Wnt Signaling pathway

Wnt Signaling pathway. The diagram provides an overview of the major components and interactions within the Wnt signaling pathway such as LEF1 and TCF/LEF1 complex. The color assignments in IPA are based on statistical analyses, such as the z-score. The z-score compares the observed gene expression changes in a given dataset to a reference dataset, assessing the significance and direction of those changes. Positive z-scores indicate upregulation = red, orange = activated, whereas negative z-scores indicate downregulation = green, blue = inhibited, and z-scores close to zero indicate no significant change = no color, and purple indicates interactions of two or more factors. The color scheme employed in this figure is consistent with the color scheme utilized in all presented figures
Wnt Signaling pathway
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Publication

Effects of S-Adenosylhomocysteine Hydrolase Downregulation on Wnt Signaling Pathway in SW480 Cells (2023) Ivana Pavičić, et al. Int J Mol Sci. 2023 Nov;24(22). Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates WNT/B-cateninSignaling:sw480scrwtoverlap:ExprLogRatio WNT famplex_relations WNT1 7471
Homo sapiens Primates WNT/B-cateninSignaling:sw480scrwtoverlap:ExprLogRatio WNT famplex_relations WNT2 7472
Homo sapiens Primates WNT/B-cateninSignaling:sw480scrwtoverlap:ExprLogRatio WNT famplex_relations WNT2B 7482
Homo sapiens Primates WNT/B-cateninSignaling:sw480scrwtoverlap:ExprLogRatio WNT famplex_relations WNT3 7473
Homo sapiens Primates WNT/B-cateninSignaling:sw480scrwtoverlap:ExprLogRatio WNT famplex_relations WNT3A 89780
Homo sapiens Primates WNT/B-cateninSignaling:sw480scrwtoverlap:ExprLogRatio WNT famplex_relations WNT4 54361
Homo sapiens Primates WNT/B-cateninSignaling:sw480scrwtoverlap:ExprLogRatio WNT famplex_relations WNT6 7475
Homo sapiens Primates WNT/B-cateninSignaling:sw480scrwtoverlap:ExprLogRatio WNT famplex_relations WNT7A 7476
Homo sapiens Primates WNT/B-cateninSignaling:sw480scrwtoverlap:ExprLogRatio WNT famplex_relations WNT7B 7477
Homo sapiens Primates WNT/B-cateninSignaling:sw480scrwtoverlap:ExprLogRatio WNT famplex_relations WNT8A 7478
Homo sapiens Primates WNT/B-cateninSignaling:sw480scrwtoverlap:ExprLogRatio WNT famplex_relations WNT8B 7479
Homo sapiens Primates WNT/B-cateninSignaling:sw480scrwtoverlap:ExprLogRatio WNT famplex_relations WNT9A 7483
Homo sapiens Primates WNT/B-cateninSignaling:sw480scrwtoverlap:ExprLogRatio WNT famplex_relations WNT9B 7484
Homo sapiens Primates WNT/B-cateninSignaling:sw480scrwtoverlap:ExprLogRatio WNT famplex_relations WNT10A 80326
Homo sapiens Primates WNT/B-cateninSignaling:sw480scrwtoverlap:ExprLogRatio WNT famplex_relations WNT10B 7480
Homo sapiens Primates WNT/B-cateninSignaling:sw480scrwtoverlap:ExprLogRatio WNT famplex_relations WNT11 7481
Homo sapiens Primates WNT/B-cateninSignaling:sw480scrwtoverlap:ExprLogRatio WNT famplex_relations WNT16 51384
Homo sapiens Primates WNT/B-cateninSignaling:sw480scrwtoverlap:ExprLogRatio WNT famplex_relations WNT5A 7474
Homo sapiens Primates WNT/B-cateninSignaling:sw480scrwtoverlap:ExprLogRatio WNT famplex_relations WNT5B 81029
Homo sapiens Primates B-catenin CTNNB1 ncbigene_symbol CTNNB1 1499
Homo sapiens Primates SRO SRO ncbigene_synonym STOML3 161003
Homo sapiens Primates PINT PINT ncbigene_synonym LINC-PINT 378805
Homo sapiens Primates APC/APC2CTNNB14-GSK3- APC ncbigene_symbol APC 324
Homo sapiens Primates APC/APC2CTNNB14-GSK3- APC ncbigene_synonym PROC 5624
Homo sapiens Primates APC2 APC2 ncbigene_symbol APC2 10297
Homo sapiens Primates APC2 APC2 ncbigene_synonym ANAPC2 29882
Homo sapiens Primates APC2 APC2 ncbigene_synonym SLC25A23 79085
Homo sapiens Primates AXIN1 AXIN1 ncbigene_symbol AXIN1 8312
Homo sapiens Primates PP2A PP2A ncbigene_synonym PTPA 5524
Homo sapiens Primates WIF1 WIF1 ncbigene_symbol WIF1 11197
Homo sapiens Primates TGFBR TGFBR famplex_relations TGFBR1 7046
Homo sapiens Primates TGFBR TGFBR famplex_relations TGFBR2 7048
Homo sapiens Primates TGFBR TGFBR famplex_relations TGFBR3 7049
Homo sapiens Primates KREMEN KREMEN ncbigene_synonym KREMEN1 83999
Homo sapiens Primates MARK2 MARK2 ncbigene_symbol MARK2 2011
Homo sapiens Primates MAP4K1 MAP4K1 ncbigene_symbol MAP4K1 11184
Homo sapiens Primates TAB1 TAB1 ncbigene_symbol TAB1 10454
Homo sapiens Primates MAP3K7 MAP3K7 ncbigene_symbol MAP3K7 6885
Homo sapiens Primates BTRC BTRC ncbigene_symbol BTRC 8945
Homo sapiens Primates MDM2 MDM2 ncbigene_symbol MDM2 4193
Homo sapiens Primates CDKN2A CDKN2A ncbigene_symbol CDKN2A 1029
Homo sapiens Primates TP53) TP53 ncbigene_symbol TP53 7157
Homo sapiens Primates RAR RAR ncbigene_synonym RARA 5914
Homo sapiens Primates RAR RAR ncbigene_synonym RAB40B 10966
Homo sapiens Primates RAR RAR famplex_relations RARB 5915
Homo sapiens Primates RAR RAR famplex_relations RARG 5916
Homo sapiens Primates RUVBL2 RUVBL2 ncbigene_symbol RUVBL2 10856
Homo sapiens Primates APPL APPL ncbigene_synonym APPL1 26060
Homo sapiens Primates HDAC) HDAC ncbigene_synonym HDAC9 9734
Homo sapiens Primates HDAC) HDAC famplex_relations HDAC1 3065
Homo sapiens Primates HDAC) HDAC famplex_relations HDAC2 3066
Homo sapiens Primates HDAC) HDAC famplex_relations HDAC3 8841
Homo sapiens Primates HDAC) HDAC famplex_relations HDAC8 55869
Homo sapiens Primates HDAC) HDAC famplex_relations HDAC4 9759
Homo sapiens Primates HDAC) HDAC famplex_relations HDAC5 10014
Homo sapiens Primates HDAC) HDAC famplex_relations HDAC7 51564
Homo sapiens Primates HDAC) HDAC famplex_relations HDAC6 10013
Homo sapiens Primates HDAC) HDAC famplex_relations HDAC10 83933
Homo sapiens Primates HDAC) HDAC famplex_relations SIRT1 23411
Homo sapiens Primates HDAC) HDAC famplex_relations SIRT2 22933
Homo sapiens Primates HDAC) HDAC famplex_relations SIRT3 23410
Homo sapiens Primates HDAC) HDAC famplex_relations SIRT4 23409
Homo sapiens Primates HDAC) HDAC famplex_relations SIRT5 23408
Homo sapiens Primates HDAC) HDAC famplex_relations SIRT6 51548
Homo sapiens Primates HDAC) HDAC famplex_relations SIRT7 51547
Homo sapiens Primates HDAC) HDAC famplex_relations HDAC11 79885
Homo sapiens Primates p300 P300 ncbigene_synonym EP300 2033
Homo sapiens Primates NLK NLK ncbigene_symbol NLK 51701
Homo sapiens Primates NLK NLK ncbigene_synonym GPI 2821
Homo sapiens Primates TCF TCF ncbigene_synonym HNF4A 3172
Homo sapiens Primates NR5A2 NR5A2 ncbigene_symbol NR5A2 2494
Homo sapiens Primates MMP MMP famplex_relations MMP1 4312
Homo sapiens Primates MMP MMP famplex_relations MMP2 4313
Homo sapiens Primates MMP MMP famplex_relations MMP3 4314
Homo sapiens Primates MMP MMP famplex_relations MMP7 4316
Homo sapiens Primates MMP MMP famplex_relations MMP8 4317
Homo sapiens Primates MMP MMP famplex_relations MMP9 4318
Homo sapiens Primates MMP MMP famplex_relations MMP10 4319
Homo sapiens Primates MMP MMP famplex_relations MMP11 4320
Homo sapiens Primates MMP MMP famplex_relations MMP12 4321
Homo sapiens Primates MMP MMP famplex_relations MMP13 4322
Homo sapiens Primates MMP MMP famplex_relations MMP14 4323
Homo sapiens Primates MMP MMP famplex_relations MMP15 4324
Homo sapiens Primates MMP MMP famplex_relations MMP16 4325
Homo sapiens Primates MMP MMP famplex_relations MMP17 4326
Homo sapiens Primates MMP MMP famplex_relations MMP19 4327
Homo sapiens Primates MMP MMP famplex_relations MMP20 9313
Homo sapiens Primates MMP MMP famplex_relations MMP21 118856
Homo sapiens Primates MMP MMP famplex_relations MMP23B 8510
Homo sapiens Primates MMP MMP famplex_relations MMP24 10893
Homo sapiens Primates MMP MMP famplex_relations MMP25 64386
Homo sapiens Primates MMP MMP famplex_relations MMP26 56547
Homo sapiens Primates MMP MMP famplex_relations MMP27 64066
Homo sapiens Primates MMP MMP famplex_relations MMP28 79148
Homo sapiens Primates JUN JUN ncbigene_symbol JUN 3725
Homo sapiens Primates JUN JUN famplex_relations JUNB 3726
Homo sapiens Primates JUN JUN famplex_relations JUND 3727
Homo sapiens Primates CCND1 CCND1 ncbigene_symbol CCND1 595
Homo sapiens Primates TCF4 TCF4 ncbigene_symbol TCF4 6925
Homo sapiens Primates TCF4 TCF4 ncbigene_synonym TCF7L2 6934
Homo sapiens Primates HNF1A HNF1A ncbigene_symbol HNF1A 6927
Homo sapiens Primates MYC MYC ncbigene_symbol MYC 4609
Homo sapiens Primates PPARD PPARD ncbigene_symbol PPARD 5467
Homo sapiens Primates DKK1 DKK1 ncbigene_symbol DKK1 22943
Homo sapiens Primates SFRP1 SFRP1 ncbigene_symbol SFRP1 6422
Homo sapiens Primates All ALL ncbigene_synonym BCR 613
Homo sapiens Primates All AII ncbigene_synonym NLRP3 114548
Homo sapiens Primates AXIN2 AXIN2 ncbigene_symbol AXIN2 8313
Homo sapiens Primates CD44 CD44 ncbigene_symbol CD44 960

Chemical mentions

Word Match MeSH Name ChEBI
Nucleus nucleus nucleus chebi:33252
beta beta e(-) chebi:10545

Disease mentions

Word Match MeSH Name DOID