IFITM3-mediated activation of TRAF6/MAPK/AP-1 pathways induces acquired TKI resistance in clear cell renal cell carcinoma

The interferon-induced transmembrane protein 3 (IFITM3)-induced acquired tyrosine kinase inhibitor (TKI) resistance mechanism represented in a schematic diagram. In patients resistant to sunitinib, overexpression of IFITM3 is observed. The binding of IFITM3 to TRAF6 leads to the activation of TRAF6 associated with IRAK1, which induces oncogenic signaling pathways, including MAPK/AP-1 pathways. As a result, clear cell renal cell carcinoma (ccRCC) can accelerate tumor growth, survival, and proliferation despite TKI treatment
IFITM3-mediated activation of TRAF6/MAPK/AP-1 pathways induces acquired TKI resistance in clear cell renal cell carcinoma
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IFITM3-mediated activation of TRAF6/MAPK/AP-1 pathways induces acquired TKI resistance in clear cell renal cell carcinoma (2024) Se Un Jeong, et al. Investig Clin Urol. 2024 Jan;65(1). Figure: F5.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates IFITM3 IFITM3 ncbigene_symbol IFITM3 10410
Homo sapiens Primates TRAF6 TRAF6 ncbigene_symbol TRAF6 7189
Homo sapiens Primates IRAK1 IRAK1 ncbigene_symbol IRAK1 3654
Homo sapiens Primates MAPK MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates (p-ERK) PERK ncbigene_synonym EIF2AK3 9451
Homo sapiens Primates c-Myc: CMYC ncbigene_synonym MYC 4609
Homo sapiens Primates AP-1 AP-1 ncbigene_synonym FOS 2353
Homo sapiens Primates AP-1 AP-1 ncbigene_synonym FOSB 2354
Homo sapiens Primates AP-1 AP-1 ncbigene_synonym JUN 3725
Homo sapiens Primates AP-1 AP-1 ncbigene_synonym JUNB 3726
Homo sapiens Primates AP-1 AP-1 ncbigene_synonym JUND 3727

Chemical mentions

Word Match MeSH Name ChEBI
Nucleus nucleus nucleus chebi:33252

Disease mentions

Word Match MeSH Name DOID