Toll-like receptor (TLR) signaling pathways

Schematic representation of Toll-like receptor (TLR) signaling pathways. All TLRs except for TLR3 are thought to share the MyD88-dependent pathway that activates NF-κB and mitogen-activated protein (MAP) kinases, leading to the induction of inflammatory cytokine genes. Interleukin-1 receptor-associated kinases (IRAKs) and TRAF6 are located downstream of MyD88. TIRAP is involved in the MyD88-dependent pathway downstream of TLR2 and TLR4. TRIF is utilized in the TLR3-mediated and TLR4-mediated activation of interferon regulatory factor (IRF)3 and the subsequent induction of IRF3-dependent gene expression such as interferon-β (IFN-β). TRAM is specifically involved in the activation of IRF3 in TLR4 signaling. The complex of TBK1/IκB kinase-i (IKK-i) is responsible for the activation of IRF3 downstream of TRIF in TLR3 and TLR4 signaling. TRAF6 is also involved in the TRIF-dependent activation of NF-κB and MAP kinases. Receptor-interacting protein (RIP) mediates TRIF-dependent NF-κB activation. DD, death domain.
Toll-like receptor (TLR) signaling pathways

Publication

Toll-like receptor downstream signaling. (2005) Taro Kawai, et al. Arthritis Res Ther. 2005;7(1):12-19. Figure: F3.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents TLR4 TLR4 ncbigene_symbol Tlr4 21898
Mus musculus Rodents TLR7 TLR7 ncbigene_symbol Tlr7 170743
Mus musculus Rodents TLR9 TLR9 ncbigene_symbol Tlr9 81897
Mus musculus Rodents TLR3 TLR3 ncbigene_symbol Tlr3 142980
Mus musculus Rodents TLR5 TLR5 ncbigene_symbol Tlr5 53791
Mus musculus Rodents TLR1 TLR1 ncbigene_symbol Tlr1 21897
Mus musculus Rodents TLR1/2 TLR2 ncbigene_symbol Tlr2 24088
Mus musculus Rodents TIRAP TIRAP ncbigene_symbol Tirap 117149
Mus musculus Rodents TRAM TRAM ncbigene_synonym Tmed7 66676
Mus musculus Rodents TRAM TRAM ncbigene_synonym Ticam2 225471
Mus musculus Rodents TAK1 TAK1 ncbigene_synonym Nr2c2 22026
Mus musculus Rodents TAK1 TAK1 ncbigene_synonym Map3k7 26409
Mus musculus Rodents TRIF TRIF ncbigene_synonym Rnf138 56515
Mus musculus Rodents TRIF TRIF ncbigene_synonym Trim69 70928
Mus musculus Rodents TRIF TRIF ncbigene_synonym Ticam1 106759
Mus musculus Rodents MyD88 MYD88 ncbigene_symbol Myd88 17874
Mus musculus Rodents TRAF6 TRAF6 ncbigene_symbol Traf6 22034
Mus musculus Rodents RIP RIP ncbigene_symbol Rip 110628
Mus musculus Rodents RIP RIP ncbigene_synonym Agfg1 15463
Mus musculus Rodents RIP RIP ncbigene_synonym Ptpn13 19249
Mus musculus Rodents RIP RIP ncbigene_synonym Ripk1 19766
Mus musculus Rodents RIP RIP ncbigene_synonym Rpain 69723
Mus musculus Rodents IRF3 IRF3 ncbigene_symbol Irf3 54131
Mus musculus Rodents NF-KB NF-KB ncbigene_synonym Nfkb1 18033
Mus musculus Rodents IFNB IFNB ncbigene_synonym Ifnb1 15977
Homo sapiens Primates TLR4 TLR4 ncbigene_symbol TLR4 7099
Homo sapiens Primates TLR7 TLR7 ncbigene_symbol TLR7 51284
Homo sapiens Primates TLR9 TLR9 ncbigene_symbol TLR9 54106
Homo sapiens Primates TLR3 TLR3 ncbigene_symbol TLR3 7098
Homo sapiens Primates TLR5 TLR5 ncbigene_symbol TLR5 7100
Homo sapiens Primates TLR1 TLR1 ncbigene_symbol TLR1 7096
Homo sapiens Primates TLR1/2 TLR2 ncbigene_symbol TLR2 7097
Homo sapiens Primates TIRAP TIRAP ncbigene_symbol TIRAP 114609
Homo sapiens Primates TRAM TRAM ncbigene_synonym TRAM1 23471
Homo sapiens Primates TRAM TRAM ncbigene_synonym TICAM2 353376
Homo sapiens Primates TRAM TRAM ncbigene_synonym TMED7-TICAM2 100302736
Homo sapiens Primates TAK1 TAK1 ncbigene_synonym MAP3K7 6885
Homo sapiens Primates TAK1 TAK1 ncbigene_synonym NR2C2 7182
Homo sapiens Primates TRIF TRIF ncbigene_synonym TRIM69 140691
Homo sapiens Primates TRIF TRIF ncbigene_synonym TICAM1 148022
Homo sapiens Primates MyD88 MYD88 ncbigene_symbol MYD88 4615
Homo sapiens Primates TRAF6 TRAF6 ncbigene_symbol TRAF6 7189
Homo sapiens Primates RIP RIP ncbigene_synonym AGFG1 3267
Homo sapiens Primates RIP RIP ncbigene_synonym RIPK1 8737
Homo sapiens Primates RIP RIP ncbigene_synonym DCAF1 9730
Homo sapiens Primates RIP RIP ncbigene_synonym RPAIN 84268
Homo sapiens Primates IRF3 IRF3 ncbigene_symbol IRF3 3661
Homo sapiens Primates NF-KB NF-KB ncbigene_synonym NFKB1 4790
Homo sapiens Primates IFNB IFNB ncbigene_synonym IFNB1 3456
Homo sapiens Primates IFNo/s IFN ncbigene_synonym IFNA1 3439
Homo sapiens Primates MAP MAP ncbigene_synonym SGSM3 27352
Drosophila melanogaster Invertebrates TLR4 TLR4 ncbigene_synonym Toll-4 34235
Drosophila melanogaster Invertebrates TLR1 TLR1 ncbigene_synonym tok 42944
Drosophila melanogaster Invertebrates TLR1/2 TLR2 ncbigene_symbol tlr-2 44349
Drosophila melanogaster Invertebrates TRAM TRAM ncbigene_symbol TRAM 31042
Drosophila melanogaster Invertebrates TAK1 TAK1 ncbigene_symbol Tak1 39659
Drosophila melanogaster Invertebrates MyD88 MYD88 ncbigene_symbol Myd88 35956
Drosophila melanogaster Invertebrates TRAF6 TRAF6 ncbigene_symbol Traf6 31746
Drosophila melanogaster Invertebrates RIP RIP ncbigene_symbol rip 44045
Drosophila melanogaster Invertebrates RIP RIP ncbigene_synonym ripp 246815
Drosophila melanogaster Invertebrates NF-KB NF-KB ncbigene_synonym Dif 35045
Drosophila melanogaster Invertebrates NF-KB NF-KB ncbigene_synonym dl 35047
Drosophila melanogaster Invertebrates NF-KB NF-KB ncbigene_synonym Rel 41087
Drosophila melanogaster Invertebrates MAP MAP ncbigene_synonym mapP 45332
Drosophila melanogaster Invertebrates DD DD ncbigene_symbol Dd 33107
Danio rerio Vertebrates TLR7 TLR7 ncbigene_symbol tlr7 100534776
Danio rerio Vertebrates TLR9 TLR9 ncbigene_symbol tlr9 403128
Danio rerio Vertebrates TLR3 TLR3 ncbigene_symbol tlr3 403126
Danio rerio Vertebrates TLR5 TLR5 ncbigene_synonym tlr5b 403139
Danio rerio Vertebrates TLR1 TLR1 ncbigene_symbol tlr1 403127
Danio rerio Vertebrates TLR1/2 TLR2 ncbigene_symbol tlr2 403125
Danio rerio Vertebrates TIRAP TIRAP ncbigene_symbol tirap 403148
Danio rerio Vertebrates TRAM TRAM ncbigene_synonym tram1 266757
Danio rerio Vertebrates TRIF TRIF ncbigene_synonym ticam1 403147
Danio rerio Vertebrates MyD88 MYD88 ncbigene_symbol myd88 403145
Danio rerio Vertebrates TRAF6 TRAF6 ncbigene_symbol traf6 554561
Danio rerio Vertebrates IRF3 IRF3 ncbigene_symbol irf3 564854
Danio rerio Vertebrates IFNo/s IFN ncbigene_synonym ifnphi1 360134
Danio rerio Vertebrates kinases KINASE ncbigene_synonym pak2a 266749
Danio rerio Vertebrates kinases KINASE ncbigene_synonym itpka 368717

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID