FGF/FGFR and downstream signaling pathway

FGF/FGFR and downstream signaling pathway. Description: The binding of FGF ligands to FGFRs leads to receptor dimerization, conformational changes, and phosphorylation (P in figure) of kinases, leading to the interaction of adaptor protein FRS2 (FGFR substrate 2) with SHP2 (Src homology-2 domain-containing protein tyrosine phosphatase-2), GRB2 (growth factor receptor-bound 2), SOS (son of sevenless). This subsequently leads to the downstream activation of the PI3K, and MAPK signaling pathways. In addition, the activation of JAK-STAT and protein kinase C (PKC) pathways occurs independently of FRS2. The activation of the PKC pathway occurs via binding of phospholipase C-gamma (PLCγ) to phosphotyrosine, causing hydrolyzation of PIP2 (Phosphatidylinositol 4,5-bisphosphate) to PIP3 (Phosphatidylinositol (3,4,5)-trisphosphate) and DAG (diacylglycerol), which in turn leads to activation of PKC and MAPK pathways

Publication

Molecular Targeting of the Fibroblast Growth Factor Receptor Pathway across Various Cancers (2024) Khine S. Shan, et al. Int J Mol Sci. 2024 Jan;25(2). Figure: F1. Homo sapiens

Disease mentions