MAPK signaling pathway containing T

(A) MAPK signaling pathway containing T. forsythia upregulated miRNAs in mandibles compared with sham-infected controls at p ≤ 0.05, adapted from the pathway express and using KEGG. Red boxes indicate 45 upregulated miRNA profiles from the NanoString analysis. Green boxes indicate no change in gene expression. An arrow indicates a molecular interaction resulting in classical MAP kinase pathway, phosphatidylinositol signaling system, JNK and p 38 MAP kinase pathway, p53 signaling pathway, ERK5 pathway, Wnt signaling pathway. A line without an arrowhead indicates a molecular interaction resulting in inhibition. Solid and dash-dotted lines denote direct and indirect relationships, respectively. +P indicates phosphorylation, and −P indicates dephosphorylation. The MAPK cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. (B) T cell receptor signaling pathway containing T. forsythia downregulated miRNAs in mandibles compared with sham-infected controls at p ≤ 0.05, adapted from the pathway express and using KEGG. Red boxes indicate 31 significantly downregulated miRNA profiles from the NanoString analysis. Green boxes indicate no change in gene expression. An arrow indicates a molecular interaction resulting in MAPK signaling pathway, calcium signaling pathway, PI3K-Akt signaling pathway, NF-κB signaling pathway, and ubiquitin-mediated proteolysis. A line without an arrowhead indicates a molecular interaction resulting in inhibition

Publication

Unique miRomics Expression Profiles in Tannerella forsythia-Infected Mandibles during Periodontitis Using Machine Learning (2023) Chairmandurai Aravindraja, et al. Int J Mol Sci. 2023 Nov;24(22). Figure: F3. Homo sapiens

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