KB AKT famplex_relations AKT3 10000
Homo sapiens Primates ASNS ASNS ncbigene_symbol ASNS 440
Homo sapiens Primates SLUG SLUG ncbigene_synonym SNAI2 6591
Homo sapiens Primates MMP7 MMP7 ncbigene_symbol MMP7 4316
Homo sapiens Primates (FLT4) FLT4 ncbigene_symbol FLT4 2324
Homo sapiens Primates (CCL7) CCL7 ncbigene_symbol CCL7 6354
Homo sapiens Primates N-cadherin,Vitmentin,Fibronectin CDH2 ncbigene_symbol CDH2 1000
Homo sapiens Primates ZO-1 ZO-1 ncbigene_synonym TJP1 7082
Homo sapiens Primates E-cadherin, CDH1 ncbigene_symbol CDH1 999
Homo sapiens Primates E-cadherin, CDH1 ncbigene_synonym FZR1 51343
Homo sapiens Primates IL6R IL6R ncbigene_symbol IL6R 3570
Homo sapiens Primates CD73 CD73 ncbigene_synonym NT5E 4907
Homo sapiens Primates EWS-FLI1) EWSFLI1 ncbigene_synonym EWSR1 2130
Homo sapiens Primates ETV6 ETV6 ncbigene_symbol ETV6 2120
Homo sapiens Primates (SOX7) SOX7 ncbigene_symbol SOX7 83595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates (c-MYC) CMYC ncbigene_synonym MYC 4609
Homo sapiens Primates Notch NOTCH famplex_relations NOTCH1 4851
Homo sapiens Primates Notch NOTCH famplex_relations NOTCH2 4853
Homo sapiens Primates Notch NOTCH famplex_relations NOTCH3 4854
Homo sapiens Primates Notch NOTCH famplex_relations NOTCH4 4855
Homo sapiens Primates IGF2BP2) IGF2BP2 ncbigene_symbol IGF2BP2 10644
Homo sapiens Primates (DHX9) DHX9 ncbigene_symbol DHX9 1660
Homo sapiens Primates GSCAR GSCAR ncbigene_symbol GSCAR 124901024
Homo sapiens Primates NLRP3) NLRP3 ncbigene_symbol NLRP3 114548
Homo sapiens Primates (E2F1) E2F1 ncbigene_symbol E2F1 1869
Homo sapiens Primates (E2F1) E2F1 ncbigene_synonym UBE2L3 7332
Homo sapiens Primates (BIM) BIM ncbigene_synonym BCL2L11 10018
Homo sapiens Primates BMF BMF ncbigene_symbol BMF 90427
Homo sapiens Primates NUMB NUMB ncbigene_symbol NUMB 8650
Homo sapiens Primates (PROM1) PROM1 ncbigene_symbol PROM1 8842
Homo sapiens Primates (SRSF1 SRSF1 ncbigene_symbol SRSF1 6426

Chemical mentions

Word Match MeSH Name ChEBI
Nucleus nucleus nucleus chebi:33252
Nucleus nucleus nucleus chebi:33252
PSP PSP 4,4'-(1,1-dioxido-3H-2,1-benzoxathiole-3,3-diyl)diphenol chebi:31991
Asparagine ASPARAGINE L-asparagine chebi:17196
Nucleus nucleus nucleus chebi:33252

Disease mentions

Word Match MeSH Name DOID