Schematic diagram depicting the miRNA signaling pathways activated by aldosterone through the MR

A schematic diagram depicting the miRNA signaling pathways activated by aldosterone through the MR. These miRNAs impact different aspects of the aldosterone and MR pathway and subsequent molecular processes, which affect sodium balance, ion transport, and the regulation of fibrosis. Red lines represent enhanced expression, whereas blue arrows denote repression. Several miRNAs induced by aldosterone might provide negative feedback to regulate components of the RAAS signaling pathway. MR, mineralocorticoid receptor; ROMK, renal outer medullary potassium; ENaC, epithelial sodium channel; ECM, extracellular matrix; EMT, epithelial–mesenchymal transition
Schematic diagram depicting the miRNA signaling pathways activated by aldosterone through the MR
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Publication

Potential of Modulating Aldosterone Signaling and Mineralocorticoid Receptor with microRNAs to Attenuate Diabetic Kidney Disease (2024) Shinji Hagiwara, et al. Int J Mol Sci. 2024 Jan;25(2). Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates miR-324 MIR-324 ncbigene_synonym MIR324 442898
Homo sapiens Primates ELAVL1 ELAVL1 ncbigene_symbol ELAVL1 1994
Homo sapiens Primates miR-192 MIR-192 ncbigene_synonym MIR192 406967
Homo sapiens Primates WNK1 WNK1 ncbigene_symbol WNK1 65125
Homo sapiens Primates HSD11B2 HSD11B2 ncbigene_symbol HSD11B2 3291
Homo sapiens Primates miR-20a MIR-20A ncbigene_synonym MIR20A 406982
Homo sapiens Primates miR-766 MIR-766 ncbigene_synonym MIR766 768218
Homo sapiens Primates miR-34c MIR-34C ncbigene_synonym MIR34C 407042
Homo sapiens Primates miR-802 MIR802 ncbigene_symbol MIR802 768219
Homo sapiens Primates miR-27a/b MIR-27A ncbigene_synonym MIR27A 407018
Homo sapiens Primates miR-27a/b MIR-27B ncbigene_synonym MIR27B 407019
Homo sapiens Primates miR-21 MIR-21 ncbigene_synonym MIR21 406991
Homo sapiens Primates CAMK2B CAMK2B ncbigene_symbol CAMK2B 816
Homo sapiens Primates SGK1 SGK1 ncbigene_symbol SGK1 6446
Homo sapiens Primates TUG1 TUG1 ncbigene_symbol TUG1 55000
Homo sapiens Primates CAV1 CAV1 ncbigene_symbol CAV1 857
Homo sapiens Primates ITSN1/2 ITSN2 ncbigene_symbol ITSN2 50618
Homo sapiens Primates ITSN1/2 ITSN1 ncbigene_symbol ITSN1 6453
Homo sapiens Primates miR-196b MIR-196B ncbigene_synonym MIR196B 442920
Homo sapiens Primates SMAD7 SMAD7 ncbigene_symbol SMAD7 4092
Homo sapiens Primates miR-29b MIR-29B ncbigene_synonym MIR29B1 407024
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates TIMP3 TIMP3 ncbigene_symbol TIMP3 7078
Homo sapiens Primates ROMK ROMK ncbigene_synonym KCNJ1 3758
Homo sapiens Primates EMT EMT ncbigene_synonym ITK 3702
Homo sapiens Primates EMT EMT ncbigene_synonym SLC22A3 6581

Chemical mentions

Word Match MeSH Name ChEBI
Aldosterone aldosterone aldosterone chebi:27584
Aldosterone aldosterone aldosterone chebi:27584

Disease mentions

Word Match MeSH Name DOID