Signaling pathways associated with ERA

Signaling pathways associated with ERα. ERα is mainly involved in the E2/ERα signaling pathway, which includes classical and non-classical approaches. In addition, ERα regulates the PI3K/AKT/mTOR, MAPK, WNT/β-catenin and JAK/STAT signaling pathways. ERα, estrogen receptor α; E2, estrogen/estradiol.
Signaling pathways associated with ERA
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Publication

Roles of estrogen receptor α in endometrial carcinoma (Review) (2023) Yidong Ge, et al. Oncol Lett. 2023 Dec;26(6). Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates mTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates PI3K/AKT/mTOR AKT ncbigene_synonym AKT1 207
Homo sapiens Primates PI3K/AKT/mTOR AKT famplex_relations AKT2 208
Homo sapiens Primates PI3K/AKT/mTOR AKT famplex_relations AKT3 10000
Homo sapiens Primates MAPK MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates ERa ERA ncbigene_synonym ESR1 2099
Homo sapiens Primates ERa ERA ncbigene_synonym ERAL1 26284
Homo sapiens Primates Rheb RHEB ncbigene_symbol RHEB 6009
Homo sapiens Primates Rheb RHEB ncbigene_synonym RHEBP1 6008
Homo sapiens Primates PDK1 PDK1 ncbigene_symbol PDK1 5163
Homo sapiens Primates PDK1 PDK1 ncbigene_synonym PDPK1 5170
Homo sapiens Primates GRB2 GRB2 ncbigene_symbol GRB2 2885
Homo sapiens Primates SOS SOS ncbigene_synonym XYLT2 64132
Homo sapiens Primates SOS SOS famplex_relations SOS1 6654
Homo sapiens Primates SOS SOS famplex_relations SOS2 6655
Homo sapiens Primates Ras RAS famplex_relations KRAS 3845
Homo sapiens Primates Ras RAS famplex_relations HRAS 3265
Homo sapiens Primates Ras RAS famplex_relations NRAS 4893
Homo sapiens Primates (GTP) GTP ncbigene_synonym MTG1 92170
Homo sapiens Primates LRP LRP ncbigene_synonym RPSA 3921
Homo sapiens Primates LRP LRP ncbigene_synonym LRP1 4035
Homo sapiens Primates LRP LRP ncbigene_synonym PTPRA 5786
Homo sapiens Primates LRP LRP ncbigene_synonym MVP 9961
Homo sapiens Primates WNT WNT famplex_relations WNT1 7471
Homo sapiens Primates WNT WNT famplex_relations WNT2 7472
Homo sapiens Primates WNT WNT famplex_relations WNT2B 7482
Homo sapiens Primates WNT WNT famplex_relations WNT3 7473
Homo sapiens Primates WNT WNT famplex_relations WNT3A 89780
Homo sapiens Primates WNT WNT famplex_relations WNT4 54361
Homo sapiens Primates WNT WNT famplex_relations WNT6 7475
Homo sapiens Primates WNT WNT famplex_relations WNT7A 7476
Homo sapiens Primates WNT WNT famplex_relations WNT7B 7477
Homo sapiens Primates WNT WNT famplex_relations WNT8A 7478
Homo sapiens Primates WNT WNT famplex_relations WNT8B 7479
Homo sapiens Primates WNT WNT famplex_relations WNT9A 7483
Homo sapiens Primates WNT WNT famplex_relations WNT9B 7484
Homo sapiens Primates WNT WNT famplex_relations WNT10A 80326
Homo sapiens Primates WNT WNT famplex_relations WNT10B 7480
Homo sapiens Primates WNT WNT famplex_relations WNT11 7481
Homo sapiens Primates WNT WNT famplex_relations WNT16 51384
Homo sapiens Primates WNT WNT famplex_relations WNT5A 7474
Homo sapiens Primates WNT WNT famplex_relations WNT5B 81029
Homo sapiens Primates Frizzled FZD famplex_relations FZD1 8321
Homo sapiens Primates Frizzled FZD famplex_relations FZD10 11211
Homo sapiens Primates Frizzled FZD famplex_relations FZD2 2535
Homo sapiens Primates Frizzled FZD famplex_relations FZD3 7976
Homo sapiens Primates Frizzled FZD famplex_relations FZD4 8322
Homo sapiens Primates Frizzled FZD famplex_relations FZD5 7855
Homo sapiens Primates Frizzled FZD famplex_relations FZD6 8323
Homo sapiens Primates Frizzled FZD famplex_relations FZD7 8324
Homo sapiens Primates Frizzled FZD famplex_relations FZD8 8325
Homo sapiens Primates Frizzled FZD famplex_relations FZD9 8326
Homo sapiens Primates STAT STAT ncbigene_synonym SOAT1 6646
Homo sapiens Primates STAT STAT famplex_relations STAT1 6772
Homo sapiens Primates STAT STAT famplex_relations STAT2 6773
Homo sapiens Primates STAT STAT famplex_relations STAT3 6774
Homo sapiens Primates STAT STAT famplex_relations STAT4 6775
Homo sapiens Primates STAT STAT famplex_relations STAT6 6778
Homo sapiens Primates STAT STAT famplex_relations STAT5A 6776
Homo sapiens Primates STAT STAT famplex_relations STAT5B 6777
Homo sapiens Primates JAK JAK famplex_relations JAK1 3716
Homo sapiens Primates JAK JAK famplex_relations JAK2 3717
Homo sapiens Primates JAK JAK famplex_relations JAK3 3718
Homo sapiens Primates JAK JAK famplex_relations TYK2 7297
Homo sapiens Primates CKla CKIA ncbigene_synonym CSNK1A1 1452
Homo sapiens Primates (GSK-3ẞ) GSK3 famplex_relations GSK3A 2931
Homo sapiens Primates (GSK-3ẞ) GSK3 famplex_relations GSK3B 2932
Homo sapiens Primates Raf RAF ncbigene_synonym ZHX2 22882
Homo sapiens Primates Raf RAF famplex_relations ARAF 369
Homo sapiens Primates Raf RAF famplex_relations BRAF 673
Homo sapiens Primates Raf RAF famplex_relations RAF1 5894
Homo sapiens Primates Axin AXIN ncbigene_synonym AXIN1 8312
Homo sapiens Primates Axin AXIN famplex_relations AXIN2 8313
Homo sapiens Primates APC APC ncbigene_symbol APC 324
Homo sapiens Primates APC APC ncbigene_synonym PROC 5624
Homo sapiens Primates B-catenin CTNNB1 ncbigene_symbol CTNNB1 1499
Homo sapiens Primates TSC1/2 TSC1 ncbigene_symbol TSC1 7248
Homo sapiens Primates TSC1/2 TSC1 ncbigene_synonym CCL26 10344
Homo sapiens Primates TSC1/2 TSC2 ncbigene_symbol TSC2 7249
Homo sapiens Primates MEK MEK ncbigene_synonym MAP2K7 5609
Homo sapiens Primates MEK MEK famplex_relations MAP2K1 5604
Homo sapiens Primates MEK MEK famplex_relations MAP2K2 5605
Homo sapiens Primates EFEMP1 EFEMP1 ncbigene_symbol EFEMP1 2202
Homo sapiens Primates ERK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates mTORC1 MTORC1 famplex_relations RPTOR 57521
Homo sapiens Primates 4E-BP1 4E-BP1 ncbigene_synonym EIF4EBP1 1978
Homo sapiens Primates P70S6K P70S6K ncbigene_synonym RPS6KB1 6198
Homo sapiens Primates P70S6K P70S6K famplex_relations RPS6KB2 6199
Homo sapiens Primates TF TF ncbigene_symbol TF 7018
Homo sapiens Primates TCF/LEF TCF ncbigene_synonym HNF4A 3172

Chemical mentions

Word Match MeSH Name ChEBI
ERa ERA chebi:51451
Ras RAS (1R)-N-(prop-2-yn-1-yl)indan-1-amine chebi:63620
Ras RAS (1R)-N-(prop-2-yn-1-yl)indan-1-amine chebi:63620
ERa ERA chebi:51451
ERa ERA chebi:51451
MEK MEK butan-2-one chebi:28398
ERa ERA chebi:51451
ERa ERA chebi:51451
ERa ERA chebi:51451
COA CoA 3'-phosphonatoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl] diphosphate} chebi:57287
ERa ERA chebi:51451

Disease mentions

Word Match MeSH Name DOID