Toll-like receptor (TLR) signaling pathways
Schematic representation of Toll-like receptor (TLR) signaling pathways. All TLRs except for TLR3 are thought to share the MyD88-dependent pathway that activates NF-κB and mitogen-activated protein (MAP) kinases, leading to the induction of inflammatory cytokine genes. Interleukin-1 receptor-associated kinases (IRAKs) and TRAF6 are located downstream of MyD88. TIRAP is involved in the MyD88-dependent pathway downstream of TLR2 and TLR4. TRIF is utilized in the TLR3-mediated and TLR4-mediated activation of interferon regulatory factor (IRF)3 and the subsequent induction of IRF3-dependent gene expression such as interferon-β (IFN-β). TRAM is specifically involved in the activation of IRF3 in TLR4 signaling. The complex of TBK1/IκB kinase-i (IKK-i) is responsible for the activation of IRF3 downstream of TRIF in TLR3 and TLR4 signaling. TRAF6 is also involved in the TRIF-dependent activation of NF-κB and MAP kinases. Receptor-interacting protein (RIP) mediates TRIF-dependent NF-κB activation. DD, death domain.

Publication
Toll-like receptor downstream signaling. (2005) Taro Kawai, et al. Arthritis Res Ther. 2005;7(1):12-19. Figure: F3.Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
---|---|---|---|---|---|---|
Mus musculus | Rodents | TLR4 | TLR4 | ncbigene_symbol | Tlr4 | 21898 |
Mus musculus | Rodents | TLR7 | TLR7 | ncbigene_symbol | Tlr7 | 170743 |
Mus musculus | Rodents | TLR9 | TLR9 | ncbigene_symbol | Tlr9 | 81897 |
Mus musculus | Rodents | TLR3 | TLR3 | ncbigene_symbol | Tlr3 | 142980 |
Mus musculus | Rodents | TLR5 | TLR5 | ncbigene_symbol | Tlr5 | 53791 |
Mus musculus | Rodents | TLR1 | TLR1 | ncbigene_symbol | Tlr1 | 21897 |
Mus musculus | Rodents | TLR1/2 | TLR2 | ncbigene_symbol | Tlr2 | 24088 |
Mus musculus | Rodents | TIRAP | TIRAP | ncbigene_symbol | Tirap | 117149 |
Mus musculus | Rodents | TRAM | TRAM | ncbigene_synonym | Tmed7 | 66676 |
Mus musculus | Rodents | TRAM | TRAM | ncbigene_synonym | Ticam2 | 225471 |
Mus musculus | Rodents | TAK1 | TAK1 | ncbigene_synonym | Nr2c2 | 22026 |
Mus musculus | Rodents | TAK1 | TAK1 | ncbigene_synonym | Map3k7 | 26409 |
Mus musculus | Rodents | TRIF | TRIF | ncbigene_synonym | Rnf138 | 56515 |
Mus musculus | Rodents | TRIF | TRIF | ncbigene_synonym | Trim69 | 70928 |
Mus musculus | Rodents | TRIF | TRIF | ncbigene_synonym | Ticam1 | 106759 |
Mus musculus | Rodents | MyD88 | MYD88 | ncbigene_symbol | Myd88 | 17874 |
Mus musculus | Rodents | TRAF6 | TRAF6 | ncbigene_symbol | Traf6 | 22034 |
Mus musculus | Rodents | RIP | RIP | ncbigene_symbol | Rip | 110628 |
Mus musculus | Rodents | RIP | RIP | ncbigene_synonym | Agfg1 | 15463 |
Mus musculus | Rodents | RIP | RIP | ncbigene_synonym | Ptpn13 | 19249 |
Mus musculus | Rodents | RIP | RIP | ncbigene_synonym | Ripk1 | 19766 |
Mus musculus | Rodents | RIP | RIP | ncbigene_synonym | Rpain | 69723 |
Mus musculus | Rodents | IRF3 | IRF3 | ncbigene_symbol | Irf3 | 54131 |
Mus musculus | Rodents | NF-KB | NF-KB | ncbigene_synonym | Nfkb1 | 18033 |
Mus musculus | Rodents | IFNB | IFNB | ncbigene_synonym | Ifnb1 | 15977 |
Homo sapiens | Primates | TLR4 | TLR4 | ncbigene_symbol | TLR4 | 7099 |
Homo sapiens | Primates | TLR7 | TLR7 | ncbigene_symbol | TLR7 | 51284 |
Homo sapiens | Primates | TLR9 | TLR9 | ncbigene_symbol | TLR9 | 54106 |
Homo sapiens | Primates | TLR3 | TLR3 | ncbigene_symbol | TLR3 | 7098 |
Homo sapiens | Primates | TLR5 | TLR5 | ncbigene_symbol | TLR5 | 7100 |
Homo sapiens | Primates | TLR1 | TLR1 | ncbigene_symbol | TLR1 | 7096 |
Homo sapiens | Primates | TLR1/2 | TLR2 | ncbigene_symbol | TLR2 | 7097 |
Homo sapiens | Primates | TIRAP | TIRAP | ncbigene_symbol | TIRAP | 114609 |
Homo sapiens | Primates | TRAM | TRAM | ncbigene_synonym | TRAM1 | 23471 |
Homo sapiens | Primates | TRAM | TRAM | ncbigene_synonym | TICAM2 | 353376 |
Homo sapiens | Primates | TRAM | TRAM | ncbigene_synonym | TMED7-TICAM2 | 100302736 |
Homo sapiens | Primates | TAK1 | TAK1 | ncbigene_synonym | MAP3K7 | 6885 |
Homo sapiens | Primates | TAK1 | TAK1 | ncbigene_synonym | NR2C2 | 7182 |
Homo sapiens | Primates | TRIF | TRIF | ncbigene_synonym | TRIM69 | 140691 |
Homo sapiens | Primates | TRIF | TRIF | ncbigene_synonym | TICAM1 | 148022 |
Homo sapiens | Primates | MyD88 | MYD88 | ncbigene_symbol | MYD88 | 4615 |
Homo sapiens | Primates | TRAF6 | TRAF6 | ncbigene_symbol | TRAF6 | 7189 |
Homo sapiens | Primates | RIP | RIP | ncbigene_synonym | AGFG1 | 3267 |
Homo sapiens | Primates | RIP | RIP | ncbigene_synonym | RIPK1 | 8737 |
Homo sapiens | Primates | RIP | RIP | ncbigene_synonym | DCAF1 | 9730 |
Homo sapiens | Primates | RIP | RIP | ncbigene_synonym | RPAIN | 84268 |
Homo sapiens | Primates | IRF3 | IRF3 | ncbigene_symbol | IRF3 | 3661 |
Homo sapiens | Primates | NF-KB | NF-KB | ncbigene_synonym | NFKB1 | 4790 |
Homo sapiens | Primates | IFNB | IFNB | ncbigene_synonym | IFNB1 | 3456 |
Homo sapiens | Primates | IFNo/s | IFN | ncbigene_synonym | IFNA1 | 3439 |
Homo sapiens | Primates | MAP | MAP | ncbigene_synonym | SGSM3 | 27352 |
Drosophila melanogaster | Invertebrates | TLR4 | TLR4 | ncbigene_synonym | Toll-4 | 34235 |
Drosophila melanogaster | Invertebrates | TLR1 | TLR1 | ncbigene_synonym | tok | 42944 |
Drosophila melanogaster | Invertebrates | TLR1/2 | TLR2 | ncbigene_symbol | tlr-2 | 44349 |
Drosophila melanogaster | Invertebrates | TRAM | TRAM | ncbigene_symbol | TRAM | 31042 |
Drosophila melanogaster | Invertebrates | TAK1 | TAK1 | ncbigene_symbol | Tak1 | 39659 |
Drosophila melanogaster | Invertebrates | MyD88 | MYD88 | ncbigene_symbol | Myd88 | 35956 |
Drosophila melanogaster | Invertebrates | TRAF6 | TRAF6 | ncbigene_symbol | Traf6 | 31746 |
Drosophila melanogaster | Invertebrates | RIP | RIP | ncbigene_symbol | rip | 44045 |
Drosophila melanogaster | Invertebrates | RIP | RIP | ncbigene_synonym | ripp | 246815 |
Drosophila melanogaster | Invertebrates | NF-KB | NF-KB | ncbigene_synonym | Dif | 35045 |
Drosophila melanogaster | Invertebrates | NF-KB | NF-KB | ncbigene_synonym | dl | 35047 |
Drosophila melanogaster | Invertebrates | NF-KB | NF-KB | ncbigene_synonym | Rel | 41087 |
Drosophila melanogaster | Invertebrates | MAP | MAP | ncbigene_synonym | mapP | 45332 |
Drosophila melanogaster | Invertebrates | DD | DD | ncbigene_symbol | Dd | 33107 |
Danio rerio | Vertebrates | TLR7 | TLR7 | ncbigene_symbol | tlr7 | 100534776 |
Danio rerio | Vertebrates | TLR9 | TLR9 | ncbigene_symbol | tlr9 | 403128 |
Danio rerio | Vertebrates | TLR3 | TLR3 | ncbigene_symbol | tlr3 | 403126 |
Danio rerio | Vertebrates | TLR5 | TLR5 | ncbigene_synonym | tlr5b | 403139 |
Danio rerio | Vertebrates | TLR1 | TLR1 | ncbigene_symbol | tlr1 | 403127 |
Danio rerio | Vertebrates | TLR1/2 | TLR2 | ncbigene_symbol | tlr2 | 403125 |
Danio rerio | Vertebrates | TIRAP | TIRAP | ncbigene_symbol | tirap | 403148 |
Danio rerio | Vertebrates | TRAM | TRAM | ncbigene_synonym | tram1 | 266757 |
Danio rerio | Vertebrates | TRIF | TRIF | ncbigene_synonym | ticam1 | 403147 |
Danio rerio | Vertebrates | MyD88 | MYD88 | ncbigene_symbol | myd88 | 403145 |
Danio rerio | Vertebrates | TRAF6 | TRAF6 | ncbigene_symbol | traf6 | 554561 |
Danio rerio | Vertebrates | IRF3 | IRF3 | ncbigene_symbol | irf3 | 564854 |
Danio rerio | Vertebrates | IFNo/s | IFN | ncbigene_synonym | ifnphi1 | 360134 |
Danio rerio | Vertebrates | kinases | KINASE | ncbigene_synonym | pak2a | 266749 |
Danio rerio | Vertebrates | kinases | KINASE | ncbigene_synonym | itpka | 368717 |
Word | Match | MeSH | Name | ChEBI |
---|
Disease mentions
Word | Match | MeSH | Name | DOID |
---|